Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Manoj T Duraisingh · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $239,250 — Malaria is a life-threatening disease that is transmitted to humans by the bite of Anopheline mosquitoes infected with Plasmodium parasites. Proliferation of parasites within erythrocytes in the bloodstream is central to the parasite’s survival and results in the pathogenesis of malaria. Little is k…
Johnathan R. Whetstine · RESEARCH INST OF FOX CHASE CAN CTR · 2024 · $467,500 — PROJECT SUMMARY DNA amplification is associated with pathological states such as neurological disorders, cardiac disease and cancer. At least 50% of the amplifications in cancer are transient extrachromosomal DNA (ecDNA). The transient behavior contributes to copy number plasticity, results in heter…
Matthew J Styles · UNIVERSITY OF CHICAGO · 2024 · $74,284 — Project Summary Alterations in protein-protein interactions (PPI) can result in dysregulated biological signaling. PPIs are critical drivers of a plethora of disease states and are increasingly recognized as important therapeutic targets. However, PPIs have been difficult to target with traditional …
Melanie Boly · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $163,080 — Scientific abstract Epilepsy is a chronic and debilitating disease, leading to refractory seizures in up to 40% of patients. A better understanding of the neural mechanisms that cause recurrent seizures could lead to improved diagnostic markers and new neuroprotective therapies. My recent research …
Darrell N. Kotton · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $638,086 — Project Summary/Abstract Idiopathic pulmonary fibrosis (IPF) remains a deadly interstitial lung disease (ILD) with treatment options limited by an incomplete understanding of the mechanisms that initiate and perpetuate disease. A growing literature now implicates lung epithelial dysfunction as playi…
Susan E Ramsey · RHODE ISLAND HOSPITAL · 2024 · $677,305 — There are more than a million persons living with HIV in the United States. Despite the effectiveness of antiretroviral therapy (ART), viral suppression, particularly durable viral suppression, can be difficult to achieve. Suboptimal ART adherence plays a significant role in unsuccessful viral suppr…
Margarita L Zuley · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $452,223 — Abstract A primary concern regarding current breast cancer detection and diagnosis is the large number of benign biopsies being performed. Annually in the United States, radiologists recall over five million women for diagnostic workup and perform over one million breast biopsies, with fewer than on…
Jennifer Nicole Walker · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $137,938 — PPROJECT ABSTRACT More than 30 million urinary catheters (UCs) are placed every year in the US, making them the most commonly used indwelling medical device. While short-term UC usage is common in hospitals as part of standard patient care, chronic indwelling UCs are frequently used outside the heal…
Kayla Herbell · OHIO STATE UNIVERSITY · 2024 · $275,625 — Project Summary Although adolescents (ages 11 to 17) make treatment gains (e.g., reduced internalizing or externalizing behaviors) in psychiatric residential treatment (RT), they experience significant difficulty adapting to the community and often do not sustain treatment gains long term. After RT,…
Edmund Au · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $200,442 — PROJECT SUMMARY: Fragile X Syndrome (FXS) is a common genetic form of intellectual disability that is frequently co-morbid with autism-like clinical features. It is caused by epigenetic silencing of the FMR1 gene, which encodes for the protein FMRP, an RNA binding protein with a strong preference fo…
Yizhi Sun · DANA-FARBER CANCER INST · 2024 · $127,781 — Abstract Thermogenic adipocytes and adaptive thermogenesis are promising therapeutic targets for treating and preventing obesity and obesity-linked diabetes. We recently demonstrated that the mitochondrial tissue- nonspecific alkaline phosphatase, TNAP, plays a crucial role in the futile creatine c…
John Timberlake · BERKSHIRE BIOMEDICAL CORPORATION · 2024 · $221,860 — ABSTRACT Methadone maintenance reduces and/or eliminates the use of opioids, reduces the death rates and criminality associated with opioid use, and allows patients to improve their health and social productivity. In addition, enrollment in Methadone Maintenance Treatment (MMT) can reduce the transm…
Brittany Butts · EMORY UNIVERSITY · 2024 · $192,780 — ABSTRACT The purpose of this study is to determine the extent to which vascular risk factors are associated with biomarkers of Alzheimer’s disease (AD) risk over time in middle aged adults with heart failure with preserved ejection fraction (HFpEF). Mid-life cardiovascular risk factors contribute to…
Thomas J Carew · NEW YORK UNIVERSITY · 2024 · $476,413 — PROJECT SUMMARY/ABSTRACT A growing body of evidence suggests that growth factors (GFs), once considered to function mainly in development, also regulate synaptic plasticity and memory in the adult. This proposal reflects on an ongoing research program in our laboratory that has focused on the role o…
Robi D Mitra · WASHINGTON UNIVERSITY · 2024 · $248,535 — Abstract: This proposal seeks the renewal of the Opportunities in Genomics Research (OGR) Program. Since 2007, the OGR Program has been run out of The McDonnell Genome Institute at Washington University in Saint Louis and funded through the NHGRI's Diversity Action Plan. The mission of the OGR Progr…
Gary S. Aston-Jones · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $533,775 — Project Summary/Abstract A large number of studies over the last 14 years show that orexin neurons play an important role in reward processing and drug abuse. Although these studies show that orexin-1 receptor (OxR1) signaling is particularly involved in the motivation for many drugs of abuse, none …
Stephanie W Watts · MICHIGAN STATE UNIVERSITY · 2024 · $2,639,839 — Summary - Overall Vascular health is essential to the normal regulation of cardiovascular function. That dysfunctions of blood pressure regulation, such as hypertension, remain difficult to treat suggests that the scientific community does not fully understand the mechanisms by which normal and pat…
Hanping Feng · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $621,331 — Abstract Human norovirus (hNoV) and Clostridium difficile (CD) represent two leading causes of acute gastroenteritis worldwide with significant morbidity and mortality. The two infections (one viral and one bacterial) share many of the same characteristics of transmission; and concurrent infections …
Dawn Marie Bravata · RALPH H JOHNSON VA MEDICAL CENTER · 2024 — Background: Despite the proven efficacy and safety of statins, nearly 250,000 Veterans at high-risk for cardiovascular disease (CVD) seen annually in primary care are not taking them leading to higher cholesterol levels, cardiovascular risk, and health care costs. Primary care providers and health s…
Gail Kurr Adler · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $760,464 — ABSTRACT Hypertension is a major risk factor for cardiovascular (CV) morbidity and mortality. Increased CV risk remains even if blood pressure (BP) is controlled, suggesting there are additional factors associated with hypertension (influenced by, but independent of, BP per se), which contribute to …