Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
RICHARD K ZIMMERMAN · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $1,900,000 — Abstract – Component A We are applying for RFA components A and D. This abstract refers to Component A. Influenza/pneumonia comprise the 9th and COVID-19 the 3rd leading cause of death in the U.S., with the pandemic entering its 3rd year. Vaccine effectiveness (VE) estimates vary by host factors, v…
Connie L Jiang · HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE · 2024 · $350,000 — Title: Nitrosamines Forum for Advancing Critical Translational Science (NA FACTS) FOA Title & Number: Identification and Evaluation of Possible Approaches to Addressing Nitrosamine Impurities in Drugs (U01), RFA-FD-24-020 Project Summary 1 The Health and Environmental Sciences Institute (HESI) will…
Jennifer E Schuster · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · 2024 · $1,234,285 — Component A: Project Summary The Kansas City-New Vaccine Surveillance Network (KC-NVSN) program has been performing population-based, laboratory-confirmed, active surveillance of acute gastroenteritis (AGE) illness and acute respiratory illness (ARI) in children seeking care at Children’s Mercy (CM)…
Alex D Federman · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $250,816 — Asthma is one of the most common physical health conditions in World Trade Center (WTC) responders, affecting approximately one third of individuals. Moreover, most WTC responders with asthma continue to report substantial symptoms, experience poor disease control, and have high acute resource utili…
Christina D Smith · KANSAS STATE DEPT OF HLTH AND ENVIRONMNT · 2024 · $175,000 — Kansas PRAMS: Component A (Core Surveillance) Project Summary/Abstract The Kansas Pregnancy Risk Assessment Monitoring System (PRAMS) is a collaborative project with the Centers for Disease Control and Prevention (CDC) to establish a state-specific, population-based, surveillance system of maternal …
Richard Ryan Darby · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $159,438 — ABSTRACT: Antisocial behavior is common in patients with frontotemporal dementia (FTD). These behaviors result in significant morbidity and can lead to crimes in extreme cases. Yet despite being one of the most challenging and problematic symptoms to manage clinically, the mechanisms leading to anti…
Dwight J Klemm · VA EASTERN COLORADO HEALTH CARE SYSTEM · 2024 — Menopause is a normal occurrence in all women and a gradual process that begins in the 5th decade of life. Menopause is characterized by the loss of ovarian hormones that ultimately leads to a number of comorbidities including weight gain, redistribution of fat from hips, waist and buttocks to the a…
Ellen I Hartig · TUFTS UNIVERSITY BOSTON · 2024 · $44,724 — PROJECT SUMMARY/ABSTRACT Our ability to hear relies on a small population of specialized sensory ‘hair’ cells in the inner ear that cannot regenerate upon damage. Variants of over 100 human genes have been associated with deafness, many of which alter the structure of the sensory organelle in hair c…
Charles Scott Craik · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $568,644 — Abstract. A devastating class of untreatable, neurodegenerative disorders, which includes progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and Alzheimer’s disease (AD), are associated with accumulation of neurofibrillary tangles (NFTs) in the brain. These aggregates are primaril…
Tyler J. Curiel · GEORGE WASHINGTON UNIVERSITY · 2024 · $675,405 — ABSTRACT Programmed death-ligand 1 (PD-L1) and its receptor, programmed cell death protein 1 (PD-1), modulate anti-tumor immunity and are major targets of current checkpoint blockade immunotherapies. However, clinical trials of αPD-L1/αPD-1 antibodies in breast cancer to date have demonstrated only…
Nadine M. Melhem · WASHINGTON UNIVERSITY · 2024 · $645,922 — Early life stress is associated with increased risk for psychiatric disorders that is long lasting into adulthood. Much of the research has focused on middle childhood and adolescence, however, there is mounting evidence that stressful life experiences occurring in early childhood set the foundation…
Alison Kell · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2024 · $237,136 — Mammalian hantaviruses (order Bunyavirales, genus Orthohantavirus) are zoonotic RNA viruses that cause severe vascular inflammatory disease in humans, with case-fatality rates of up to 40%. These negative-sense, tri-segmented viruses are maintained, persistently and asymptomatically, within wild rod…
Holger Willenbring · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,211,250 — PROJECT SUMMARY/ABSTRACT – UCSF LIVER CENTER The Liver Center at the University of California San Francisco (UCSF) is an interdisciplinary consortium of 56 basic and clinical scientists dedicated to understanding liver biology and contributing new knowledge about the pathophysiology and treatment of…
Mara Burns · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $45,863 — Project Summary / Abstract: Astrocytes are known to be dysfunctional in Huntington’s disease (HD); however, further research is needed to understand how these star-like cells develop in the context of HD. HD is a devastating, progressive, genetic neurodegenerative disease, and recent work suggests m…
Don Brad Gammon · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $205,000 — Project Summary Bats are important reservoirs for diverse viral pathogens affecting humans. However, we have a poor understanding of the key bat innate immunity factors that restrict virus replication. Functional assays that can identify bat factors that are truly relevant to…
Chengyi Tu · STANFORD UNIVERSITY · 2024 · $151,637 — Tachycardia, or abnormally fast heart rate, is an important risk factor for cardiovascular morbidity and mortality. Prolonged tachycardia is known to induce cardiomyopathy in patients who have no prior structural heart diseases. Moreover, transient tachycardia, frequently observed in heart failure p…
ROY A. JENSEN · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $2,808,765 — OVERALL: ABSTRACT The University of Kansas Cancer Center (KUCC) is a matrix consortium cancer center that includes: The University of Kansas Medical Center (KUMC), the University of Kansas in Lawrence (KU-L) and via consortium agreement, the Stowers Institute for Medical Research (Stowers) and Child…
Dorothy A Sipkins · DUKE UNIVERSITY · 2024 · $494,502 — Leptomeningeal (LM) metastases occur in a wide variety of hematologic and solid malignancies, including leukemia, breast cancer (BC), and lung cancer. When LM metastases arise, they are almost always rapidly fatal, causing severe neurologic symptoms and death within weeks to months. The molecular me…
Nathan H. Roy · UPSTATE MEDICAL UNIVERSITY · 2024 · $407,500 — Project Summary/Abstract Leukocyte migration out of the vasculature into peripheral tissue is crucial for their role in fighting pathogens, promoting tissue repair, and attacking solid tumors. This process is a key control point in the inflammatory response and relies heavily on signaling events dow…
Daniel J. Hayes · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $45,690 — Project Summary The purpose of this program is to educate upper-division biomedical engineering undergraduate students in the area of biomedical device design and development. The development pathway typically includes discovery and ideation, invention and prototyping, pre-clinical and clinical test…