Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Dionysios C Watson · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $249,000 — PROJECT SUMMARY: Glioblastoma (GBM) is the most common primary brain tumor and is incurable, invariably recuring after standard therapy with surgery, chemotherapy and radiation. GBM cell heterogeneity allows it to thrive in varying adverse conditions in the tumor microenvironment (TME), including th…
Teryn Allene Holeman · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $40,126 — ABSTRACT Peripheral artery disease (PAD) is the one of the most common causes of morbidity and mortality for adults in the United States. The number of patients needing surgical management for this condition is expected to nearly double over the next 30-years. Patients with symptomatic PAD are refer…
MATTHEW B RETTIG · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · 2024 — Alternative treatment approaches are urgently needed to improve quantity and quality of life of patients with metastatic castration resistant prostate cancer (mCRPC). Immunotherapy in the form of checkpoint inhibition has yielded auspicious results in many cancers, including lung cancer, melanoma, r…
Holly Michelle Crowe · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $185,220 — PROJECT SUMMARY/ABSTRACT Approximately 1 in 3 reproductive aged women and girls suffer from migraine, the most disabling disease of this demographic worldwide. Affective disorders are 2-3 times more common among migraineurs, and migraineurs with psychiatric comorbidity report more functional impair…
Faye Norby · UNIVERSITY OF MINNESOTA · 2024 · $141,154 — PROJECT SUMMARY Sudden cardiac arrest (SCA), a sudden catastrophic loss of the pulse, continues to be a major public health issue. A proportion of SCA events occur in persons engaging in drug use and given that drug overdose deaths are at unprecedented levels in the United States, the epidemiology o…
Prasenjit Dey · ROSWELL PARK CANCER INSTITUTE CORP · 2024 · $58,959 — Project Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease that remains largely incurable. Although the cause for this profound therapeutic resistance is poorly understood, it is however partly blamed on signaling factors present in the tumor microenvironment (TME), which supp…
Sharona E Gordon · UNIVERSITY OF WASHINGTON · 2024 · $199,615 — ABSTRACT Ion channels are integral membrane proteins with gated transmembrane pores that conduct ions down their electrochemical gradients to transduce chemical, mechanical, and optical signals into electrical signals. In this proposal, we leverage a host of innovative tools to decipher allosteric g…
Susana M Salazar Marocho · UNIVERSITY OF MISSISSIPPI MED CTR · 2024 · $310,000 — SUMMARY We aim to combine the laser energy with a novel primer for bonding reversibly to high-strength ceramic crowns. This proposal seeks to investigate the novel primer’s bonding and debonding capabilities to address the destructive and traumatic removal of high-strength all-ceramic crowns using h…
Laura Quinones-Camacho · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $53,549 — PROJECT SUMMARY Anxiety symptoms are one of the most prevalent and earliest forms of psychopathology in childhood and have been linked with lasting effects on socioemotional wellbeing, reduce life satisfaction, and increase chance of more severe psychopathology developing into adolescence and adulth…
Jennifer Elaine Mack · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $404,212 — Project Summary/Abstract People with aphasia often experience challenges conveying their thoughts to unfamiliar communication partners, which is critical for living independently and building new social connections. This line of research has two long-term objectives: to improve unfamiliar communica…
Emily Devericks · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $14,797 — Project Abstract Breast cancer remains the second-leading cause of cancer-related death in the US. Obesity is an established risk factor for several aggressive breast cancer subtypes, and is also associated with increased breast cancer metastasis and mortality. On a mechanistic level, diet-induced o…
Joseph Piven · WASHINGTON UNIVERSITY · 2024 · $687,270 — ABSTRACT (verbatim, original text) The overarching goal of this proposal is to lower the age of detection in autism to early infancy, making presymptomatic (i.e., before the emergence of ASD-specific behavioral features) intervention feasible. Infants with an older autistic sibling have up to a 20% …
Andy SL Tan · UNIVERSITY OF PENNSYLVANIA · 2024 · $175,440 — PROJECT SUMMARY. The parent R01 of this proposed supplement Project SMART (Social Media Anti- Vaping Messages to Reduce ENDS Use Among Sexual and Gender Minority Teens; R01DA054236-01) is to evaluate the effectiveness of an SGM-tailored social media intervention to prevent vaping initiation among SG…
Andrew Mehle · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $51,194 — ABSTRACT FOR PARENT AWARD R01AI164690 Influenza virus is a serious public health threat causing high levels of morbidity and mortality. The annual disease burden from influenza places a significant strain on our healthcare infrastructure and economy. This is despite many efforts to control disease w…
Emma Rachel Lawrence · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $192,507 — Project Summary / Abstract Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality, particularly in LMICs. Home BP monitoring is an emerging strategy to promote frequent monitoring of BPs, however unique challenges exist in LMICs. Given widespread smartphone use i…
Filippo Veglia · WISTAR INSTITUTE · 2024 · $486,185 — Glioblastoma (GBM), the most aggressive and lethal form of brain cancer, is characterized by a profound immunosuppressive microenvironment (TME) that restricts the effects of promising immunotherapies. Therefore, there is a pressing need to develop more effective interventions to overcome this mecha…
Arthur Durazo · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2024 · $191,251 — PROJECT SUMMARY/ABSTRACT This multi-phased, community-engaged R34 proposal was developed with community partners to (1) inform, (2) develop, and (3) pilot test protocol for ECHO (Empowering Our Community & Health Outcomes), a smoking cessation intervention tailored for sexual and/or gender minority …
Rachel Emma Lean · WASHINGTON UNIVERSITY · 2024 · $54,000 — PROJECT SUMMARY/ABSTRACT Deficits in effortful control (EC; top-down control of self-regulation involving inhibitory control and executive attention) represent a major transdiagnostic risk factor for multiple psychiatric disorders in childhood. Dysfunctional parenting is a strong predictor of impair…
Mengfei Liu · YALE UNIVERSITY · 2024 · $75,600 — Project Abstract Alcoholic hepatitis (AH) is characterized by intense liver inflammation and injury in the setting of excess alcohol ingestion. Cytokine and chemokine upregulation leads to immune cell infiltration and drives inflammation in AH. Liver sinusoidal endothelial cells (LSEC) are an import…
THOMAS M WISNIEWSKI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $39,934 — Since its inception in 1990, the Alzheimer's Disease Research Center (ADRC) at New York University Langone Health has facilitated pioneering research to define transitions from normal aging to the subjective cognitive decline (SCD), mild cognitive impairment (MCI), and early dementia stages of AD; a…