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Principal Investigator: Rose Khavari
Organization: METHODIST HOSPITAL RESEARCH INSTITUTE
Fiscal Year: 2024
Award: $10,000
Funding agency: National Institute of Diabetes and Digestive and Kidney Diseases
Abstract
Neurogenic lower urinary tract dysfunction (NLUTD), formerly “neurogenic bladder,” encompasses bladder and
sphincter abnormalities resulting from neuromuscular diseases or injuries. Conditions such as cerebrovascular
accidents (CVAs), spinal cord injuries (SCIs), and age-related neurogenerative diseases like Alzheimer’s and
other types of dementia contribute to NLUTD1. This condition is prevalent, affecting approximately 15% of stroke
patients and 70-84% of those with spinal cord injuries2. Furthermore, NLUTD is found in 40-90% of individuals
with Multiple Sclerosis (MS), 37-72% in those with Parkinson’s Disease (PD) and has been reported in more
than 90% of children with spina bifida3,4. Urinary incontinence in individuals with dementia escalates in tandem
with the severity of the condition, and except for SCI, aging is the primary risk factor for these neurological
conditions5-7. Patients with NLUTD experience drastic effects on quality of life secondary to the development of
urinary tract infections (UTIs), urinary retention, incontinence, renal dysfunction, and autonomic dysreflexia1.
The Neurogenic Bladder Research Group (NBRG) is an academic society dedicated to improving the lives of
patients with NLUTD through application of patient-centered outcomes research. Sequelae of NLUTD are usually
electively managed with a combination of medications, medical devices and surgical approaches. Recently, more
advanced devices have been employed for management of urinary symptoms associated with NLUTD, including
tibial nerve stimulators and sacral neuromodulation systems. However, while these devices improve the quality
of life for patients with neurogenic urinary symptoms, further research and development is critical to maximize
the efficacy and longevity of urologic technology8,9. The overarching goal of this proposal is to host an NBRG
affiliated meeting, which will be the first of its kind, to identify areas in the management of NLUTD that
would benefit from engineering solutions.
To achieve this theme, in Aim 1, leading researchers in engineering and multiple medical specialties, including
urology, neurology, neurosurgery, and pediatrics – as well as patient representatives – will be invited to
participate in active lectures, group discussion, round tables to identify the gaps in NLUTD care that engineering
solutions can address. In Aim 2, guidelines will be written to outline the role of engineers in neurogenic bladder
care and guide the development of engineering solutions in NLUTD for the near future. In Aim 3, engineering,
doctoral, and medical students and junior investigators will be invited to submit abstracts for presentation to
promote early showcasing and mentorship in NLUTD research. Toward the manifestation of these aims, we are
applying for an R13 conference grant. This timely meeting is in full agreement with the missions of the National
Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute on Aging (NIA). This
conference will the first to bring together engineers and researchers/clinicians to advance technologic solutions
for the care of NLUTD and to compose a series of guiding principles on the subject.
Terms: <0-11 years old><AD dementia><Address><Advertising><Affect><Aging><Agreement><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Apoplexy><Area><Artificial Genitourinary Sphincter><Artificial Urinary Sphincter><Asian><Bladder><Bladder Urinary System><Brain Vascular Accident><Caring><Catheterization><Catheters><Causality><Censuses><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Child><Child Youth><Children (0-21)><Cities><Combination Medication><Committee Members><Communities><Contracting Opportunities><Contracts><County><Dedications><Dementia><Development><Development and Research><Device Designs><Devices><Diabetic Neuropathies><Disease><Disorder><Disseminated Sclerosis><Dysfunction><Engineering><Ensure><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Etiology><Event><Face><Female><Fostering><Foundations><Functional disorder><Funding><Future><General Population><General Public><Goals><Government><Grant><Group Affiliation><Guidelines><Hispanic><Incontinence><Increased frequency of micturition><Individual><Injury><Investigators><Knowledge><Latino><Length of Life><Life Style><Lifestyle><Location><Longevity><Lower urinary tract><MD students><Medical Device><Medical Students><Mentorship><Minority Participation><Mission><Multiple Sclerosis><NIDDK><National Institute of Aging><National Institute of Diabetes and Digestive and Kidney Diseases><National Institute on Aging><Neurogenic Bladder><Neurogenic Bladder Disorder><Neurogenic Urinary Bladder Disorder><Neurologic><Neurological><Neurology><Neuromuscular Diseases><Neuropathic Bladder><Operative Procedures><Operative Surgical Procedures><Outcome><Outcomes Research><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Patient Representative><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pediatrics><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Physiopathology><Population><Primary Parkinsonism><Primary Senile Degenerative Dementia><QOL><Quality of life><R & D><R&D><Racial Group><Recurrence><Recurrent><Reporting><Research><Research Personnel><Researchers><Risk><Risk Factors><Role><Schistorrhachis><Science><Scientist><Secondary to><Series><Severities><Societies><Source><Specialty><Sphincter><Spina Bifida><Spinal Cord Trauma><Spinal Dysraphia><Spinal Dysraphism><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stroke><Structure of tibial nerve><Students><Surgical><Surgical Interventions><Surgical Procedure><Symptoms><System><Technology><Tibial Nerve><Training><Trauma><Traumatic Myelopathy><Travel><Urethra><Urethral Stenosis><Urethral Stricture><Urinary Bladder Neurogenic Dysfunction><Urinary Catheterization><Urinary Frequency><Urinary Incontinence><Urinary Retention><Urinary tract infection><Urinary tract infectious disease><Urology><Writing><age associated><age correlated><age dependent><age linked><age related><age specific><application in practice><associated symptom><brain attack><career><catheterized urine><causation><cerebral vascular accident><cerebrovascular accident><cleft spine><clinical practice><co-morbid symptom><co-occuring symptom><comorbid symptom><concurrent symptom><conference><convention><cooccuring symptom><design><designing><developmental><diabetes-associated neuropathy><disease causation><doctoral student><empowerment><ethnic subgroup><ethnicity group><experience><faces><facial><hydrocele spinalis><improved><injuries><innovate><innovation><innovative><insular sclerosis><interest><kidney dysfunction><kids><lectures><marginalized group><marginalized individual><marginalized people><marginalized population><medical school students><medical specialties><meeting><meetings><member><men><multidisciplinary><myoneural disorder><neural control><neural regulation><neurological pathology><neuromodulation><neuromodulatory><neuromuscular degenerative disorder><neuromuscular disorder><neuroregulation><neurosurgery><pathophysiology><patient oriented outcomes><patient population><practical application><primary degenerative dementia><rachischisis posterior><racial population><racial subgroup><recruit><renal dysfunction><research and development><senile dementia of the Alzheimer type><side effect><skills><social role><stroke patient><stroked><strokes><success><summit><surgery><symposia><symposium><symptom association><symptom comorbidity><technological innovation><urethra stricture><urethral><urinary><urinary bladder><urinary infection><urologic><urological><youngster>