Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DORIT RON · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $499,442 — MODIFIED SPECIFIC AIMS Alcohol has been consumed by humans for more than 4000 years. Luckily, approximately 85%-90% of individuals who consume alcohol socially never develop alcohol use disorder (AUD) symptoms. Using rodents as a model system, we were the first to identify the existence of endogenou…
Adam G Gordon-Fennell · UNIVERSITY OF WASHINGTON · 2024 · $173,167 — Project Summary/Abstract Opioid use has reached epidemic proportions and is now the leading cause of preventable death in the United States. Beyond the risk of death, opioid use disorder causes an incalculable amount of suffering as it devastates the lives of individuals and their communities. The h…
Donald Keith McInnes · EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL · 2024 — Background: On a given night around 40,000 Veterans are homeless and another 300,000 are at risk. Many of these Veterans have complex health and social needs, and they experience frequent residential transitions which can disrupt access to healthcare and treatment adherence. Many persons who are hou…
SARAH E. DAUBER · PARTNERSHIP TO END ADDICTION · 2024 · $251,309 — Abstract The proposed R34 will develop and test digital helpline intervention components aimed at reducing heavy episodic drinking (HED) during the first 3 months postpartum. HED is prevalent among women of reproductive age, and more than half of women who reduce their drinking during pregnancy retu…
Johan Girgenrath · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $33,780 — PROJECT SUMMARY Germline immortality is essential for species survival. Evidence from plants to animals suggests germline immortality depends on small RNA pathways that promote genome stability. In Caenorhabditis elegans germline, small RNAs that interact with the PIWI Argonaute protein PRG-1—called…
Praveen Rao Juvvadi · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2024 · $251,107 — Invasive aspergillosis (IA), caused by the fungus Aspergillus fumigatus, is a leading infectious cause of death in immunocompromised patients. A significant barrier to deciphering the mechanisms of pathogenesis and developing effective antifungals is a lack of understanding of the regulation of A. f…
Tony John Ward · UNIVERSITY OF MONTANA · 2024 · $2,179,141 — Overall Project Summary / Abstract. With just over a million people in the entire state, Montana lacks an adequate healthcare infrastructure throughout our rural areas, contributing to significant and prevalent health disparity issues. These issues can be directly addressed by investing in clinical …
Samuel J Gentle · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $10,000 — SUMMARY This proposed Mentored Patient-Oriented Research Career Development Award (K23) will provide Samuel Gentle, MD, with the mentorship, training, and research experience needed in his transition towards an independent clinician scientist and leader in the field of bronchopulmonary associated pu…
Jackelyn Y Boyden · UNIVERSITY OF PENNSYLVANIA · 2024 · $167,407 — Project Summary/Abstract: An estimated 698,000 children in the U.S. live with serious illness and significant care needs. A complex system of hospital and community providers and agencies supports these children and their families living at home, but families are still challenged by significant gaps…
Erik Steven Musiek · WASHINGTON UNIVERSITY · 2024 · $427,625 — Abstract This proposal leverages a new interdisciplinary collaboration between Drs. Guoyan Zhao and Erik Musiek to define the transcriptional control of astrocyte identities, reactivities, and their roles in in Alzheimer disease (AD) and Parkinson disease (PD) pathogenesis. AD and PD are heterogeneo…
Theodore Lee Roth · STANFORD UNIVERSITY · 2024 · $330,942 — PROJECT SUMMARY/ABSTRACT Cancer immunotherapy has revolutionized oncology. Chimeric Antigen Receptor (CAR) T cells in particular have shown dramatic successes in some liquid tumors, with multiple FDA approved products in overlapping heme indications. Yet patient responses to engineered cell therapie…
Eric E. Alani · CORNELL UNIVERSITY · 2024 · $55,992 — Project Summary DNA mismatch repair (MMR) systems act to excise misincorporation errors that occur during DNA replication. In eukaryotes MSH proteins recognize these errors in the context of base-base and insertion/deletion mismatches and recruit MLH complexes to form ternary complexes that work wit…
Megan DeAnna Radyk · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $125,000 — PROJECT SUMMARY Acinar-to-ductal metaplasia (ADM) is a regenerative state that leads to repair of the pancreas after injury. During ADM, acinar cells transdifferentiate to a duct-like cell and become proliferative. ADM is typically reversible; however, ADM is also a risk factor for the development o…
Christopher David Barrett · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $166,644 — Project Summary The leading cause of death from ages 1-44 years in the United States is traumatic injury, responsible for millions of hospital encounters at a cost of over $4 trillion annually. Unfortunately, outcomes in trauma patients who survive the initial injury have not seen the marked improve…
Edwin Kendrick · SANO HEALTHCARE CONSULTANTS, LLC · 2024 · $319,000 — Significance and Economic Impact: In 2017, the economic burden for opioid use disorder (OUD) was estimated at $68.7 billion for 47,600 persons suffering a fatal opioid overdose ($1.4 million per capita), while nearly 110,000 people are estimated to have died from drug overdoses in 2022.1-5 Medicatio…
Joseph Charles Cooley · NATIONAL JEWISH HEALTH · 2024 · $156,816 — PROJECT SUMMARY This proposal describes a five-year project through which Dr. Joseph Cooley will develop the skills and knowledge necessary to transition into an independent basic and translational physician-scientist. He will receive mentorship from a primary mentor, several advisors and collabora…
MARTIN LEE BLAKELY · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · 2024 · $915,604 — Project summary / abstract Congenital diaphragmatic hernia (CDH) is a complex congenital anomaly where an early embryologic insult disrupts diaphragmatic and pulmonary development, often resulting in severe, acute cardiopulmonary dysfunction post-natally and affects 2-4 per 10,000 births in the US, …
Lu Chen · STANFORD UNIVERSITY · 2024 · $77,357 — Principal Investigator: Chen, Lu Summary Our research focuses on uncovering the molecular mechanisms of a form of non-Hebbian synaptic plasticity, namely homeostatic synaptic plasticity. In contrast to the self-reinforcing nature of Hebbian plasticity, homeostatic plasticity operates under differen…
MARIA LEHTINEN · BOSTON CHILDREN'S HOSPITAL · 2024 · $65,297 — PROJECT SUMMARY (Parent Grant) Post-hemorrhagic hydrocephalus (PHH) is a leading cause of morbidity in premature infants. PHH is triggered by germinal matrix intraventricular hemorrhage (IVH) that results in accumulation of cerebrospinal fluid (CSF) in the brain, compression of surrounding brain tis…
BENEDICT J KOLBER · UNIVERSITY OF KENTUCKY · 2024 · $360,514 — PROJECT SUMMARY/ABSTRACT There is a pressing need to identify and validate new targets for chronic pain and new sources for novel compounds. This proposal will use novel extracts and pure compounds from multiple Cameroonian plants namely Paullinia pinnata, Petersianthus macrocarpus and Acacia siebe…