Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Dylan J Taatjes · UNIVERSITY OF COLORADO · 2024 · $633,029 — SUMMARY/ABSTRACT Our research program combines detailed biochemical reconstitution experiments with powerful cell-based assays, with a goal of gaining fundamental mechanistic insights about RNA polymerase II (pol II) function and its regulation. The 12-subunit human pol II enzyme transcribes all pro…
Shruti Naik · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $537,321 — PROJECT SUMMARY The skin serves as a primary barrier to the external world and is thus often injured. As such, rapid repair of tissue damage is vital for organismal survival. Failure to repair wounds results in the formation of chronic or non-healing wounds, which affect over 2% of the western popu…
Marina Kukla · RLR VA MEDICAL CENTER · 2024 — Project background: Work is a major social determinant of health. In people with serious mental illness (SMI), work is associated with better wellbeing, physical and mental health, quality of life, and may prevent the onset of disability. Among Veterans with SMI, work is a protective factor against …
Dorey Glenn · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $197,260 — ABSTRACT Influenza and pneumococcal infections occurring in individuals with glomerular disease are preventable contributors to excess healthcare utilization, morbidity, and mortality, and occur at a rate approximately 30 times higher among individuals with glomerular diseases compared to the genera…
ANDREA I MCCLATCHEY · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $353,684 — Project Summary The intrahepatic biliary tree functions to drain bile from hepatocytic canaliculi away from the liver. Congenital or acquired abnormalities in the formation and patency of intrahepatic bile ducts have severe, often fatal consequences. In the developing liver, biliary morphogenesis is…
Michael D. Burkart · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $434,671 — Project Summary. In complex ecosystems, microbes use secondary metabolism as a means to communicate within and control their local environment. Some of these products have had profound utility for the treatment of human diseases, particularly infectious disease, where a large percentage of currently…
Kim M Cecil · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $1,074,630 — PROJECT SUMMARY / ABSTRACT More than one in five adolescents will experience a mental health disorder, including depression and anxiety, and the prevalence of these conditions is increasing. Among adolescents, depression and anxiety are linked to increased risk of suicide, a leading cause of death i…
Tara Ann Niendam · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $1,578,817 — Project Summary A prolonged first episode of psychosis (FEP) without adequate treatment is the most consistent predictor of poor clinical and functional outcomes 1, poor health outcomes 2 and significant economic burden 3. Team-based “coordinated specialty care” (CSC)4 for early psychosis (EP) has e…
ALEXANDER W CHARNEY · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $831,329 — Project Summary In this new and unfunded study, we will capitalize on the lessons from the past 15 years of psychiatric genomic. Based on these lessons, we propose an exceptionally novel and important set of aims to further knowledge of the genetic architecture of mental illness. We propose to perfo…
Michael Esterman · VA BOSTON HEALTH CARE SYSTEM · 2024 — The suicide rate among active duty service members and veterans increased substantially following the onset of post-9/11 conflicts in Iraq and Afghanistan1. Accordingly, veteran suicide prevention has been identified as a national healthcare and research priority2. Psychosocial interventions for sui…
Brent L Berwin · JACKSON LABORATORY · 2024 · $213,164 — PROJECT SUMMARY/ABSTRACT The goal of the annual Jackson Laboratory Short Course on Experimental Models of Human Cancer is to train graduate students, postdocs, and junior investigators in the basic science and application of experimental models of human cancer. The training program will immerse part…
Irina G. Luzina · BALTIMORE VA MEDICAL CENTER · 2024 — Interleukin (IL)-33 and its receptor, ST2, centrally control a remarkable variety of inflammatory and fibrotic diseases. The IL-33 – ST2 axis relies mostly on the proteolytically mature form of IL-33 cytokine (MIL33), with less attention usually devoted to the full-length precursor (FLIL33), which i…
Hari Eswaran · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $380,000 — Abstract Currently, we can record non-invasive fetal magnetocardiographic (FMCG) signals with a magnetic sensor- based system called SARA (SQUID Array for Reproductive Assessment) installed at University of Arkansas for Medical Sciences. The study of the fetal heart, and in particular, the developin…
Maciej Walczak · UNIVERSITY OF COLORADO · 2024 · $302,384 — PROJECT SUMMARY/ABSTRACT Antibiotics have transformed the human health and disease landscape. However, the use and misuse of such antimicrobial drugs accelerate the emergence of bacterial strains resistant against antibiotics, so that standard treatment options eventually become ineffective. In ligh…
Alex Francis Manini · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $648,054 — The purpose of this R01 proposal is to deepen our knowledge of the primary cause of drug overdose deaths in the U.S. today: novel psychoactive synthetic opioids, the majority of which are fentanyl analogues. Using a nationwide registry of patients who present to emergency departments, novel fentanyl…
Colin Goding · UNIVERSITY OF PENNSYLVANIA · 2024 · $393,894 — SUMMARY Despite the emergence novel therapeutic modalities, including BRAF inhibitors and immunotherapies, over 7,100 people are expected to die each year from malignant melanoma, primarily from metastatic dissemination and therapy resistance. The proposed studies leverage the expertise of the two c…
JUN LUO · JOHNS HOPKINS UNIVERSITY · 2024 · $355,850 — PROJECT SUMMARY Homologous recombination (HR) deficiency (HRD), particularly from biallelic mutational loss of BRCA1/BRCA2/ATM (BRCA/ATM), is significantly enriched in men with metastatic castration-resistant prostate cancer (mCRPC). Such patients have multiple FDA-approved systemic life-prolonging …
Jussuf Thomas Kaifi · HARRY S. TRUMAN MEMORIAL VA HOSPITAL · 2024 — Non-small cell lung cancer (NSCLC) is by far the leading cancer killer in Veterans. Major reasons for death after surgical resection are the >50% recurrence rate despite curative intent treatment due to micrometastatic disease at the time of diagnosis. To prevent the development of metastatic recurr…
Christopher Court Lapish · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $482,653 — Project Summary/Abstract The INIAstress consortium will employ a diverse set of scientific approaches to understand the brain mechanisms that underlie stress and alcohol interactions. There is a commitment among the consortium to deliberately carry out the science in a way that provides synergy acro…
Daniel Philip Giovenco · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $564,965 — PROJECT SUMMARY/ABSTRACT Tobacco retailer density is disproportionately high in low-income communities and certain racial/ethnic enclaves, contributing to severe socioeconomic and social disparities in smoking and its resultant health harms. Local, environmental-level interventions that aim to reduc…