Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
GWEN V CHILDS · UNIV OF ARKANSAS FOR MED SCIS · 2024 · $549,786 — SUMMARY The prevalence of extreme obesity in adults is increasing precipitously and today more than one-third (39.8%) of adults are obese. Furthermore, the obese condition is characterized by responses and hormone levels that encourage the accumulation of more fat. Obese individuals are resistant to…
Ning Wang · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $323,319 — PROJECT SUMMARY Poor sperm quantity and quality are major causes of male infertility, affecting ~7% of men worldwide. Male fertility depends on the conversion of diploid germ cells (spermatogonia) into haploid spermatozoa (sperm). Meiotic initiation, a defining step in this process, revolves around …
Mark Hedglin · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · 2024 · $394,265 — Project Summary/Abstract The overarching goal of my research program is to understand how the human genome is faithfully replicated when it is constantly damaged by covalent modifications that can alter its coding properties. A focus is on translesion DNA synthesis (TLS), the predominant DNA damage…
Amit Joshi · UNIVERSITY OF TENNESSEE KNOXVILLE · 2024 · $377,002 — PROJECT SUMMARY Intracellular membrane-bound organelles are a hallmark of all eukaryotic cells. Understanding how cells generate different organelles remains one of the central problems in cell biology. Some organelles, like the endoplasmic reticulum (ER) and mitochondria, are self-generating wherea…
Zsuzsanna Kinga Zsengeller · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $262,808 — PROJECT SUMMARY: Our lab in collaboration with Akkadian Therapeutics, Inc. (AKTX), have demonstrated the beneficial effects of the novel catalytic radical scavenger and nitric oxide donor/vasodilator, AKT-1005, in established in vitro and in vivo models of preeclampsia. However, the development of A…
Christine B. Ambrosone · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $989,275 — Abstract Asian American women experience more favorable cancer survival than other US racial/ethnic groups, even after accounting for known prognostic indicators. Breast cancer, which follows this pattern, is a useful model for understanding factors contributing to this intriguing survival advantage…
Jeffrey Hsu-Min Chuang · JACKSON LABORATORY · 2024 · $103,689 — PROJECT SUMMARY / ABSTRACT The long-term goal of the proposed program is to establish a summer undergraduate research fellowship in the molecular biology and genomics of human cancer at The Jackson Laboratory for Genomic Medicine (JAX-GM) in Farmington, CT that will support the need for enhanced edu…
Sydney X Lu · STANFORD UNIVERSITY · 2024 · $241,634 — PROJECT SUMMARY/ABSTRACT Research: RNA binding proteins (RBPs) regulate diverse cellular processes including transcription, translation, and regulation of gene expression, and are frequently dysregulated in cancers. Through an unbiased genetic screen aimed at identifying cancer-specific RBP dependen…
ANTHONY G LETAI · DANA-FARBER CANCER INST · 2024 · $1,007,191 — Summary I am an oncologist and cancer biologist supervising a laboratory focused on identifying therapies that selectively induce apoptosis in cancer cells. My initial contributions to the apoptosis field came with separating certain pro-death BCL-2 family BH3-only proteins into “sensitizers” and “a…
Prasad G. Iyer · MAYO CLINIC ROCHESTER · 2024 · $444,566 — PROJECT SUMMARY/ABSTRACT Esophageal adenocarcinoma (EAC) is a lethal cancer with poor outcomes (5 year survival <20%), when diagnosed after the onset of symptoms, but survival is excellent when diagnosed early. Intestinal metaplasia, or Barrett’s esophagus (BE), is the only known precursor of EAC, a…
Megan J. Huchko · DUKE UNIVERSITY · 2024 · $180,639 — ABSTRACT Women living with HIV (WLWH) are at increased biologic risk for infection with human papillomavirus (HPV) and development of pre-invasive and invasive cervical cancer. The World Health Organization has recently called for HIV-programs to bolster their efforts to prevent cervical cancer thro…
Sean M O'Brien · NORTH CAROLINA STATE UNIVERSITY RALEIGH · 2024 · $294,454 — PROJECT SUMMARY/ABSTRACT This application proposes renewal of an integrated program for predoctoral training in biostatistics, focused on preparing trainees for careers in cardiovascular disease research. The escalating demand for skilled biostatisticians equipped to address ongoing and emerging cha…
Barbara Hirschman Chaiyachati · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $181,186 — Project Summary/Abstract This career development award details a 5-year training plan to facilitate the transition of Dr. Barbara H. Chaiyachati to an independent career as a physician-scientist studying predictors of mental and physical health of children after trauma with an objective to identify …
Alexei Mansfield Bygrave · TUFTS UNIVERSITY BOSTON · 2024 · $241,578 — PROJECT SUMMARY Dysfunction of glutamatergic synapses in inhibitory interneurons (INs) is increasingly being linked to psychiatric diseases and neurological disorders. However, our understanding of the molecular mechanisms distinguishing glutamatergic synapse function in INs from those in excitatory…
Shelley A. Johns · INDIANA UNIVERSITY INDIANAPOLIS · 2024 · $617,829 — PROJECT SUMMARY / ABSTRACT Following treatment for early-stage cancer, most survivors fear the possibility of a recurrence. While mild and intermittent for many, these fears become clinically significant for approximately 40% of survivors, adversely affecting mood, coping, and quality of life while …
Xiaolei Su · YALE UNIVERSITY · 2024 · $418,750 — Project Summary The overall goal of this project is to understand how the spatial organization of signaling molecules on the cell membrane regulates signal transduction. Extracellular stimuli are transduced across the plasma membrane, processed, and amplified along the inner leaflet of the lipid bil…
Roland Horst Friedel · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $421,025 — The malignant brain tumor glioblastoma (GBM) is highly infiltrative. Migrating GBM cells are exposed to biomechanical forces during tumor invasion, however, little is understood of the mechanosensitive pathways that enable GBM cells to gain invasiveness. Here, we postulate that Plexin guidance recep…
Robert F. Schwabe · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $481,473 — Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide, causing over 700,000 deaths annually. In the US, HCC rates have tripled in the last three decades. The rise in obesity, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is incre…
Diane Joss · CAMBRIDGE HEALTH ALLIANCE · 2024 · $82,000 — Project Summary Critical self-judgment is a common phenomenon underlying a wide range of psychological disorders. The proposed project aims to investigate the neural mechanism of critical self-judgment by analyzing fMRI and questionnaire data from a total of 203 subjects collected from 5 previous pr…
Ricardo C Aguiar · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · 2024 — TET DNA hydroxylases are alpha-ketoglutarate (αKG)-dependent enzymes that catalyze the oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), thus promoting DNA demethylation. Mapping of 5hmC marks at single base resolution demonstrated that the main role of TET enzymes is to maintain gene enhancers hy…