Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
SEEMA BHATNAGAR · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $220,000 — SUMMARY Habituation is the progressive decline in responses to repeated exposure to the same, homotypic stressor. It is highly conserved and observed in species ranging from humans to rodents. Habituation is adaptive because it allows animals to filter out irrelevant stimuli and focus selectively on…
DAVID B. WEINER · WISTAR INSTITUTE · 2024 · $4,420,687 — Overall Summary A protective vaccine for HIV is arguably the most important prevention strategy to end the global HIV pandemic. The RV144 trial demonstrated a correlation between protection and envelope (Env) specific serum IgG antibodies. However, there was a notable lack of HIV-specific neutralizi…
MARK T NELSON · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $887,845 — PROJECT SUMMARY Neurons in the brain have limited energy reserves and thus rely on a “just-in-time” delivery strategy in which active neurons signal to the brain microvasculature to increase regional cerebral blood flow (CBF), resupplying nutrients and oxygen as well as removing toxic metabolites. D…
Suzanne AW Fuqua · BAYLOR COLLEGE OF MEDICINE · 2024 · $324,901 — Our research focus is estrogen receptor (ER)-positive luminal breast cancer, representing 75% of primary breast cancer patients, who are prescribed adjuvant endocrine therapy (ET) with hormonal agents. While recurrences are delayed by the use of ET, resistance can evolve with the development of meta…
Howard C Hang · SCRIPPS RESEARCH INSTITUTE, THE · 2024 · $527,560 — PROJECT SUMMARY Microbiota are associated with remarkable effects on host health and disease. Notably, discrete species of commensal bacteria have been correlated with improved patient responses to cancer immunotherapy. However, the molecular mechanisms underlying the functions of these beneficial b…
Adolfo Garcia-Sastre · JACKSON LABORATORY · 2024 · $2,465,186 — PROJECT SUMMARY The WHO estimates that annual epidemics of influenza result in 3-5 million cases of severe illness and 300,000- 500,000 deaths. 90% of influenza-related deaths occur in older adults despite widespread vaccination programs with vaccines tailored for this high-risk group. The estimated…
Caitlin Walfoort Elgarten · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $185,652 — PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award proposal will provide didactic and experiential training, expert mentorship, and an exceptional research environment to facilitate Dr. Caitlin Elgarten's development as an independent clinician scientist. Dr. E…
Luke Joseph Peppone · UNIVERSITY OF ROCHESTER · 2024 · $607,140 — ABSTRACT: Use of androgen deprivation therapy (ADT), which causes near-total loss of testosterone, has increased dramatically in elderly prostate cancer patients over the last decade. ADT is associated with a significant increase in bone mineral density (BMD) loss (2-5% annually) and bone fractures,…
Aki Ushiki · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $114,015 — PROJECT SUMMARY Mutations in gene regulatory elements (REs) are a major cause of human disease. For example, the majority (>90%) of disease related genome wide association studies (GWAS) found associations with variants in non- coding and likely regulatory regions in the genome. Despite their import…
Douglas A. Bayliss · UNIVERSITY OF VIRGINIA · 2024 · $474,809 — A discrete group of neurons located in the retrotrapezoid nucleus (RTN) that express the transcription factor, Phox2b provide a crucial excitatory drive to regulate downstream respiratory rhythm/pattern-generating circuits. The activity of these neurons is modulated by changes in CO2 (or its proxy, …
Lin Han · DREXEL UNIVERSITY · 2024 · $326,990 — PROJECT SUMMARY The development of novel cartilage regeneration and osteoarthritis (OA) treatments is limited by our incomplete understanding of how certain molecular activities in cartilage extracellular matrix (ECM) are linked to its matrix assembly and biomechanical functions. This project will …
Vijay Rathinam · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2024 · $410,000 — Inflammasome related caspases such as caspase-1, caspase-4, and caspase-11 are a subset of the caspase family specialized in executing a lytic form of cell death and IL-1 cytokine-based inflammatory response. The activation of these inflammatory caspases is strongly coupled to innate immune detectio…
Emily Frances Boss · JOHNS HOPKINS UNIVERSITY · 2024 · $157,500 — PROJECT SUMMARY Racial/ethnic minority children who undergo surgery have worse clinical outcomes compared to white or more affluent peers. Although clinical and environmental determinants contribute to these disparities, evidence suggests that these disparities may rise in part from racial/ethnic di…
Brian T. Cunningham · STANFORD UNIVERSITY · 2024 · $712,782 — Abstract Frequent, accurate, and highly sensitive HIV-1 viral load monitoring is a critical component of AIDS antiretroviral therapy, a tool for reducing the incidence of mother-to-child HIV transmission, and a required element of routine diagnostic testing to make people aware of their HIV status. …
Christopher Graziul · UNIVERSITY OF CHICAGO · 2024 · $551,709 — PROJECT SUMMARY While researchers continue to study the effects of disproportionate minority contact with law enforcement on a range of health-related outcomes, a recent review of this work questions the methodological validity of most studies on this topic. Many of these concerns focus on (a) unrea…
Elisabeth Bernhardt · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $12,655 — PROJECT SUMMARY Both high incidence (i.e., 15%) and low remission rate (i.e., 30-50%) of postpartum distress symptoms indicate a need for more research on the underlying mechanisms associated with elevated maternal distress and caregiving deficits. Severe symptoms of maternal distress will continue …
Chris Glembotski · UNIVERSITY OF ARIZONA · 2024 · $602,693 — PROJECT SUMMARY Increases in protein synthesis during pathological cardiac hypertrophy places demands on protein-folding machinery to avert the accumulation of toxic misfolded proteins. Associated with the endoplasmic reticulum (ER), where many important proteins are synthesized in cardiac myocytes,…
LAURA S PORTER · DUKE UNIVERSITY · 2024 · $478,506 — For patients and their intimate partners, advanced cancer poses significant physical and emotional challenges that can negatively impact both the individuals and the couple. Couples’ ability to communicate openly and effectively with each other about cancer-related concerns can improve their psychol…
Lucas Matthew Donovan · VA PUGET SOUND HEALTHCARE SYSTEM · 2024 — Background: The VA is tasked with providing specialty care services for ~4 million Veterans annually, and specialty care for obstructive sleep apnea (OSA) provides representative challenges and opportunities to improve access to high-quality care. Almost 50% of Veterans are at high risk for OSA, and…
Abraam M. Yakoub · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $765,148 — Project Summary Neurodegenerative diseases, especially Alzheimer’s Disease (AD) and Parkinson’s Disease (PD), affect millions of people globally and represent a US major healthcare burden. AD is the world’s most common cause of dementia, and is the sixth leading cause of death in the US. PD is motor…