Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Giulio Maria Pasinetti · JAMES J PETERS VA MEDICAL CENTER · 2024 — Project Summary/Abstract At least 30% of Afghanistan and Iraq veterans are affected by Major Depressive Disorder (MDD) and 20% are affected by post-traumatic stress disorder (PTSD) and other stress-related mood disorders. Currently existing pharmacological treatments elicit temporary remission in <5…
Issam Ben-Sahra · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $320,000 — SUMMARY The mechanistic target of rapamycin complex 1 (mTORC1) senses and integrates diverse environmental signals to control energy and nutrient-consuming biosynthetic processes, such as protein, lipid, and nucleotide synthesis. mTORC1 stimulates anabolic cell growth through posttranslational and t…
Rodney D Newberry · WASHINGTON UNIVERSITY · 2024 · $436,629 — The body's largest collection of immune cells underlies the single layer epithelium lining the gastrointestinal (GI) tract and monitors the luminal contents, which includes trillions of microbes, their products, and substances from the diet. The basal tone of the healthy gut immune system is tolerog…
MONICA G. RIVERA-MINDT · FORDHAM UNIVERSITY · 2024 · $822,437 — HIV remains a major public health problem, particularly for the Latina/o population. US-dwelling Latinas/os are at increased risk for HIV-infection compared to non-Hispanic whites and suffer a disproportionate burden of HIV-associated neurocognitive disorder (HAND) which may be amplified with age. H…
David A Morilak · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · 2024 — Current pharmacological treatments for PTSD and comorbid depression are inadequate. These stress- related psychiatric illnesses of high significance and impact to the veteran population, and finding more effective treatments would satisfy a tremendous gap in veterans’ health care. Evidence-based beh…
Waheeda Samady · LURIE CHILDREN'S HOSPITAL OF CHICAGO · 2024 · $190,080 — PROJECT SUMMARY Peanut allergy (PA) is the most common food allergy in the US; it is also one of the least frequently outgrown and the leading cause of fatal food-allergic reactions. The landmark Learning Early About Peanut study found that the ingestion of peanut products in infancy can decrease PA…
Donald YM Leung · NATIONAL JEWISH HEALTH · 2024 · $4,354,533 — PROJECT SUMMARY/ABSTRACT Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. AD is associated with defective skin barrier function, microbial dysbiosis, as well as various cutaneous immune abnormalities including type 2 inflammation and decreased cu…
Preethi Ganapathy · UPSTATE MEDICAL UNIVERSITY · 2024 · $251,295 — PROJECT SUMMARY/ABSTRACT Neuronal damage in glaucoma occurs following pathologic mechanical strains and fibrosis of the optic nerve head (ONH). Despite an abundance of evidence implicating mechanical strain and matrix fibrosis in glaucomatous damage, it is not known to what extent and how ONH cells …
Robert J DeVita · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $383,980 — SUMMARY Therapies to treat Crohn's disease (CD) and ulcerative colitis (UC), the types of inflammatory bowel disease (IBD) characterized by severe chronic inflammation of the gastrointestinal tract, have greatly improved over the past three decades; yet, a large proportion of IBD patients fail to ac…
Charles W. Flexner · JOHNS HOPKINS UNIVERSITY · 2024 · $796,698 — The Long-Acting/Extended Release Antiretroviral Research Resource Program (LEAP) provides broadly based scientific support to accelerate the development of novel drugs, formulations, and technologies for the treatment and prevention of HIV and related epidemics. The LEAP Process to facilitate drug a…
Joyce Blossom Kang · HARVARD MEDICAL SCHOOL · 2024 · $51,226 — Project Summary: Autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, are debilitating and highly prevalent chronic conditions that result from pathogenic inflammatory responses. The major histocompatibility (MHC) region on chromosome 6, which contains the human leuko…
Phong Thanh Nguyen · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $125,000 — Project Summary Cells use post-translational modifications (PTM) to modulate protein function by conjugating and deconjugating modifiers to protein targets. Imbalance in these reactions leads to human disease. Conjugation of ubiquitin-fold modifier 1 (UFM1) to protein targets (UFMylation) has been l…
Elliott Royal Weinstein · UNIVERSITY OF MIAMI CORAL GABLES · 2024 · $50,000 — Project Summary Overview. This study addresses gaps in HIV and behavioral health research among older sexual minority men (OSMM). Specifically, this project assesses the relative severity and impact of contextually relevant age-related syndemic factors (age-related discrimination, internalized ageis…
Andrew Kerkhoff · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $199,800 — PROJECT SUMMARY/ABSTRACT Three million global tuberculosis (TB) cases remain undiagnosed each year, which is a key factor underpinning why TB is the leading cause of death among people living with HIV (PWH) and the leading infectious cause of death worldwide. While community-wide screening for TB in…
RAINA N. FICHOROVA · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $733,193 — Miscarriage - defined as pregnancy loss prior to 20 weeks of gestation - is the most common pregnancy complication, affecting 10-20% of clinically recognized pregnancies. While advances have been made in noninvasive prenatal diagnosis of chromosomal abnormalities leading to pregnancy loss, the patho…
Matt Vassar · OSU CENTER FOR HEALTH SCIENCES · 2024 · $40,192 — Project Summary/Abstract The objective of this proposal is to establish a short-term summer research program for American Indian medical students to work jointly with mentors at 10 National Institute on Alcohol Abuse and Alcoholism-funded alcohol research centers and Oklahoma State University Center…
ALLEN D EVERETT · JOHNS HOPKINS UNIVERSITY · 2024 · $654,440 — Fifty percent of neonatal encephalopathy cases result from hypoxic-ischemic encephalopathy (HIE). Therapeutic hypothermia (TH), the only approved therapy remains state of the art care for HIE, despite only a 30% reduction in death and significant disability. Our limited ability to accurately track T…
Katy Patras · BAYLOR COLLEGE OF MEDICINE · 2024 · $198,614 — PROJECT SUMMARY Infections during pregnancy or the neonatal period account for more than two million deaths globally each year. Frequently, the pathogens causing these infections begin as residents of the maternal vaginal microbiota and ascend to the uterus during pregnancy. One such pathogen, group…
Shehzad Basaria · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $186,802 — PROJECT SUMMARY Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application for a K24 Mid-Career Development award to provide protected time to men…
Cristopher M Niell · UNIVERSITY OF OREGON · 2024 · $258,691 — Project Summary The proposed research education program, Navigating Educational Trajectories in Neuroscience (NET Neuro), is an innovative cohort-model designed to accelerate pre- and postdoctoral trainees’ success by fostering community among peers and faculty at critical transition periods in thei…