Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
CHRISTOPHER J. BAKKENIST · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $69,960 — PARENT GRANT – ABSTRACT (as per original submission) The overarching goal of our laboratory is to determine how DNA damage response inhibitors (DDRi) can be used to potentiate cancer cell killing while concurrently increasing anti-tumor immune responses after radiation therapy (XRT). The DNA Damage …
Anthony Spirito · BROWN UNIVERSITY · 2024 · $141,317 — PROJECT SUMMARY/ABSTRACT The preteen years are a critical period in which to study the development of suicidal thoughts and behavior (STB). During this period, youth experience changes in emotion regulation and develop cognitive capacities that include an emerging understanding of the permanence of …
Xiaobing Yu · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $106,611 — PROJECT SUMMARY Debilitating pain, a hallmark of tissue injury and neuropathy, is an unmet clinical challenge particularly in musculoskeletal diseases, such as heterotopic ossification (HO). HO can occur following orthopedic surgery and traumatic injuries, manifests with pathological bone formation …
Elain Fu · OREGON STATE UNIVERSITY · 2024 · $300,000 — PROJECT SUMMARY (See instructions): To optimize drug dosing, clinicians may order laboratory testing of drug levels in patient blood samples, but the clinical benefit of such testing is limited because testing is slow and infrequent. While field-use measurement systems are a partial solution, a majo…
Mangilal Agarwal · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $300,000 — Cystic fibrosis (CF) is a genetic disorder that negatively affects young people across the globe. Pulmonary exacerbations (PEx), episodes of decreased lung function accompanied by coughing, increased sputum production, and weight loss, are a hallmark of CF lung disease. Besides negative health imp…
Andrea Goldstein-Piekarski · STANFORD UNIVERSITY · 2024 · $98,828 — PROJECT SUMMARY/ABSTRACT BACKGROUND: Several independent lines of evidence suggest that sleep disturbance may directly contribute to the generation and maintenance of neuropsychiatric symptoms (NPS) including anxiety, depression, agitation, irritability, and apathy through fronto-limbic brain networ…
Hokyung Kay Chung · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $159,840 — PROJECT SUMMARY/ABSTRACT Recently, remarkable progress has been made in cancer treatment employing adoptive cell transfer (ACT) of tumor-specific “killer”, CD8+ T cells. Various engineered T cells including chimeric antigen receptor T (CAR-T) cells, have shown great potential as new forms of cancer …
Eric Collisson · FRED HUTCHINSON CANCER CENTER · 2024 · $655,693 — Project Summary/Abstract Summary: Precision cancer medicine’s foundation lies in discovering and exploiting pathways that are essential for cancer cells, but dispensable for cancer cells. While such pathways exist, they are relatively uncommon. Much more often the oncogenic pathways activated in can…
Rebecca L Pearl · UNIVERSITY OF FLORIDA · 2024 · $71,690 — PROJECT SUMMARY/ABSTRACT Stigma adversely affects mental and physical health. Societal devaluation or mistreatment from others can lead to internalization of stigma (i.e., self-stigma) among individuals with marginalized identities or traits. Internalized stigma is robustly associated with impaired…
John D Gordan · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $20,836 — ABSTRACT Of the 6,500 known rare diseases, only about 5% have U.S. Food and Drug Administration-approved treatments. In cancer, rare tumors account for approximately 20% of cancer incidence but often lack established therapeutic regimens. Hence, gaining a molecular understanding of rare tumors is ke…
Monica E Swilley-Martinez · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $41,253 — PROJECT ABSTRACT Formerly incarcerated people are highly vulnerable to drug overdose and suicide deaths upon release from incarceration, yet there are few interventions to address these concerns. Existing programs in the criminal legal system, such as post-release supervision (PRS), can be improved…
Rebecca Ashare · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2024 · $675,089 — PROJECT ABSTRACT Tobacco use has alarmingly high rates among people with HIV (PWH), 43% compared with 15% in the general population. Due to the development of highly effective treatments for HIV and the resulting increased longevity among PWH, this population now loses more life years to smoking tha…
Robert Alan Baiocchi · OHIO STATE UNIVERSITY · 2024 · $249,809 — PROJECT SUMMARY The Ohio State University Comprehensive Cancer Center (OSUCCC) is in its 44th year as an NCI-designated comprehensive cancer center, having received an “exceptional” overall merit descriptor in its last two reviews in 2010 and 2015, and is requesting continued federal support for the…
Cory Justin White · EMORY UNIVERSITY · 2024 · $101,402 — PROJECT SUMMARY/ABSTRACT Defects in lipid metabolism are associated with neurological diseases and mood disorders, but bioenergetics and regulation of lipid metabolism in the brain is not well defined. The brain is the most lipid-rich tissue in mammals other than adipose with a unique profile of li…
Jennifer Nicole Rauch · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $87,281 — Several neurodegenerative diseases, such as Alzheimer’s disease (AD), are characterized by the spread and aggregation of the protein tau. Recently, we identified a cellular receptor, LRP1 (Low-density lipoprotein Receptor-related Protein 1), that regulates the tau spread pathway. Knockdown of LRP1 p…
Ryoji Amamoto · MASSACHUSETTS EYE AND EAR INFIRMARY · 2024 · $135,755 — Project Summary Retinitis Pigmentosa (RP) is an inherited retinal disease afflicting 1 in 4,000 people worldwide. The disease progresses initially by rod photoreceptor degeneration caused by mutations in rod-specific genes, although different mutations in different genes converge upon the same rod d…
WILLIAM George NELSON · JOHNS HOPKINS UNIVERSITY · 2024 · $100,000 — PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-032. Black women have the highest breast cancer mortality rate and shortest overall survival among all racial/ethnic groups of women in the United States. Advers…
Xinyun Cao · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $249,000 — PROJECT SUMMARY With the alarming increase in the incidence of infections caused by antibiotic-resistance bacteria, there is an urgent need to identify new strategies to combat this emerging threat. The development, growth, and survival of all living organisms rely on coordinated gene expression. Ce…
Jennifer Manuzak · TULANE UNIVERSITY OF LOUISIANA · 2024 · $621,740 — PROJECT SUMMARY/ABSTRACT HIV remains one of the world’s most devastating diseases, with more than 38 million people living with HIV (PLWH) and an additional 1.7 million new infections per year. Moreover, in 2019, infection with malaria was reported to have reached 229 million cases worldwide and ca…
Gregory Scherrer · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $705,382 — PROJECT SUMMARY Pain is a multidimensional experience with sensory and affective components. The aversive quality of pain, i.e. its inherent unpleasantness, causes a majority of chronic pain patients’ suffering and often leads to comorbid disorders such as anxiety and depression. Despite their addic…