Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Brian Kim · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $287,644 — PROJECT SUMMARY/ABSTRACT This new T32 application entitled Research Training in Systems Skin Biology is a combined pre- and post- doctoral training program (MPIs Kim and Millar Co-PDs). The rationale for this proposal is that Icahn School of Medicine at Mount Sinai (ISMMS) has a track record of succ…
MITCHELL A. LAZAR · UNIVERSITY OF PENNSYLVANIA · 2024 · $556,221 — Circadian misalignment has deleterious effects on metabolism, and contributes to the obesity and diabetes epidemics in the United States. REV-ERB nuclear receptors link the circadian clock and metabolism, and the present proposal combines tissue-specific, genome-wide analysis of cistromes, transcrip…
Vasiliki Michopoulos · EMORY UNIVERSITY · 2024 · $743,261 — Summary The cumulative rate of repeated trauma exposure is greater in Black communities of urban, low socioeconomic status and is associated with increased prevalence of adverse, posttraumatic mental health outcomes, including posttraumatic stress disorder (PTSD). PTSD is associated with trauma-rela…
Lawrence P. Kane · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $66,992 — PROJECT SUMMARY Activated CD8+ T cells are capable of responding to tumor neoantigens and can aid in the clearance of tumors. Indeed, CD8+ T cells are critical for the beneficial effects of immune checkpoint blockade therapies, in those patients that respond to such therapies (mAb’s to CTLA-4, PD-1/…
Lin Han · DREXEL UNIVERSITY · 2024 · $584,434 — ABSTRACT Osteoarthritis (OA) is characterized by the irreversible breakdown of cartilage extracellular matrix (ECM). Current regenerative strategies cannot fully restore the biomechanical functions of cartilage, as they do not fully recapitulate the collagen fibrillar architecture of native ECM. Thi…
Jose Francisco Abisambra · UNIVERSITY OF FLORIDA · 2024 · $566,154 — Abstract There is a fundamental gap in understanding how mutations on P301 of tau cause memory impairment in fronto-temporal dementia (FTD). One pathological mechanism involves the association of aberrant tau with ribosomal complexes. However, the consequences of this interaction are unknown. The l…
Catalina Lee Chang · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $347,701 — PROJECT SUMMARY/ABSTRACT Immunotherapy has revolutionized the treatment of many tumors. However, most GBM patients have not, so far, benefited from immunotherapeutic treatment. With the goal of exploring ways to boost anti-GBM immunity, we've developed a B-cell-based vaccine (BVax) that consists of …
Anil Kumar Chauhan · UNIVERSITY OF IOWA · 2024 · $743,663 — Project summary Cardiovascular disease (CVD) and stroke claim more lives than all forms of cancer combined and result in an immense health and economic burden (>$316 billion annually in the United States). Current strategies to prevent acute coronary syndromes and ischemic stroke in at risk patients…
Maggie A Stanislawski · UNIVERSITY OF COLORADO DENVER · 2024 · $158,779 — PROJECT SUMMARY The development of cardiovascular disease (CVD) is a complex process, with obesity being a major risk factor. Weight loss among overweight/obese individuals is a key component of the primary prevention of CVD, but there is marked variability across individuals in response to lifestyl…
DARA S MANOACH · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $839,733 — Memory impairment is a core, disabling feature of schizophrenia, yet we lack effective treatments. A major limitation of efforts to understand and treat memory impairment is that memory is generally assessed during a single session. This approach misses the critical, and arguably most important, asp…
Gianpietro Dotti · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $556,817 — ABSTRACT Remarkable clinical responses have been reported in B-cell malignancies by adoptive transfer of T cells redirected with a chimeric antigen receptor (CAR) specific for the CD19 antigen. However, developing CAR-Ts for the treatment of solid tumors including ovarian cancer (OC) is challenging …
William S Hlavacek · YALE UNIVERSITY · 2024 · $643,676 — PROJECT SUMMARY/ABSTRACT Small molecule inhibitors targeting the RAF/MEK/ERK pathway have become potent tools in precision medicine, but their clinical efficacy is highly variable across the diversity of RAS- and BRAF-mutated cancers. Even in susceptible cancers, these inhibitors rarely give durable…
Kristen Keon Ciombor · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $462,912 — PROJECT SUMMARY/ABSTRACT Vanderbilt-Ingram Cancer Center (VICC) is a matrix cancer center within Vanderbilt University Medical Center (VUMC). VICC has been part of the cooperative group system for over 27 years, and a Lead Academic Participating Site since the inception of the National Clinical Tria…
Shruthi Mahalingaiah · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $561,279 — Per- and polyfluoroalkyl substances (PFAS) are ubiquitous environmental toxicants that are associated with adverse health outcomes including cancer and thyroid disease. The potential for PFAS exposures to negatively influence human health has generated significant concerns in scientific, governmenta…
MERYL Susan LEBOFF · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $670,395 — ABSTRACT Falls and decreased physical function increase markedly with age and result in injury, hospitalization, and death. Safe, cost-effective primary prevention strategies are needed to reduce these adverse outcomes in the aging U.S. population. Basic, preclinical, and clinical studies suggest th…
Brenda McCowan · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $682,055 — Project Summary Social life profoundly influences health. The ability to treat and prevent illness and improve human health therefore requires a detailed understanding of the complex mechanisms underlying the influence of social complexity on biological systems. Such understanding is key to the deve…
Shana M Augustin · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $222,978 — Neuromodulation is crucial for information processing throughout the brain. Neuromodulators influence neuronal function by acting through G protein-coupled receptors (GPCRs) to alter neuronal excitability and synaptic transmission, which can then affect circuit functions. GPCRs are major drug target…
Curt Daniel Sigmund · MEDICAL COLLEGE OF WISCONSIN · 2024 · $905,520 — Summary/Abstract Blood vessels play an important role in the regulation of arterial blood pressure (BP). Precise BP regulation requires coordination between vasodilator and vasoconstrictor signals in the endothelium (EC) and smooth muscle (SMC). EC-derived nitric oxide (NO) is among the key signals …
Matthew Ng Poy · JOHNS HOPKINS UNIVERSITY · 2024 · $392,998 — PROJECT SUMMARY Critical to successful innovation in treating diabetes is the development of strategies for promoting insulin release and preventing pancreatic beta-cell destruction. Chronic demand for insulin production during insulin resistance and diabetes exacerbates cell dysfunction and this i…
Lorraine I Kelley-Quon · CHILDREN'S HOSPITAL OF LOS ANGELES · 2024 · $605,870 — PROJECT SUMMARY Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the risk of short- and long-term morbidity. The duration and type of…