Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tony Y. Hu · TULANE UNIVERSITY OF LOUISIANA · 2024 · $726,852 — ABSTRACT Every year 10 million people fall ill with tuberculosis (TB) and 1.5 million people die from TB – making it the leading cause of death from infectious disease – but TB can be difficult to diagnose. Extended M. tuberculosis (Mtb) cultures are still often used for diagnosis. PCR-based assays …
Daniel Hal Solomon · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $891,115 — PROJECT SUMMARY The overarching long-term aims of VERITY are: 1) to develop state-of-the-art methods for clinical research in rheumatology and musculoskeletal diseases that are relevant for the Research Community, 2) to deliver methodologic and bioinformatic assistance to the Research Community, and…
Rachel Gatlin · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $33,209 — Project Summary/Abstract As social creatures, social interaction is vital for mammalian health. Prolonged separation from social environments can result in social isolation stress, which is linked to poor mental health outcomes, including anxiety, depression, and violence. Despite this, relatively l…
Z Hong ZHOU · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $95,491 — Double-stranded RNA (dsRNA) viruses comprise a large group of non-enveloped viruses characterized by their ability to transcribe their RNA within an intact capsid (i.e., endogenous RNA transcription), thus evading cellular antiviral responses to dsRNA. Among them, members of the Reoviridae family of…
John Daniel Kelly · VETERANS AFFAIRS MED CTR SAN FRANCISCO · 2024 — As SARS-CoV-2 vaccines enter mass distribution, little is known about vaccinated individuals who nonetheless develop Covid-19 (symptomatic disease or “vaccine failure”), require hospitalization, and die. Pfizer-BioNTech reported 3.8 vaccine failure cases/1,000 person-years, meaning vaccine failure w…
Lee H Harrison · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $777,266 — Project Summary Despite recent progress in reducing the incidence of healthcare-associated infections (HAIs), the Centers for Disease Control and Prevention estimated that 687,000 HAIs occurred in U.S. acute care hospitals in 2015 and that the HAI prevalence on a given day was one in 30 patients. An…
PETER PHILIP REESE · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $485,000 — PROJECT SUMMARY Urinary Stone Disease (USD) is an increasingly prevalent and highly recurrent condition associated with major morbidity at a rising cost to society. Thus, improved management can significantly reduce its health burden. Increasing fluid intake is recommended to all USD patients. Howev…
ASHOK K CHOPRA · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $757,093 — ABSTRACT The increasing number of bubonic/pneumonic plague cases globally (2010-2018), including the U.S., with a ~18% case fatality rate may reflect climate changes and a rodent carrier range shift. The 2017-18 plague outbreak in Madagascar with ~2400 cases (>75% pneumonic) and ~9% causalities has …
SEBASTIAN JOYCE · VETERANS HEALTH ADMINISTRATION · 2024 — The overarching goal of my research program is to understand tissue specific immunity with focus on the lungs. Immune cells continuously surveil the lungs to respond quickly to infections. Mycobacterium tuberculosis (Mtb) causes chronic tuberculosis (TB) and Francisella tularensis causes acute tular…
Raouf S. Amin · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $944,438 — PROJECT SUMMARY – OVERVIEW Cystic Fibrosis results from the absence or dysfunction of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. Defects in CFTR are strongly associated with genetic variations in the CFTR gene that are unique to individual CF patients or to subg…
Yehia Mechref · TEXAS TECH UNIVERSITY · 2024 · $302,855 — Glycosylation is one of the most complex protein modifications; more than 50% of mammalian proteins are glycosylated. The fact that there are 100,000 proteoforms coded by only ~20,300 genes identified in the human genome emphasizes the importance of posttranslational modifications (PTMs) like glycos…
Mark J Van Ryzin · UNIVERSITY OF OREGON · 2024 · $707,157 — Abstract Internalizing symptoms (i.e., anxiety, depressive symptoms, suicidality) are alarmingly common among adolescents. In 2019, nearly 37% of high school students reported feeling anxious, sad, or hopeless, representing an increase from 2017 (i.e., 31%), and nearly 19% seriously considered suici…
Yi-Chih Lin · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $389,821 — Abstract: Spike glycoprotein (S-protein) is one of the viral transmembrane proteins on the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes the coronavirus disease 2019 (COVID-19). S- protein plays a crucial role in mediating the initial entry of viral genome i…
Kelly Corinne Young-Wolff · KAISER FOUNDATION RESEARCH INSTITUTE · 2024 · $659,404 — PROJECT SUMMARY/ABSTRACT Importance of the proposed research. Prenatal cannabis use is increasingly common and could have largescale negative impacts on maternal and fetal health. Legalization of cannabis has led to the proliferation of new cannabis products with various modes of administration (e.g…
MIN ZHANG · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $324,000 — PROJECT SUMMARY This project, focused on biomedical big data analysis in cancer research, represents a response to the ongoing need for initiatives that enhance the capabilities of researchers in the field. As the volume and complexity of cancer-related data continue to grow, equipping researchers w…
Stanca M. Ciupe · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $278,462 — The emergence and re-emergence of pathogens and their impact on society has reinforced the need for integration and synergy across scientific fields and biological scales in order to advance understanding, predicting, and responding to pathogen spread. Multi-scale mathematical models that consider…
Rishi Kumar Wadhera · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $806,086 — PROJECT SUMMARY/ABSTRACT In the US, working-age adults (age 20 to 64 years) in rural areas experience significantly higher cardiovascular (CV) mortality rates than their urban counterparts due to worse access to care and a greater burden of risk factors. The COVID-19 pandemic threatens to further wi…
Sharla Maelyn Wells-Di Gregorio · OHIO STATE UNIVERSITY · 2024 · $656,014 — Abstract People with advanced cancer experience a greater frequency and severity of physical and psychological symptoms, ranking sleep difficulties, worry-anxiety, depression, and fatigue as four of the most common and distressing symptoms. These symptoms form a symptom cluster, contribute to functi…
MARTHA E WADSWORTH · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $914,649 — PROJECT SUMMARY Levels of adolescent anxiety, depression, and suicidality have been steadily rising over the last decade and have reached record levels in the wake of the COVID pandemic, prompting declarations of a national emergency in youth mental health. These alarming trends are especially dram…
Guoyun Chen · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $462,000 — Sepsis is a systemic inflammatory response syndrome initiated by infection. Most cases of septic shock are caused by Gram-negative bacteria, including Escherichia coli (E. coli), which remains one of the most common pathogens leading to sepsis. Understanding the mechanisms by which the mammalian imm…