Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Fei Yin · UNIVERSITY OF ARIZONA · 2024 · $378,537 — PROJECT SUMMARY Late onset Alzheimer’s disease (LOAD) is a neurodegenerative disease with a multifactorial etiology and intersecting genetic and environmental risks, making it a complex systems challenge. Brain functions are highly energy-dependent, with most of which generated by mitochondria via …
E. FIONA BAILEY · UNIVERSITY OF ARIZONA · 2024 · $669,435 — Project Summary Exercise has well-documented benefits for systolic blood pressure (SBP) and cardiovascular health. Whereas current guidelines advocate ~150 min moderate intensity exercise/week, our preliminary data show ~5 min/day of inspiratory muscle strength training (IMST) for 6 weeks lowers cas…
Yael Schenker · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $433,613 — Abstract Summary: Failure to deliver care near the end of life that reflects the needs, values and preferences of patients with advanced cancer remains a key shortcoming of our cancer care delivery system. National organizations including the National Academy of Medicine and American Society of Clin…
Brant E Isakson · UNIVERSITY OF VIRGINIA · 2024 · $1,042,148 — Despite decades of research there are still fundamental gaps in our knowledge of the underlying mechanisms that contribute to development and progression of most cardiovascular (CV) diseases, as well as the end stage clinical consequences of these diseases and how to better treat or prevent them. A …
Prasad V Katakam · TULANE UNIVERSITY OF LOUISIANA · 2024 · $463,813 — Summary Brain microvessels play an important role in the neurovascular coupling (NVC). Mitochondria are energy sensors of cells. My work for the first time demonstrated the link between mitochondrial depolarization and activation of nitric oxide synthases (NOS). Recently, we have made a novel discov…
Hasan Zaki · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $524,056 — SUMMARY Lipid and cholesterol-rich Western diet is a major risk factor for many non-communicable diseases, including cardiovascular disease, obesity, diabetes, metabolic syndrome, and inflammatory bowel disease (IBD). A common lipid derivative associated with the pathogenesis of these inflammatory a…
Premal S Trivedi · UNIVERSITY OF COLORADO DENVER · 2024 · $187,332 — PROJECT SUMMARY/ABSTRACT As a vascular and interventional radiologist and a health services researcher, my long-term goal is to achieve transformative improvements in vascular procedural care through national quality of care assessments and implementing pragmatic inventions to improve outcomes. This…
Sheria Grice Robinson-Lane · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $127,411 — PROJECT SUMMARY/ ABSTRACT Black family caregivers of older adults with Alzheimer’s disease and/or related dementias (ADRD), have an increased mortality risk related to pre-existing health conditions and stress. Targeted, community-based health interventions that help Black ADRD caregivers to effecti…
Karla Washington · WASHINGTON UNIVERSITY · 2024 · $605,267 — ABSTRACT In recent decades, the primary setting for oncology treatment has shifted from the hospital inpatient unit to the outpatient clinic, leaving nearly 4.6 million family caregivers responsible for most of the day-to-day, round-the- clock cancer care provided in the United States. Cancer caregi…
Freya Mowat · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $431,435 — The co-occurrence of age-related cognitive and sensory organ impairments exacerbates negative effects on the health, lifestyle, and quality of life of older adults. These age-related multimorbidities include Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD), in addition to sens…
Benjamin Deneen · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $591,375 — SUMMARY Transcriptional networks in cancer are a collection of inputs from developmental and cell identity programs, oncogenic proteins, metabolic circuits, and micro-environmental interactions. Together, these culminate to drive disparate stages of tumor initiation, maintenance, and progression. Ep…
Joanne G Patterson · OHIO STATE UNIVERSITY · 2024 · $248,993 — PROJECT SUMMARY Polytobacco use, defined as concurrent use of more than one tobacco product including electronic nicotine delivery systems (ENDS), is rising and high in lesbian, gay, bisexual, and transgender (LGBT) young adults (YA). Between 22-40% of LGBT YA (vs 12-21% of non-LGBT YA) report past …
Satdarshan Singh Monga · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $615,393 — Chronic cholestasis results from bile secretory defects or impairment of bile flow, and there are few effective medical therapies available. During the past funding period, we have made significant progress in determining the multifactorial role of the Wnt/β-catenin pathway in cholestatic liver dise…
Jiexi Chen · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $45,336 — Project Summary/Abstract The marine pathogen Vibrio vulnificus is a highly lethal Gram-negative bacteria inhabiting coastal waters. It causes intestinal infections via consumption of raw seafood and wound infections via open wounds. The infection progresses rapidly to septicemia with high fatality r…
MICHAEL E TALKOWSKI · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $705,513 — ABSTRACT Emerging genomic medicine initiatives are poised to impact prenatal and pediatric diagnostics, including assessment of fetal structural anomalies (FSAs) from amniocentesis and the rapid adoption of non-invasive prenatal screening (NIPS). Indeed, the rapid decrease in whole-genome sequencing…
Gary E Schiltz · LOYOLA UNIVERSITY CHICAGO · 2024 · $487,318 — PROJECT SUMMARY This R01 renewal proposal intends to extend the PI's past productivity that includes 35 publications since the year, 2016, including 3 senior-authored manuscripts in Clinical Cancer Research and 2 additional bodies of work that are under review in Neuro-Oncology and Nature. The scien…
Larissa A. Shimoda · JOHNS HOPKINS UNIVERSITY · 2024 · $718,982 — PROJECT SUMMARY Pulmonary arterial hypertension (PAH) is a severely debilitating disease with no cure. Morphometric studies revealed that the development of pulmonary hypertension is associated with robust structural remodeling of the small pulmonary arteries, characterized by thickening of the end…
Avinash Das Sahu · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $217,810 — PROJECT SUMMARY Avinash D Sahu, Ph.D., is a computational biologist whose overarching career goal is to solve longstanding problems in cancer immunology and translational precision oncology using artificial intelligence (AI) and to devise new therapeutic strategies for late-stage cancer patients. En…
Michael Andrew Schumacher · CHILDREN'S HOSPITAL OF LOS ANGELES · 2024 · $157,540 — PROJECT SUMMARY Deep crypt secretory (DCS) cells are an understudied lineage of secretory cells residing in the colonic crypt base with unknown roles in colitis. In preliminary data, I show that DCS cells express a class of proteins known as host defense peptides (HDPs) that can influence key epithe…
Alka Dev · DARTMOUTH COLLEGE · 2024 · $136,350 — PROJECT SUMMARY (ABSTRACT) People with disabilities experience pregnancy at the same rate as people without disabilities but have disproportionately higher rates of adverse outcomes including pregnancy, labor and delivery complications, severe maternal morbidity, maternal death, preterm birth, still…