Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Martha W Bagnall · WASHINGTON UNIVERSITY · 2024 · $377,088 — Project Summary As animals locomote, they constantly coordinate activity between the rostral and caudal ends of the body. This coordination relies on neurons in the spinal cord that send long ascending or descending axonal projections. Although several studies have shown that ablation of these neuro…
Dongwen Lyu · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $192,844 — PROJECT SUMMARY Caspases are a family of cysteine proteases which can cleave proteins containing cleavage sites on the flexible region to trigger cell death through apoptosis or pyroptosis. Recently, bifunctional small molecules, such as proteolysis targeting chimeras (PROTACs), lysosome targeting c…
John J. Erickson · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $193,212 — PROJECT SUMMARY TITLE: Maternal B cells enforce fetal tolerance GOALS/OBJECTIVES: The overall goal of this five-year proposal for a Mentored Clinical Scientist Research Career Development Award (K08) is for me to develop into a productive, independent academic investigator in the field of reproducti…
Michael Fang · JOHNS HOPKINS UNIVERSITY · 2024 · $156,496 — Michael Fang, PHD, MHS is an Assistant Professor in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health. He seeks a K01 Mentored Research Scientist Development Award in order to obtain essential skills and mentored research experience for an independent career as a scie…
Rebeccah Warmack · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2024 · $123,446 — PROJECT SUMMARY. Nitrogen fixation by the metalloenzyme nitrogenase supports nearly 50% of the global population and is the only biological pathway for nitrogen reduction. Nitrogenase consists of two proteins, the obligate reductase Fe-protein and the catalytic MoFe-protein, both of which are rapidl…
Emily Choquette · LAUREATE INSTITUTE FOR BRAIN RESEARCH · 2024 · $158,035 — PROJECT ABSTRACT/SUMMARY Dr. Emily Choquette is applying for the Mentored Patient-Oriented Career Development Award (K23) to support her growth as an independent researcher focusing on understanding the pathophysiology of body image disturbance (BID). BID is a key diagnostic feature of AN that is as…
Yu-Chieh David Chen · NEW YORK UNIVERSITY · 2024 · $154,332 — Project Summary Diverse neuronal types are specified into correct cell fates and connected with proper targets during circuit formation. Over the last decades, a number of cell surface molecules have also been identified that mediate axon guidance and connectivity. However, little is known about the…
Alexander James Kula · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2024 · $191,143 — Project Summary: Dr. Alex Kula, MD, MHS, is an Assistant Professor in the Department of Pediatrics at Northwestern University Feinberg School of Medicine (NU) and attending physician in the Division of Pediatric Nephrology at the Ann and Robert H. Lurie Children’s Hospital of Chicago (LCH). The K23 …
Allegra Adele Petti · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $249,832 — A major impediment to the treatment of glioblastoma (GBM) is its extensive intratumoral heterogeneity: Each GBM tumor is heterogeneous with respect to genetics, immune microenvironment, and tumor cell state. In particular, single-cell RNA-sequencing (scRNA-seq) has revealed that each GBM is a mixtur…
Rakesh K. Srivastava · GLAX, LLC · 2024 · $55,000 — Abstract Pancreatic cancer is a slow-growing disease with a 5-year survival rate of approximately 9%. It is the fourth leading cause of cancer-related deaths in the US. Currently used pancreatic cancer drugs are not very effective and exhibit severe side effects. Patients develop drug resistance and…
William Nathaniel Brennen · JOHNS HOPKINS UNIVERSITY · 2024 · $394,398 — Though initially responsive to hormonal therapy, prostate cancer (PCa) invariably progresses to an incurable metastatic castration-resistant state (mCRPC). Additionally, the proportion of patients with androgen receptor (AR)-indifferent mCRPCe has increased significantly in the post-supracastration …
Chandan Guha · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $458,589 — Abstract Pancreatic cancer is the leading cause of cancer-related death with less than 5% (5-year) survival rate with current treatment regimen involving chemo-radiation therapy. Almost all patients with pancreatic cancer eventually develop metastatic disease with poor prognosis for survival. There …
Amy Strom · PRINCETON UNIVERSITY · 2024 · $120,534 — Project Summary Despite advances in sequencing, imaging and screening technologies, morphological changes in nuclear structure are still utilized as a common and reliable diagnosis of cancer. Healthy cells invariably have ellipsoid, smooth nuclear shape and distinctive chromatin distribution, while…
ASMA NUSRAT · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $482,628 — Abstract The gastrointestinal epithelium plays a central role in maintaining barrier function while coordinating mucosal homeostasis and immunity. An important negative consequence of excessive inflammation, ischemia, certain infections, and other clinical conditions is mucosal epithelial injury and…
Morgan Rose Wilt Timm · WASHINGTON UNIVERSITY · 2024 · $34,926 — PROJECT SUMMARY / ABSTRACT Antimicrobial resistance (AMR) contributes to an estimated 5 million deaths worldwide each year and is directly responsible for over 1.2 million deaths. In the not-to-distant future, we may face a reality where infections resistant to all existing antibiotics are commonpla…
Jana Ariel Hirsch · DREXEL UNIVERSITY · 2024 · $693,256 — PROJECT SUMMARY/ABSTRACT Beyond the role that individual factors (e.g. age, race, gender, and socioeconomic status) play in the progression of Alzheimer's Disease and related dementias (ADRD), neighborhood factors (e.g. social and built environments) may affect cognitive health. Critically, although…
ROBERT T TRANQUILLO · UNIVERSITY OF MINNESOTA · 2024 · $361,549 — Project Summary This research plan is aimed at creating an off-the-shelf transcatheter vein valve capable of regeneration. If successful, it could treat many thousands of patients who suffer from chronic venous insufficiency in deep veins, untreatable with compression stockings, and the sequelae of…
JANG H. YOUN · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $400,325 — Epoxyeicosatrienoic acids (EETs) are lipid mediators with beneficial effects on metabolic and cardiovascular (CV) health. EETs and other FFA epoxides are quickly metabolized to biologically less active diols by soluble epoxide hydrolase (sEH). Inhibition of sEH, which increases EETs, improves metabo…
Anna Bukiya · UNIVERSITY OF SOUTH FLORIDA · 2024 · $435,815 — In the United States, fetal alcohol spectrum disorders (FASD) represent the leading preventable cause of birth defects and neurodevelopmental delay with life-long implications. FASD affects an estimated 40,000 infants in the US each year, with 2-5% of younger school-age children having FASD. Current…
Christopher Lee Baker · JACKSON LABORATORY · 2024 · $20,000 — PROJECT SUMMARY Research and experimental use of pluripotent stem cells has expanded rapidly, and these cells now provide important research models of human disease and personalized regenerative medicine. However, the majority of research to date that has utilized stem cells has employed genetically…