Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Erik D Hanson · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $513,784 — ABSTRACT Among young adults (18-24 years), a concerning 10-20% develop advanced but asymptomatic atherosclerotic lesions, yet cardiometabolic disease (CMD) prevention is understudied. In the U.S. two-thirds of young adults attend college, during which they adopt poor lifestyle behaviors that contrib…
Hamed Khalili · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $531,975 — PROJECT SUMMARY/ABSTRACT Microscopic colitis (MC) is a chronic inflammatory disorder of the large intestine with a rising global incidence. MC primarily affects older adults, in whom it accounts for a significant proportion of cases of chronic diarrhea and fecal incontinence. The growing burden of t…
Omar Abdel-Wahab · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $2,256,925 — OVERALL ABSTRACT Despite recent advances in the treatment of acute myeloid leukemia (AML), the majority of AML patients relapse following treatment and the overall five-year survival rate for adults with AML remains 25-29%. Thus, an urgent need to improve therapy for AML patients remains. The MSK SP…
XUE-RU WU · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $207,000 — This proposal is submitted in response to PAR-23-119: “Catalytic Tool and Technology Development in Kidney, Urologic, and Hematologic Diseases (R21 Clinical Trial Not Allowed)”. The main goal of our application is to test the feasibility and define the strategies, reagents, parameters and methodolog…
GEUNYOUNG YOON · UNIVERSITY OF HOUSTON · 2024 · $436,771 — Abstract Myopia (nearsightedness) is one of the foremost causes of visual impairment worldwide, with severe myopia being linked to several serious eye diseases that can result in permanent blindness. The prevalence of myopia has been increasing and is estimated to affect 50% of the world’s populatio…
Ronald K. Elswick · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $559,138 — PROJECT SUMMARY Approximately 90,000 adolescents and young adults (AYAs) are diagnosed with cancer yearly in the United States. AYAs with cancer experience multiple co-occurring and related symptoms from their disease and treatment that adversely affect their day-to-day lives and are difficult to se…
Anders Fridberger · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $575,351 — Project Summary A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti tune the sound induced vibration of the organ of Corti. A process known as cochlear amplification (CA), now the subject of intense work around the world, has critical components not…
Julie Flom · YALE UNIVERSITY · 2024 · $194,911 — PROJECT SUMMARY/ABSTRACT Peanut allergy affects one in fifty children in the US. There is no cure, and while progress is being made in treatment, the standard of care is peanut avoidance and ready access to injectable epinephrine which can adversely impact quality of life. Based on solid evidence in…
Won Suk Jahng · STANFORD UNIVERSITY · 2024 · $149,948 — Project summary Radiation therapy is an important component of cancer treatments, yet its usage has been hampered due to side effects to normal tissue. The current K99/R00 project seeks to investigate the molecular landscape of radiation induced coronary heart disease (RICHD), a leading cause of mor…
Elizabeth Anne Middleton · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $166,525 — PROJECT SUMMARY/ABSTRACT This is an application for a K08 award for Dr. Elizabeth Middleton, a pulmonary and critical care physician at the University of Utah. Dr. Middleton is establishing herself as a young investigator in translational research of biological mechanisms driving the pathophysiology…
Claudia Michele Toledo-Corral · CALIFORNIA STATE UNIVERSITY NORTHRIDGE · 2024 · $178,667 — PROJECT SUMMARY It is estimated that by 2050, Latino/a/x will compose over half of the California population, highlighting the critical priority for understanding cardiometabolic health risk in this population. Latinx have a 50% lifetime risk of developing type 2 diabetes and other chronic diseases,…
Peggi M Angel · UNIVERSITY OF FLORIDA · 2024 · $756,289 — Abstract: Alzheimer’s disease (AD) is a devastating diagnosis and there is a critical need to understand the fundamental molecular pathogenesis of AD to design effective therapies. In addition to the well-known AD pathologies, perturbed glucose metabolism is also a clinical feature of AD. Glycogen a…
Reinhard Hinterleitner · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $66,992 — Project Summary Enteric helminth infections remain a significant global health problem. Although infections by these parasites are generally not fatal, they are associated with high rates of morbidity, with chronic infection often leading to anemia and malnourishment. Infections are strongly associa…
Robert F Foronjy · SUNY DOWNSTATE MEDICAL CENTER · 2024 · $708,757 — Summary: Both retrospective and longitudinal cohort analyses strongly associate HIV infection with the premature initiation and progression of chronic obstructive pulmonary disease (COPD). Improving long-term pulmonary outcomes and longevity in people living with HIV (PLWH) will require a better und…
Deliang Guo · OHIO STATE UNIVERSITY · 2024 · $418,800 — ABSTRACT Glioblastoma (GBM) is the most common primary brain tumor and one of the most lethal of all cancers. The main challenge in treating GBM is the quickly developing resistance to all kinds of treatments by tumor cells. Whereas our partial understanding of GBM biology is a major roadblock to el…
BRUNO CALABRETTA · THOMAS JEFFERSON UNIVERSITY · 2024 · $599,770 — Abstract Philadelphia-positive acute lymhoblastic leukemia (Ph+ ALL) and Ph1-like B-ALL account for most cases of “high-risk” adult B-ALL. Current therapies with tyrosine kinase inhibitors (TKIs) have improved the outcome of Ph+ ALL, but resistance to TKIs develops rapidly in most patients. Ph1-like…
ANUP KUMER KUNDU · XAVIER UNIVERSITY OF LOUISIANA · 2024 · $112,500 — ABSTRACT The development of multidrug resistance (MDR) in cancer cells is of grave concern, limiting the efficacy of anticancer agents and, hence, the failure of breast cancer therapy. Clinical research and application revealed that in spite of its potential anticancer effects, doxorubicin is highly…
JING ZHANG · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $394,000 — PROJECT SUMMARY In eukaryotes, transcriptional regulation is essential to maintaining cell identity, responding to intra- and extra-cellular signals, and coordinating gene activities, whereas its dysregulation can cause a broad range of disorders. Previous methods mainly used averaged genomic signa…
Igor Astsaturov · RESEARCH INST OF FOX CHASE CAN CTR · 2024 · $208,738 — PROJECT SUMMARY/ABSTRACT This proposal will investigate a novel small-molecule strategy as a means to activate necroptosis, overcome the immunosuppressive tumor microenvironment (TME) and rekindle immune checkpoint blockade (ICB) responsiveness of human solid tumors. Our recent work with influenza v…
Taha A Jan · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $188,296 — PROJECT SUMMARY (ABSTRACT) Sensorineural hearing loss and vestibular dysfunction are most common sensory disorders affecting millions worldwide 1–3. Auditory and vestibular functions require mechanosensitive hair cells, with hair cell loss leading to permanent hearing loss and disabling vestibular …