Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Marta Rodriguez Garcia · WAYNE STATE UNIVERSITY · 2024 · $514,523 — PROJECT SUMMARY Urogenital infections, including sexually transmitted infections and other genitourinary tract infections, are a major source of morbidity and mortality in older women, yet how aging impacts mucosal immune protection in the female genital tract (FGT) remains largely unknown. Thus, to…
LAUREN BERGER SHOMAKER · COLORADO STATE UNIVERSITY · 2024 · $102,081 — Project Summary Lauren Shomaker, Ph.D., is a licensed clinical psychologist and clinical researcher with a strong track record of NIH grantsmanship, scholarship, and commitment to mentoring in patient-oriented research (POR) at the intersection of mental health and cardiometabolic health. Dr. Shomak…
Hyo Sik Jang · VAN ANDEL RESEARCH INSTITUTE · 2024 · $153,160 — PROJECT SUMMARY One hallmark of cancer is a tumor’s ability to evade immune detection and elimination. Immune checkpoint inhibitors (ICIs) are an attractive therapeutic strategy for many cancers. After many clinical trials targeting various solid cancer types, however, only 15-40% of patients benefi…
Henry M. Colecraft · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $517,445 — SUMMARY Mutations in CaV2.1 pore-forming 1A subunit cause a spectrum of neurological diseases including epileptic encephalopathies (EE), familial hemiplegic migraine type 1 (FHM1), episodic ataxia type 2 (EA2), spinocerebellar ataxia type 6 (SCA6), and intellectual disability (ID). The ClinVar data…
Tatiana Segura · DUKE UNIVERSITY · 2024 · $485,635 — Summary Stroke is the leading cause of adult disability in the US. There are no therapeutic options beyond physical therapy to reduce disability burden; thus, new therapeutic options are highly needed. The stroke cavity is the region of the brain that dies after stroke and does not spontaneously reg…
LISA A BRIAND · TEMPLE UNIV OF THE COMMONWEALTH · 2024 · $109,528 — PROJECT SUMMARY When entering college, similar numbers of underrepresented minority (URM) students plan to major in STEM fields as non-Hispanic white students. However, pipeline leakage reduces the number of URM students entering STEM careers following graduation. One way to address this pipeline le…
Tammy English · WASHINGTON UNIVERSITY · 2024 · $577,053 — PROJECT SUMMARY In the progression from middle to older-age, healthy adults typically experience improvements in their emotional functioning, such as increases in positive emotion and greater expertise in managing emotions. However, not everyone shows these age-related improvements, and the mechanis…
Edward A Fisher · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $819,950 — ABSTRACT Coronary plaques begin their progression in childhood, making their reversal an important clinical goal in adulthood. The understanding of mechanisms underlying atherosclerosis regression has been understudied compared to plaque progression. Atherosclerosis represents a failure to resolve t…
Michelle Zhang · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $30,161 — Project Summary Normal vision depends on the balanced generation and homeostatic regulation of major retinal cell types, and the disruption of these processes may result in congenital retinal disorders and retinal degeneration, affecting millions of people around the world each year. Regenerative me…
Linda Valeri · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $532,149 — SUMMARY To develop multi-faceted interventions for Alzheimer’s Disease and Related Disorders (ADRD) prevention, it is key to quantify joint effects of environmental exposures throughout the life-span as well as the mechanisms through which the exposures operate, which involve dynamic disease proces…
Alberto Cruz-Martin · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $412,500 — PROJECT SUMMARY Cortical subregions are often implicated in a variety of behavioral functions, but it is not well understood how these areas encode such diverse information. The anterior cingulate cortex (ACC) is necessary for emotional processing and social cognition, but how it encodes stimuli rel…
Allison Lindauer · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $592,668 — PROJECT SUMMARY The purpose of this NIH Stage 1B mixed methods study is to test the feasibility, acceptability, fidelity and efficacy of a telehealth-based intervention designed to reduce stress for family care partners (CP) for those with Alzheimer's disease and related dementias (ADRD). ADRD extra…
Sandipan Chowdhury · UNIVERSITY OF IOWA · 2024 · $337,351 — Mechanisms of voltage regulation of membrane transport SLC9 family of membrane transporters couple the import of sodium ions to export of protons. They are vital for regulation of cytoplasmic and endosomal pH, which in turn affect several physiological processes. Their disfunction has been linked to…
Daniel B Vigneron · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,211,237 — PROJECT SUMMARY/ABSTRACT The overall goal of this Hyperpolarized MRI Technology Resource Center (HMTRC) renewal project is to develop and disseminate optimal new hyperpolarized (HP) 13C MR technologies with requisite training/documentation to advance significantly this emerging molecular imaging met…
Pratibha Singh · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $396,250 — ABSTRACT Hematopoietic stem cell (HSC) transplantation is a therapeutic cure for hematological malignancies, metabolic disorders, and inherited and acquired bone marrow (BM) failure. However, myeloablative conditioning regimens routinely used for transplantation cause acute and long-term BM damage, …
Ziv Williams · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $531,720 — Studying semantic processing during language comprehension in humans at the single-cellular level Humans are capable of communicating extraordinarily rich and nuanced meanings through language. This capacity surpasses that of all other animal species. Yet, despite a growing understanding of the netw…
Ingo Helbig · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $694,724 — PROJECT SUMMARY Over the last decade, there has been an exponential increase in identified genetic causes of neurodevelopmental disorders and epilepsy. With more than 100 genes identified, understanding how phenotypes relate to specific genetic variants is critical, given the clinical complexity of …
Benjamin M Sivyer · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $437,571 — Project Summary The retina conveys visual information to the brain through retinal ganglion cells whose axons make up the optic nerve. There are many different types of retinal ganglion cells that in parallel convey a different component of vision, such as detail, color, direction, or intensity. Mos…
PHILLIP A YATES · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $199,812 — Project Summary Leishmania parasites cause a suite of devastating Neglected Tropical Diseases that afflict as many as one million people per year. At least 20,000 are killed each year by the deadly visceral form of the disease, which is caused by L. donovani. Genetic tools for understanding importa…
Ingo Helbig · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $697,071 — PROJECT SUMMARY Over the last decade, there has been an exponential increase in identified genetic causes of neurodevelopmental disorders and epilepsy. With more than 100 genes identified, understanding how phenotypes relate to specific genetic variants is critical given the clinical complexity of d…