Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jeffrey Cohen · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $213,441 — Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), is associated with respiratory-related disease and death. Assays to detect virus-specific antibodies are important to understand the prevalence of infection and the course of the immune re…
Joshua Tan · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $2,338,839 — The overarching goal of this project is to study the immune response to pathogens at the monoclonal level to increase our understanding of basic biology and develop new tools to combat disease. We are currently focusing our efforts on human monoclonal antibodies against three pathogens, Plasmodium f…
Patrick Duffy · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $13,666 — In July 2020, we commenced a community COVID-19 seroprevalence study at existing clinical trials sites in Mali. This study is a Public Health Surveillance Activity in collaboration with the Ministry of Health in Mali to describe the sero-epidemiology of COVID-19 in urban and rural populations. Using…
Jason Brenchley · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $251,276 — Severe SARSCov2 disease occurs, predominantly, in humans with one of several preexisting conditions including cardiovascular disease, advanced age, obesity, and diabetes. These underlying conditions tend to have inflammation in common. Indeed, dexamethasone treatment is showing utility in COVID19. W…
Tracy L Nolen · RESEARCH TRIANGLE INSTITUTE · 2024 · $289,604,000 — RTI International is pleased to provide this application as requested by the Research Opportunities Announcement OTA-20-011 ACTIV Integration of Host-targeting Therapies for COVID-19 for the role of Administrative Coordinating Center (ACC). The title of our application is ACTIV Integration of Host-t…
Dunli Wu · ASIAN COMMUNITY HEALTH COALITION · 2024 · $374,999 — 1.- Modified Project Summary/Abstract Section Community-Led Health Impact Project (CLIP) Over 38 million Americans live with type 2 diabetes and more than 122 million have hypertension. Asian Americans face elevated risks for both conditions despite relatively low obesity rates. Our community need…
Suzanne Spisso · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $19,666,918 — ICMOB supports the intramural research program through a variety of activities that are aimed towards facilitation of clinical research, enhanced patient care and safety, and the professional development of intramural staff. To accomplish this ICMOB provides clinical support through a variety of mec…
Blake Warner · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · 2024 · $1,642,409 — Natural history and pathogenesis of Sjogren's syndrome(SS) The primary objective of this study is to enable the collection of longitudinal clinical and laboratory data and biologic specimens to identify pathogenetic mechanisms of SS and other salivary gland dysfunction clinical states by careful cl…
Joshua Denny · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · 2024 · $1,427,000 — 1. Blood pressure (BP) and hypertension (HTN) in large-scale biobanks HTN is a major risk factor for cardiovascular disease, the leading cause of death worldwide. We conducted GWAS for blood pressure traits in over one million individuals, identifying 2103 associated loci, and leveraged our results …
Eric Nawrocki · NATIONAL LIBRARY OF MEDICINE · 2024 · $250,010 — We improved our software package VADR (https://github.com/nawrockie/vadr) for viral sequence analysis over the past year. VADR validates and annotates viral genomes and other sequences based on comparison and alignment to reference models based on RefSeq sequences. It is currently used in an automa…
Swee Lay Thein · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $234,770 — Sickle Cell Disease (SCD) is caused by a single amino acid substitution of valine by glutamic acid at the 6th position of the β-globin gene which results in the production of hemoglobin S (HbS). Under low oxygen conditions, HbS polymerizes and results in sickling of red blood cells (RBCs) triggering…
SANKAR ADHYA · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,025,659 — Using our phage-based vaccine technology, we have succeeded (i) in eliciting highly specific vaccines against EGRvIII glioblastoma cancer cells in Mouse. This phage vaccine would next be tested by injecting into live model mouse. with EGFRvIII glioblastoma for efficacy. (ii) Constructed (in collabor…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,021,081 — An ideal HIV vaccine should provide protection against all HIV-1 variants. Thus, an important aspect of HIV vaccine development is the selection of immunogens, which has to be taken into consideration, the diversity of the different HIV clades and the identification of the critical epitopes able to …
Robert Yarchoan · DIVISION OF BASIC SCIENCES - NCI · 2024 · $201,039 — The SARS2 Mpro is functional as a dimer; however, its ability to form a dimer is affected by various conditions, such as its state of oxidation and its concentration, Moreover, SARS-CoV-2 Mpro contains 12 cysteines, a large number for a protein of this size. We have observed that the protease has a …
YVES POMMIER · DIVISION OF BASIC SCIENCES - NCI · 2024 · $1,196,333 — We are testing chemical candidate compounds in our TOP3B cellular and biochemical assays. We have engineered cloned cell lines with reporters ("green-GFP" and "red-mCherry") allowing concurrent cultures of TOP3B wild-type (TOP3B+/+) and knockout (TOP3B-KO = TOP3B-/-) cells and used them for high thr…
Deborah Merke · CLINICAL CENTER · 2024 — Our recruitment of patients continues to be excellent and represents the largest cohort of CAH and FMPP patients ever seen at one center. To date, we have enrolled over 500 patients with CAH, and 19 patients with FMPP. This Natural History study allows for longitudinal characterization and timely r…
Amy Pate Patterson · CLINICAL CENTER · 2024 — Regarding our research in lipid metabolism, we have demonstrated that SR-BI mediates LDL binding as well as cholesterol ester (CE) and triacylglycerol (TAG) sorting followed by their internalization to LDs. While about 60% of LDL- delivered neutral lipid (NL) to be uploaded to LDs requires neutral h…
Adriaan Bax · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $658,712 — The soft palate and back of the throat represent vulnerable early infection sites for SARS-CoV-2, influenza, streptococci, and many other pathogens. We demonstrated in a laboratory experiment that voluntary generation of snoring sounds causes aerosolization of pharyngeal fluid that covers these surf…
William Marston Linehan · DIVISION OF BASIC SCIENCES - NCI · 2024 · $3,679,130 — Investigators in the Urologic Oncology Branch of the National Cancer Institute are the urologic surgeons and general urology consultants to the entire National Institutes of Health. In this role we see patients in consultation for all pediatric and adult urologic surgical problems. The Urologic Onco…
Stephen Whitehead · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $16,391 — A detailed statement of work was prepared to describe the activities to be carried out by the AFRIMS group in Bangkok, Thailand. An Interagency Agreement (A-AI-12-051-0000-0000) was executed between NIAID and the U.S. Army Medical Research and Materiel Command and became effective on 09-01-2012. Thi…