Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DEBORAH DOROSHOW · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $60,000 — Deborah Doroshow, MD, PhD is a medical oncologist and clinical investigator at the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai who specializes in thoracic oncology and histology-agnostic early phase drug development. This application to the Early Career Cancer Clinical Investigat…
JULIAN F. THAYER · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $58,647 — Contact PD/PI: YASSA, MICHAEL PROJECT SUMMARY Anhedonia—the diminished capacity to experience pleasure from normally pleasurable stimuli—is a transdiagnostic symptom of multiple psychiatric disorders, including depression, schizophrenia and post- traumatic stress disorder. The recent and rapid growt…
Joseph Donald Zak · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $92,614 — PROJECT SUMMARY/ABSTRACT To reliably encode information about the environment, neurons must modify their activity profiles and even connectivity to accurately interpret complex stimuli. Cortical feedback projections to the olfactory bulb are uniquely positioned at the interface between detection-ba…
George W Jackson · BASE PAIR BIOTECHNOLOGIES, INC. · 2024 · $751,525 — Project Summary/Abstract The United States is experiencing an epidemic of unprecedented scope with heroin use resurging and a troubling pervasive increase in abuse of prescription opioids such as fentanyl, fentanyl derivatives, methadone, oxycodone and hydrocodone. More than 6 out of 10 drug overdos…
Bruce R. Donald · DUKE UNIVERSITY · 2024 · $39,452 — Project Summary. The determination of three-dimensional protein structures is essential for revealing molecular mechanism of disease processes, and also for structure-based drug design. Concomitantly, technological advances in protein design could revolutionize therapeutic treatment. With these adva…
Bibhav Acharya · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $187,491 — Project Abstract People living with HIV (PLWH) have poor clinical outcomes when they are excluded from care due to intersectional stigma related to HIV, mental health (MH), and other dimensions. Recent studies and reviews have highlighted three major challenges in identifying and addressing intersec…
Grace Ji-eun Shin · OHIO STATE UNIVERSITY · 2024 · $182,231 — PROJECT SUMMARY My career goal is to lead an independent research group to investigate the pathology and resolution of pain to solve neuropathic pain problems. To achieve this goal, I propose to develop and use novel translational strategies to investigate neuron-substrate interactions in the skin …
Virginia Bond · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $185,040 — PROJECT SUMMARY HIV-related stigma and discrimination operate at multiple socioecological levels and are known obstacles to optimal health and HIV outcomes. In Zambia, some boarding school environments can be characterized by a culture of physical, verbal, and sexual abuse strongly linked to stigma …
Sarah E Webster · WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE · 2024 · $74,084 — PROJECT SUMMARY/ABSTRACT Lower respiratory tract infections such as pneumonia claims the lives of approximately 4 million people worldwide each year, making these infections fourth on the list of global causes of death. Streptococcus pneumoniae is the most common cause of pneumonia leading to death …
Tristan Shuman · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $124,813 — Project Summary/Abstract – From Parent Grant Alzheimer's disease (AD) is a form of dementia characterized by memory loss and progressive cognitive impairments. The leading hypotheses over the past decade have assumed that these symptoms are due to accumulation of amyloid-beta (Aβ) and tau proteins t…
Charles Bou-Nader · EMORY UNIVERSITY · 2024 · $249,000 — Project Summary/Abstract The proposed research seeks to elucidate the structural and mechanistic basis of RNA-dependent innate immune antiviral proteins regulation that stop translation to curb viral infection. The proposal employs a synergistic combination of structural biology (X-ray crystallograp…
William Combs · 3DT HOLDINGS, LLC · 2024 · $437,461 — ABSTRACT Heart failure (HF) is a nationwide epidemic with over 6 million afflicted patients and 600,000 new patients diagnosed each year. Many HF patients present with left bundle branch (LBB) block morphology and mechanical dyssynchrony which are strong predictors of cardiovascular mortality. Cardi…
Kevin R. Cleary · MIRA MEDICAL, LLC · 2024 · $306,858 — Project Summary The incidence of pediatric fractures is reported to be in the range of 12 to 36.1 per 1000 per year, with forearm fractures constituting approximately 40% of all long bone fractures. A timely and accurate diagnosis of forearm fractures is crucial to restore function and prevent compl…
Michael-Christopher Keogh · EPICYPHER, INC. · 2024 · $184,692 — PROJECT SUMMARY Gene expression is regulated by the complex molecular cross-talk between DNA methylation (DNAme) and other chromatin features: e.g. histone post-translational modifications (PTMs) and chromatin associated proteins (ChAPs; transcription factors and chromatin remodelers). Significantl…
Dan H. Barouch · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $1,503,450 — The goal of therapeutic vaccination is to increase host immune control of HIV-1 to achieve durable virologic control in the absence of ART, which is defined as a “functional cure”. However, therapeutic vaccine studies in humans have to date been largely unsuccessful. We speculate that this may refle…
Connie Manz · BACKSTOP NEURAL, INC. · 2024 · $485,026 — Project Summary BackStop Neural proposes to demonstrate the feasibility of a novel paddle-type epidural stimulation lead to relieve chronic arm and neck pain. To date, spinal cord stimulation (SCS) has been used primarily to treat chronic back and leg pain, which require placement of electrodes in t…
Yicheng Wang · IMMUNOVA THERAPEUTICS, LLC · 2024 · $1,001,029 — Abstract Breast cancer is a leading cause of cancer-related deaths of women in the United States and worldwide. Immunotherapy is a promising approach, but has not proven successful yet in metastatic breast cancer, particularly in triple-negative breast cancer (TNBC). TNBC is the most aggressive subt…
Donald Davidson · CREATIVE BIOTHERAPEUTICS, LLC · 2024 · $400,000 — PROJECT SUMMARY Brain cancers are the leading cause of disease-related death in children and in adults under the age of 40 years old. Even with aggressive treatments that include maximal surgical resection, stereotactic radiosurgery, whole-brain radiation therapy, chemotherapy, molecularly targeted…
Benjamin Goldman Cooper · ORTHOLEVO, INC. · 2024 · $504,965 — PROJECT SUMMARY/ABSTRACT Shoulder contracture or “arthrofibrosis” is a painful and gradual loss of shoulder motion caused by trauma, surgical procedures, inflammation, prolonged joint immobilization, or for no clear cause (i.e. idiopathically), as is the case in “frozen shoulder”. Shoulder arthrofi…
Alex Sajovic Moreland · XIRETSA INC. · 2024 · $299,995 — PROJECT SUMMARY Antimicrobial resistance (AMR) is an existential threat to global human health, causing ~1.3M deaths and ~50M years of life lost annually. Antibiotics are the cornerstone of modern medicine, and we stand to lose advances in treating myriad diseases if we lose the arms race with AMR. …