Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Melissa Ariel Walsh · UNIVERSITY OF MINNESOTA · 2024 · $43,262 — PROJECT SUMMARY/ABSTRACT Natural killer (NK) cell engagers are a promising anticancer therapy that potently leverages the immune system while providing an exceptional safety profile. Trispecific killer cell engagers (TriKEs) are NK cell engagers that mediate NK cell killing of tumor cells through mu…
Melody Faith Schwenk · GALLAUDET UNIVERSITY · 2024 · $48,974 — Project Summary/Abstract This research proposal focuses on the relationship between American Sign Language (ASL) fluency and spatial cognition, an area encompassing skills like perspective-taking, spatial navigation, and orientation.Spatial cognition is fundamental to everyday life, influencing how…
Wu-Min Deng · TULANE UNIVERSITY OF LOUISIANA · 2024 · $341,248 — Project Summary Ploidy variation is a cancer hallmark and is frequently associated with poor prognosis in high-grade cancers. Such variation can include an increase in chromosome set (polyploidy), a difference of chromosomes in a set (aneuploidy), or regional ploidy changes and copy number variation…
Natalie Hawken · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $41,308 — PROJECT SUMMARY/ABSTRACT Autism spectrum disorder (ASD) is a lifelong, common neurodevelopmental disorder (NDD) with high heritability and complex genetic architecture. Known genetic risk factors, including large effect, de novo mutations that cause approximately 10% of ASD cases, have their maximal…
Rose Khavari · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $10,000 — Abstract Neurogenic lower urinary tract dysfunction (NLUTD), formerly “neurogenic bladder,” encompasses bladder and sphincter abnormalities resulting from neuromuscular diseases or injuries. Conditions such as cerebrovascular accidents (CVAs), spinal cord injuries (SCIs), and age-related neurogenera…
Saher Sue Hammoud · WAYNE STATE UNIVERSITY · 2024 · $658,633 — Natural fertilization and embryo development require heathy spermatozoa to carry male genetic material to fertilize the egg. During the final phase of spermatogenesis, the spermatids undergo dramatic changes including the formation of the flagella, condensation of chromatin and so on. A spermatid-sp…
Qi Chen · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $703,373 — Project summary: Increasing lines of evidence in mammals have shown that certain acquired traits during paternal environmental exposure (e.g., unhealthy diet) can be “memorized” in sperm and transmitted to the future generations without altering the DNA sequence. Our research seeks to unravel the ep…
Benjamin Elison Gewurz · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $20,250 — ABSTRACT This conference grant application requests funds to help support the 2024 International Conference on EBV & KSHV. The conference will be held at the Boston Park Plaza Hotel. This joint conference is unique and innovative in that it combines the International Workshop on Kaposi’s Sarcoma-Ass…
Ravi Ranjan · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $763,469 — Ventricular tachycardia can be a life-threatening arrhythmia that requires effective and timely treatment. This treatment often takes the form of catheter based ablation; however, the success rates are modest. Moreover, the ablation procedure is invasive, done under general anesthesia, and can take …
Rafi Ahmed · EMORY UNIVERSITY · 2024 · $620,693 — Chronic viral infections are characterized by a state of T cell dysfunction that is associated with expression of the PD-1 (programmed cell death 1) inhibitory receptor. A better understanding of the mechanisms that regulate CD8 T cell responses during chronic viral infection is required to improve …
Suzanne M Cloonan · BAYLOR COLLEGE OF MEDICINE · 2024 · $796,760 — Abstract We have previously shown that metformin, a biguanide commonly used for the treatment of type 2 diabetes, has robust protective effects against cigarette smoke (CS)- induced lung pathologies including accelerated aging, apoptosis, inflammation, and oxidative stress in mice and in individuals…
Nisha Aggarwal Gilotra · JOHNS HOPKINS UNIVERSITY · 2024 · $50,000 — PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational, and clinical approaches, the Americas Association of Sarcoidosis and Other Granulomatous Disorders (AASOG) 2024 Scientific Conference, entitled “The Art of Working Together for Progress,” will focus on a central qu…
Brendan Lee · AMERICAN SOCIETY FOR BONE & MINERAL RES · 2024 · $45,000 — The American Society for Bone and Mineral Research (ASBMR) is the largest professional, scientific and medical society established to bring together clinical and laboratory-based investigators who are involved in the study of bone, mineral and musculoskeletal disorders. Since 2002, the ASBMR has hel…
STEPHANIE A. PANGAS · BAYLOR COLLEGE OF MEDICINE · 2024 · $10,000 — Abstract Central to the mission of the Fertility and Infertility Branch of NICHD is advancing women's reproductive health through support for basic and translational research. The XXIII Ovarian Workshop serves as a dynamic platform for fostering collaboration and sharing research progress among basi…
Allen Po-Chih Liu · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $15,175 — Project summary Our abilities to engineer synthetic cell systems that can communicate with living cells remain limited. The long-term goal is to engineer cell-like systems with increasingly complex biomimetic functions that can serve as cell replacements or augment functions of natural cells. The ob…
Daniel Q Sun · UNIVERSITY OF CINCINNATI · 2024 · $200,880 — Abstract I am a neurotologist and assistant professor in the department of Otolaryngology-Head and Neck Surgery at the Johns Hopkins University School of Medicine. I am applying for a K08 mentored surgeon-scientist career development award (CDA) to obtain further training related to chemical enginee…
Margaret Lise Gardel · UNIVERSITY OF CHICAGO · 2024 · $199,024 — Project Summary Mechanisms of Mechanotransduction by LIM Domain Proteins Mechanical forces are essential to controlling the shape, movement and even many aspects of cell physiology. Changes in the environment mechanics or defects in cellular mechanoresponse are implicated in a plethora of diseases i…
Prajakta Adsul · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $629,068 — PROJECT ABSTRACT Each year, more than 500,000 women are diagnosed with cervical cancer (CxCa), a preventable cancer caused by human papillomavirus (HPV) that disproportionately burdens low- and middle-income countries (LMICs). Women living with HIV (WLHIV) are up to six times more likely to develop …
Robert A Battaglia · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $3,000 — PROJECT SUMMARY/ABSTRACT Across all life, gene expression depends upon the faithful and timely transcription of messenger RNAs by RNA polymerase. The molecular details of RNA polymerase (RNAP) elongation have been determined for enzymes from a few species, but it is unclear whether these examples ar…
Mohammed Kumail Ali · EMORY UNIVERSITY · 2024 · $622,558 — ABSTRACT In sub-Saharan Africa (SSA), human papillomavirus (HPV) and HIV create a dual burden of disease that causes significant morbidity and mortality in the form of cervical cancer (CC). Women living with HIV (WLWH) have a six-fold higher risk of developing precancerous lesions that persist and p…