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Principal Investigator: Shehzad Basaria
Organization: BRIGHAM AND WOMEN'S HOSPITAL
Fiscal Year: 2024
Award: $186,802
Funding agency: National Institute on Aging
PROJECT SUMMARY
Shehzad Basaria, MD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology,
Diabetes, & Metabolism at Brigham and Women's Hospital, Harvard Medical School, submits this application
for a K24 Mid-Career Development award to provide protected time to mentor trainees in Patient-Oriented
Research (POR) in Endocrine aspects of Gero-Oncology. Dr. Basaria is one of the few endocrinologists
worldwide specializing in endocrine and cardio-metabolic disorders in older men with cancer and androgen
deficiency. He will pursue additional training to hone his mentoring skills in order to build on his established
record of mentorship and foster the research careers of early investigators.
Candidate: Dr. Basaria is a highly productive clinical researcher in the field of Endocrinology, Aging and
Cancer. Since 2003, he has been continuously NIH-funded to investigate: i) endocrine and cardio-metabolic
complications of androgen deprivation therapy (ADT) in men with prostate cancer (PCa), ii) benefits and risks
of androgen replacement in older men, and iii) endocrinology of aging. He has conducted his investigations
using NIH-supported infrastructure, including RO1s and R21 grants, data from the Baltimore Longitudinal
Study of Aging (BLSA), the InChianti Study, and the Boston Pepper Center for Function-Promoting Therapies.
With his uncommon skill set and strong POR program in Endocrinology and Gero-Oncology, he has been a
sought-after collaborator and mentor at Brigham/Harvard and at national and international institutions.
Mentoring Plan/Environment: This application will leverage the extensive training resources at
Brigham/Harvard, including the Center for Clinical Investigation, the Brigham Research Institute for Clinical and
Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparalleled
resources of the Boston Pepper Center and other funded studies to serve as a platform for POR trainees at
multiple levels.
Research Plan: The novel research supported by this K24 award will make significant contributions to the
1A) The
impact of ADT-induced profound hypogonadism and the resulting decline in muscle mass on physical function,
1B) The impact of ADT on fat infiltration of skeletal muscles and the association of this deterioration in muscle
quality on physical function, and 2) The mechanisms by which testosterone replacement improves Cancer-
Related Fatigue in older men with cancer.
understanding of the impact of androgen deficiency in older men with cancer in three major areas:
These novel aims will build on the ongoing work in Dr. Basaria's
current R01s, explore new hypotheses, and expand opportunities for trainees.
Terms: <65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Address><Age><Aged 65 and Over><Aging><American><Androgenic Agents><Androgenic Compounds><Androgens><Area><Award><Baltimore><Benefits and Risks><Body Tissues><Boston><Cancer Burden><Cancers><Capsicum><Cardiometabolic Disease><Cardiometabolic Disorder><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Castration><Clinical><Clinical Research><Clinical Study><Clinical Trials><Colorectal Cancer><Data><Deposit><Deposition><Deterioration><Diabetes Mellitus><Diagnosis><Disease><Disorder><Dysfunction><Endocrine><Endocrine Diseases><Endocrine Diseases and Manifestations><Endocrine System Diseases><Endocrinologist><Endocrinology><Enrollment><Environment><Erythropoiesis><Faculty><Fatigue><Fats><Fatty Liver><Fatty acid glycerol esters><Fostering><Functional disorder><Funding><General Population><General Public><Geriatrics><Goals><Grant><Health><High Prevalence><Hospitals><Hypogonadism><Incidence><Infiltration><Inflammation><Inflammatory><Infrastructure><Institution><Insulin Resistance><Intermediary Metabolism><International><Investigation><Investigators><K-Awards><K-Series Research Career Programs><K24 Award><Lack of Energy><Leanness><Liver Steatosis><Longitudinal Studies><Lower Extremity><Lower Limb><MR Spectroscopy><Magnetic Resonance Spectroscopy><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant Tumor of the Prostate><Malignant neoplasm of lung><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Medical><Medicine><Membrum inferius><Membrum superius><Mentors><Mentorship><Metabolic><Metabolic Processes><Metabolic syndrome><Metabolism><Metabolism and Endocrinology><Metastatic Prostate Cancer><Mid-Career Clinical Scientist Award (K24)><Morbidity><Morbidity - disease rate><Muscle><Muscle Tissue><NIH><National Cancer Burden><National Institutes of Health><Oncology><Oncology Cancer><Participant><Physical Function><Physical Performance><Physiopathology><Productivity><Prostate><Prostate CA><Prostate Cancer><Prostate Carcinoma Metastatic><Prostate Gland><Prostate malignancy><Prostatic Cancer><Prostatic Gland><Pulmonary Cancer><Pulmonary malignant Neoplasm><Research><Research Career Program><Research Institute><Research Personnel><Research Resources><Research Support><Researchers><Resources><Role><Science><Series><Skeletal Muscle><Specialty><Surgical Castration><Testosterone><Therapeutic Androgen><Therapeutic Testosterone><Thinness><Time><Tissues><Training><Trans-Testosterone><Translational Research><Translational Science><United States><United States National Institutes of Health><Upper Extremity><Upper Limb><Urology><Voluntary Muscle><Woman><Work><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age specific><aged 65 and greater><aged 65+><aged ≥65><ages><androgen ablation therapy><androgen blockade therapy><androgen deprivation therapy><androgen deprivation treatment><associate faculty><associate professor><cardiometabolic><cardiometabolic risk><cardiometabolism><career><clinical center><clinical investigation><cytokine><debilitating symptom><decreased muscle strength><diabetes><dynapenia><endocrine disorder><enroll><erythroid development><frailty><geriatric medicine><hepatic steatosis><hepatosteatosis><human old age (65+)><improved><insulin resistant><insulin tolerance><interest><long-term study><longitudinal outcome studies><longterm study><low muscle strength><lung cancer><malignancy><medical college><medical schools><medical specialties><men><mid-career faculty><midcareer faculty><multidisciplinary><muscle bulk><muscle form><muscle mass><muscle strength><muscle strength decline><muscular><neoplasm/cancer><next generation><novel><old age><older men><over 65 years><pathophysiology><patient oriented research><patient oriented study><pepper><programs><prospective><prostate cancer survivors><prostate survivors><reduced muscle strength><school of medicine><side effect><skills><social role><translation research><translational investigation><≥65 years>