Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
LIWANG CUI · UNIVERSITY OF SOUTH FLORIDA · 2024 · $246,408 — Project Summary Malaria in the Greater Mekong Subregion (GMS) of Southeast Asia remains an important public health problem. Motivated by recent achievements in the reduction of malaria-related morbidity and mortality, six GMS countries have endorsed a regional malaria elimination plan with the ultim…
RONALD G GREGG · UNIVERSITY OF LOUISVILLE · 2024 · $568,819 — Autosomal dominant Retinitis pigmentosa (adRP) is a blinding eye disease that results in loss of rods and eventually cone photoreceptors. A large fraction of adRP is caused by mutations in the rhodopsin (Rho) gene, and the most common mutation in North America causes a P23H mutation in rhodopsin. Pa…
Shan Qiao · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $698,073 — Abstract The global COVID-19 pandemic has imposed unprecedented pressure on health systems and has interrupted public health efforts for other major health conditions, including HIV. HIV service interruptions in the forms of redeployment of staff, reallocation of resources, lack of equipment and med…
Guowei Wei · MICHIGAN STATE UNIVERSITY · 2024 · $544,602 — Project Summary Due to massive vaccination, coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been partially under control. However, emerging contagious variants such as Delta are still fueling new waves of infections around t…
Rami Kantor · MIRIAM HOSPITAL · 2024 · $196,366 — HIV Drug Resistance, Monitoring and Transmission Rami Kantor, MD SUMMARY My career passions have always been mentoring in and conducting HIV-related patient-oriented research. I’ve developed a multidisciplinary research portfolio, combining patient care with clinical, laboratory and bioinformatics t…
INGRID M LIBMAN · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $251,488 — Abstract Diabetes self-management education and support (DSMES) is considered a cornerstone of care and essential in helping people navigate self-management decisions and activities. Despite evidence that DSMES is a critical component of diabetes care, participation remains low. Emerging adulthood (…
STEVEN A BENNER · FOUNDATION FOR APPLIED MOLECULAR EVOLUTN · 2024 · $313,900 — ABSTRACT Under PAR-19-253, the NIGMS seeks new technologies that create a positive feedback loop that drives science forward by allowing new questions to be asked and new discoveries to be made, which in turn drives the development of new technologies. The Benner group has, for 30 years, contribute…
Brion S Maher · JOHNS HOPKINS UNIVERSITY · 2024 · $928,646 — Alzheimer’s disease is a major threat to public health. Because Alzheimer’s disease has no cure, it is critical to identify its modifiable risk factors that can be targeted to reduce its burden. Although initial evidence suggests its plausibility, relatively little attention has been paid to the rol…
ALAN S PERELSON · LOYOLA UNIVERSITY CHICAGO · 2024 · $632,809 — Hepatitis C virus (HCV) is a hepatotropic virus that establishes chronic infection in ~70% of those exposed. As a result, currently more than 71 million people worldwide are infected and at increased risk of developing liver disease and hepatocellular carcinoma. While effective interferon (IFN)-free…
FRANK R LIN · JOHNS HOPKINS UNIVERSITY · 2024 · $611,956 — PROJECT SUMMARY Hearing loss is a chronic condition prevalent in two-thirds of adults >70 years and may be a potentially modifiable risk factor for adverse health outcomes including dementia. However, uptake and sustained use of hearing aids in adults is low, with <20% of older adults with hearing l…
David A. Hafler · YALE UNIVERSITY · 2024 · $1,060,433 — ABSTRACT We propose a deep interrogation and a systems approach that will identify molecular signatures to vaccination across three cohorts of vulnerable patient populations: autoimmune patients with B cell depletion, aged and frail individuals, and patients with sickle cell disease who are functio…
CHING-LONG LIN · UNIVERSITY OF IOWA · 2024 · $731,422 — PROJECT SUMMARY Patients who recover from the novel coronavirus disease 2019 (COVID-19) may experience a range of long- term health consequences. Since the lung is the primary site of viral infection, pulmonary sequelae may present persistently in COVID-19 survivors. Thus, clinical assessment of COV…
Sato Ashida · UNIVERSITY OF IOWA · 2024 · $604,101 — Individuals with Alzheimer’s disease or related dementias (ADRD) and their families are especially vulnerable during a disaster. Disasters it limit caregivers’ ability to continue with care due to disaster related stress and reduced access to resources and support. The COVID-19 pandemic showed the e…
Matthew Akiyama · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $636,855 — Abstract. The United States (U.S.) has experienced higher mortality than any other nation due to COVID-19 with nearly 13.5 million cases and over 268,103 deaths. Due to the limited ability to socially distance, poor ventilation, and limited hygiene supplies, U.S. prisons and jails have observed exp…
Scott Holmes · BOSTON CHILDREN'S HOSPITAL · 2024 · $523,414 — Chronic pain experienced by children has the potential to persist into adulthood and drive drug addiction, mental health problems and suicidal behavior. The level of pain reported by children who experience headache is immense and likely poorly estimated based on lowered ability of children to artic…
Elliot J. Lefkowitz · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $319,000 — PROJECT SUMMARY/ABSTRACT Viruses are able to infect every kind of organism on the planet. They play an integral part in maintaining normal ecosystems but sometimes cause perturbations that have adverse impacts on human health, agriculture, and the wider environment. Understanding the role that virus…
SARASWATI SUKUMAR · JOHNS HOPKINS UNIVERSITY · 2024 · $533,346 — Abstract. In many low- and middle-income countries (LMICs) breast cancer is diagnosed at advanced stages. Many women present with a palpable breast mass, which is rare in communities where breast screening is available. In addition to limited imaging facilities, prolonged diagnostic delays (76-630 d…
Xiaobo Zhou · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $312,000 — Abstract The goal of this project is to develop a platform called mRNAdesigner, an integrated deep learning model to optimize 5'UTR, codon usage, and 3'UTR at same time, which enables users to design the optimal mRNA sequence to enhance protein expression level, thus to improve the mRNA translation …
Meghan Elizabeth Rebuli · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $607,668 — PROJECT SUMMARY Wildfire smoke increasingly contributes to ambient air pollution and more specifically PM2.5 and has been associated with increased respiratory virus morbidity and mortality. We have previously shown that exposure of human volunteers to woodsmoke (WS) significantly modifies acute ant…
Leanne M Boehm · VANDERBILT UNIVERSITY · 2024 · $781,969 — Approximately 33-50% of intensive care unit (ICU) survivors develop long-term cognitive impairment – a well-established form of Alzheimer’s Disease Related Dementia (ADRD). ICU-acquired ADRD prevalence is especially high in acute respiratory distress syndrome and sepsis survivors, affecting up to 80…