Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
John A Collins · THOMAS JEFFERSON UNIVERSITY · 2024 · $25,696 — PROJECT SUMMARY/ABSTRACT Age is the number one risk factor for osteoarthritis (OA), however, the mechanisms that drive age-associated joint changes and how these contribute to cartilage damage are not well defined. As OA joint tissues age, it is well established that cartilage-forming stem cells (CS…
Matt Huentelman · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · 2024 · $64,322 — Project Abstract The role of microglia in the C9orf72 (C9) amyotrophic lateral sclerosis (ALS)/ frontotemporal dementia (FTD) disease spectrum remains poorly understood. Early investigations found that microglia activation was significantly higher in ALS with dementia and impaired executive function…
Guy M McKhann · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $76,070 — Program Director/Principal Investigator (Last, First, Middle): Teich, Andrew, Franklin Project Summary The overall goal of this grant is to use surgically removed brain tissue and CSF from elderly patients presenting for hydrocephalus surgery to characterize the effects of early co-morbid Alzheimer’…
Joseph Antony Cafazzo · YALE UNIVERSITY · 2024 · $235,580 — Project Summary In Uganda, heart failure presents significant challenges due to limited resources and high prevalence. This diversity supplement proposes an implementation adaptation study that aims to enhance HF diagnosis and treatment through two main strategies. First, leveraging the parent R01's…
Mark J Mandel · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $56,926 — PARENT AWARD R35GM148385 PROJECT SUMMARY The objective of my laboratory is to characterize how molecular communication between bacteria and their animal hosts leads to specific and reproducible colonization. To accomplish this goal, the laboratory studies the Vibrio fischeri-squid system, in which t…
Jane Hoyt Buckner · BENAROYA RESEARCH INST AT VIRGINIA MASON · 2024 · $365,178 — SUMMARY This is a request for an Administrative Supplement for the Immune Drivers of Autoimmune Disease (IDAD) project U01 AI176320 “T cells promoting transitions toward autoimmunity”. The proposed studies for the Administrative Supplement are within the scope of the active parent grant, focused on …
Jason J Hassenstab · WASHINGTON UNIVERSITY · 2024 · $208,883 — PROJECT SUMMARY The Down Syndrome – Ambulatory Research in Cognition (DS-ARC) study will develop and validate a smartphone-based digital cognitive assessment designed specifically for participants at risk for Down syndrome-associated Alzheimer’s disease (DS-AD). We will partner with sites in London,…
SANFORD D. MARKOWITZ · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $94,538 — Abstract. Prostaglandin E2 (PGE2) regulates tissue growth and repair in multiple organs. A conserved mechanism of synthesis and degradation modulates PGE2 levels in response to trauma, inflammation and disease. In particular, the enzyme 15-prostaglandin dehydrogenase (15-PGDH) is the main PGE2-degra…
MATTHEW H SAMORE · VA SALT LAKE CITY HEALTHCARE SYSTEM · 2024 — The Informatics, Decision-Enhancement, and Analytic Sciences (IDEAS) Center of Innovation creates a dynamic environment within the Veterans Health Administration (VHA) where informatics is tightly integrated with health services research and other disciplines. Biomedical informatics is a unifying th…
Chad V Pecot · ENFUEGO THERAPEUTICS INC. · 2024 · $919,020 — Project Summary The proto-oncogene KRAS is one of the most critical genes in cancer, yet, as a drug target, it has proven to be among the most elusive. A remarkable 30% of lung adenocarcinomas, 45% of colon, and 98% of pancreatic cancers are driven by KRAS mutations. These cancers account for the t…
Jeremy David Keenan · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $695,692 — PROJECT SUMMARY/ABSTRACT Most glaucoma in the United States goes undetected, and hence, untreated until late stages of disease. Open angle glaucoma is a progressive disease that is asymptomatic in its early to moderate stages and thus may be amenable to screening. Eye disease screening of the gener…
Arul Veerappan · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $160,804 — PROJECT SUMMARY. This K01 grant proposal will investigate the early vascular injury and end organ dysfunction in World Trade Center (WTC)-Particulate Matter (WTC-PM) exposed and affected by gastroesophageal reflux disease (GERD). PM is the main component of WTC dust, and the exposure of WTC- PM incl…
Amir Sapkota · UNIV OF MARYLAND, COLLEGE PARK · 2024 · $372,713 — PROJECT ABSTRACT Ongoing climate change is leading to an increase in the frequency and intensity of both extreme heat events (EHEs) and wildfires, a significant source of air pollution including PM2.5 (particulate matter with aerodynamic diameter less than 2.5 microns). This trend is projected to co…
Erum Aftab Hartung · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $400,000 — PROJECT SUMMARY / ABSTRACT Autosomal recessive polycystic kidney disease (ARPKD) is a rare disease, affecting ~1,500 children and young adults in the U.S. In severely affected patients, ARPKD can present in the neonatal period with massively enlarged kidneys and pulmonary hypoplasia, but the clinica…
Richard L Neitzel · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $1,800,000 — Research & Related Other Project Information Overall Overall. 7 Project Summary/Abstract Since inception in 1982, the University of Michigan ERC, the Center for Occupational Health and Safety Engineering, has provided comprehensive graduate-level educational programs to aspiring practitioners and re…
Michael J DiStefano · UNIVERSITY OF COLORADO DENVER · 2024 · $99,999 — PROJECT SUMMARY Over 30 million Americans have type 1 diabetes (T1D) or type 2 diabetes (T2D), a disease with significant effects on morbidity and mortality1 that disproportionately affects non-White adults and low-income populations.2,3 For diabetes patients, tight glycemic control can reduce the r…
Anna Nolan · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $599,258 — SUMMARY Biomarkers of metabolic syndrome(MetSyn) and vascular disease expressed soon after World Trade Center (WTC) particulate matter (PM) exposure predict development of WTC-Lung Injury (WTC-LI). However, the identification of biosignatures and molecular determinants of WTC-PM related disease are …
Abigail Williams - Butler · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $51,662 — Project Summary Youth in foster care have higher healthcare utilization and costs than the general population. Healthcare systems, state departments of Medicaid, and other organizations often shoulder this high cost without evidence of improved health outcomes for youth in foster care. Black youth i…
Matthew Alcusky · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $400,000 — PROJECT SUMMARY Nearly 1.25 million Americans aged 65 years and older receive hospice services annually, with hospice medications paid for by two Medicare programs: the Medicare Part A Hospice Benefit and the Medicare Part D prescription drug benefit. A 2012 Office of the Inspector General (OIG) aud…
MARY A STAAT · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $1,234,285 — PROJECT SUMMARY ABSTRACT- MANDATORY CORE The purpose for Mandatory Core Component A is to support an Enhanced Surveillance Network of US pediatric institutions to develop and implement standard research protocols to conduct prospective active population-based surveillance in defined inpatient and em…