Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Siddhartha De · 7 HILLS PHARMA, LLC · 2024 · $953,477 — PROJECT SUMMARY/ABSTRACT Americans aged ≥65 years accounted for 57% and 75% of all influenza-related hospitalizations and deaths, respectively, in the 2019-20 season, despite a vaccination rate of ~68%. Flu vaccine effectiveness is lower in the elderly than in younger adults, requiring either a high…
Lisa L Barnes · RUSH UNIVERSITY MEDICAL CENTER · 2024 · $2,287,199 — ABSTRACT The prevention of Alzheimer’s dementia and cognitive decline in our aging population is a major public health priority. Older Black adults are disproportionately burdened by Alzheimer’s dementia compared to other racial and ethnic groups. Reasons for the increased burden are unknown and tra…
Xiaoming Li · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2024 · $313,332 — ABSTRACT With the increase of healthcare-related Big Data, such as electronic health records (EHR), social media, wearable devices, genomic data, and other digital records of information pertinent to individual and population health, Big Data science has brought forth revolutionary advancements in m…
Julie A. Baldwin · NORTHERN ARIZONA UNIVERSITY · 2024 · $4,329,719 — PROJECT SUMMARY The overall goal of the Southwest Health Equity Research Collaborative (SHERC) is to increase basic biomedical, clinical, and behavioral research at Northern Arizona University (NAU) to address health disparities and advance health equity among diverse populations of the southwestern…
Nadine Georges Rouphael · EMORY UNIVERSITY · 2024 · $455,761 — ABSTRACT The overarching goal of the Emory Stimulating Access to Research in Residency R38 (Emory R38) program is to leverage the rich infrastructure and the interdisciplinary research environment at Emory University to provide > 12 months of clinical and translational research training for resident…
Scott C Weaver · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $1,506,495 — Arthropod-borne viruses (arboviruses) such as chikungunya (CHIKV) and Zika (ZIKV), as well as rodent- and bat-borne viruses such as Lassa fever and probably Ebola, are among the most important causes of emerging infectious diseases, and many circulate enzootically in W. Africa. The mechanisms whereb…
Luyao Lu · GEORGE WASHINGTON UNIVERSITY · 2024 · $541,251 — Project Summary The goal of this R01 proposal is to develop an ultra-soft, fully implantable, wireless label-free cardiac mapping and modulation system and apply it to identify chronic electrophysiological and metabolic changes and their links during heart failure (HF) development, progression, and …
Theresa Ryckman · JOHNS HOPKINS UNIVERSITY · 2024 · $121,500 — PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) remains a leading cause of global mortality. Treatment is efficacious and low cost for most people, but clinic-based (“passive”) case detection leaves millions of people with TB undiagnosed every year. To accelerate progress against TB, we must bring detect…
Kara Elizabeth Rudolph · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $584,911 — The opioid epidemic in the US is a public health emergency, exacerbated by the Covid-19 pandemic. Medi- cations for opioid use disorder (MOUD)-injection naltrexone, buprenorphine, and methadone-are the most effective tools for improving outcomes and preventing overdose among persons with OUD, but en…
Gabrielle Entrup · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $24,847 — Project Abstract Obesity is a major global public health concern. Worldwide, 39% of the population is overweight and 13% of the population is obese. Obesity contributes to many other diseases, such as heart disease, stroke, some cancers, and notably, type 2 diabetes (T2D). Currently, 425 million peo…
Leah Ren-Ai Koenig · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $37,836 — Project Summary This mentored Ruth L. Kirschstein National Research Service Award will provide the trainee, a PhD student in epidemiology at UCSF, with the training necessary to become a researcher in sexual and reproductive health. Her training goals for this fellowship are to gain expertise in hea…
Shao Lin · STATE UNIVERSITY OF NEW YORK AT ALBANY · 2024 · $401,135 — PROJECT SUMMARY / ABSTRACT In recent decades, climate change has contributed to more frequent and extreme weather-related disasters (EWRD), such as heatwaves, floods, hurricanes, storms and power outage (PO). The impact of these EWRDs on human health has become a top public health priority. Research…
David Richard Light · ILLEXCOR THERAPEUTICS, LLC · 2024 · $807,795 — Acute respiratory distress syndrome (ARDS) is a life-threatening condition featuring acute onset of non- cardiogenic respiratory failure and hypoxemia. Consequently, patients with ARDS have severe hypoxemia due to a significant impairment of gas exchange, and the goal of supportive therapy is to pre…
Andrew Leon Kau · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $669,712 — PROJECT SUMMARY The gut microbiome has a profound effect on human health by influencing the development of the immune system, producing bioactive metabolites and directly aiding in the processing of food. Changes in the composition and metabolism of the gut microbial community has been associated wi…
Stefan Worgall · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $799,479 — PROJECT SUMMARY SARS-CoV-2 infections in children are mostly milder and less lethal than in adults. This lower incidence of relevant disease associated with SARS-CoV-2 has surprisingly also been observed for children with asthma, the most common chronic respiratory and inflammatory disease in childr…
Anthony Tao · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $53,974 — PROJECT SUMMARY/ABSTRACT B cells are a central player in the humoral immune response, which is elicited by differentiated, antibody- producing B cell-types known as plasma cells (PCs). During viral infections such as influenza or SARS-CoV2, PCs produce antibodies that neutralize viral activity. Furt…
Felicia Amira Browne · RESEARCH TRIANGLE INSTITUTE · 2024 · $610,495 — PROJECT SUMMARY/ABSTRACT The intersection between alcohol and other drug (AOD) use among young African American women at risk for HIV is a public health issue. Recent epidemiological data highlight increases in alcohol misuse among young African American women, especially since COVID-19. These issu…
Jamie Jon Arnold · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $404,270 — Abstract The RNA-dependent RNA polymerase (RdRp) drives viral evolution by mediating both genetic drift (mutation) and genetic/antigenic shift (recombination) of RNA viruses. RdRp speed and fidelity contribute to the rate of mutation and formation of the mutant swarm, a well-established determinant …
Alicia S Kunin-Batson · UNIVERSITY OF MINNESOTA · 2024 · $643,287 — Project Summary/Abstract The COVID-19 pandemic has had an alarming impact on already unacceptably high childhood obesity rates, and emerging evidence shows that traditional approaches to pediatric weight management have been markedly less effective since the onset of the pandemic. As obesity during …
Nicola Pozzi · SAINT LOUIS UNIVERSITY · 2024 · $227,250 — Project summary This project aims to investigate a novel approach to mitigate the risk of vascular thromboses, which imposes a significant economic burden in the US. Our strategy is to develop a technology that, by specifically targeting the lipid-binding domains of factor X (read factor ten) and pr…