NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CORINNA GEHRETT LEVINE · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $154,440 — PROJECT SUMMARY/ ABSTRACT Goal: This proposal provides a structured research training program under the guidance of mentors and advisors in related fields to promote Dr. Levine’s development into an independent clinician-scientist. Her long-term goal is leading a multidisciplinary research teams to …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Brian K. Law · UNIVERSITY OF FLORIDA · 2024 · $165,076 — Breast cancer remains a major killer of women due to the ineffectiveness of current drugs against metastatic and drug-resistant cancers. Additionally, African American (AA) women suffer disproportionately from breast cancer mortality in part because they develop the aggressive Triple- Negative Breas…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Hui Hu · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $507,907 — Project Summary T follicular helper (Tfh) cells are essential for germinal center (GC) responses and long-term humoral immunity. However, the complex regulation that determines the differentiation of Tfh cells, in particular, the initial CXCR5– versus CXCR5+ CD4+ T cell differentiation, the develop…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Loren David Walensky · DANA-FARBER CANCER INST · 2024 · $999,639 — PROJECT SUMMARY/ABSTRACT BCL-2 proteins participate in a dynamic interaction network that determines whether a cell will live or die. Deregulation of this essential signaling pathway underlies the pathogenesis of human cancer and resistance to treatment. The goal of this R35 research program is to e…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Siobhan Sutcliffe · WASHINGTON UNIVERSITY · 2024 · $351,511 — ABSTRACT Lower urinary tract symptoms (LUTS), including storage, voiding, urinary incontinence symptoms and pain, and their associated diagnoses are common, costly, and negatively impact women's quality of life throughout the life course. Despite their common occurrence and high cost, little researc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Whitney Jean Bell · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $40,491 — Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest adult cancers with a 5-year survival rate of only 11% and is one of the top five leading causes of cancer-related deaths for men and women in the United States. These dire statistics underscore the need for a better understandi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Jennifer Crowe · UNIVERSIDAD NACIONAL, COSTA RICA · 2024 · $450,000 — PROJECT SUMMARY Chronic kidney disease of unknown origin (CKDu) is highly prevalent in several tropical regions, including Central America where it is most common among young adult males working in sugarcane and other agricultural activities. It has taken a terrible toll on families living in vulner…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Winston Chiong · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $2,374,537 — PROJECT SUMMARY/ABSTRACT Dementia caregivers, clinicians, and researchers can experience deep ethical conflicts when people with dementia express strong preferences about personal care, finances, clinical management or research participation that depart from values that they had previously espoused.…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JONATHAN D NEWMAN · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $828,434 — PROJECT ABSTRACT Air pollution is responsible for >213,000 excess deaths in the U.S. annually, and globally remains the 4th leading cause of mortality. Further, most air pollution-related mortality is due to cardiovascular (CV) disease. We and others have found that short term air pollution exposure…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ling Yang · UNIVERSITY OF IOWA · 2024 · $473,076 — PROJECT SUMMARY Dysregulated metabolic function and chronic inflammation are prominent features of obesity in both humans and animal models. Brown adipose tissue (BAT) plays a critical role in metabolic adaptation in response to stresses including overnutrition, wherein the metabolic adaptation is d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Chaolin Zhang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $906,022 — Complexity and evolution of splicing-regulatory networks Project Summary Alternative splicing (AS) generates multiple transcript isoforms from single genes and contributes critically to the molecular, cellular and phenotypic complexity of mammals. This process is tightly regulated by RNA-binding pro…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Basak Elif Uygun · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $356,378 — ABSTRACT Deformities created by birth defects, trauma, inflammation, and medical conditions including cancer constitute a significant global health burden accounting for 11% of worldwide disability-adjusted life years and can be corrected by reconstructive surgery. Standard reconstructive technique…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tatsuya Tsukui · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $248,947 — PROJECT SUMMARY Pulmonary fibrosis is a chronic and intractable disease with a 5-year survival rate comparable to pancreatic or lung cancers. Deterioration of respiratory function in pulmonary fibrosis is caused by progressive replacement of normal tissue for gas exchange to dense fibrotic scar with…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Wei Wang · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · 2024 · $193,616 — PROJECT SUMMARY/ABSTRACT My long-term career goal is to become an independent scientist in an academic research institution. My research interest focuses on investigating novel molecular mechanisms underlying immunosuppression in tumor microenvironment to provide new therapeutic targets and approach…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Vernon Bruce Carruthers · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $195,000 — Abstract ESCRT protein complexes play essential roles in membrane remodeling for multivesicular body formation, intercellular communication, formation of the nuclear envelope, and cell division. We recently showed that the obligate intracellular parasite Toxoplasma gondii repurposes host ESCRT machi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
MARIA ADELA GRANDO · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $632,566 — PROJECT SUMMARY Integrated care is critical and becoming more common, but balancing the privacy needs of patients with substance use disorders (SUD) and increasing patient safety through data access is a challenge to realizing its full potential. Our previous award (R01MH108992) found: 1) a general …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Naomi Ilana Eisenberger · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $196,875 — Project Summary Adolescents demonstrate a high need for emotion regulation [2-4], but often struggle to employ gold- standard regulatory strategies such as cognitive reappraisal due to underdeveloped lateral prefrontal neuroarchitecture (i.e. lateral prefrontal cortex (LPFC)), which plays a crucial…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ashley Mello · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $41,664 — PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple deadly cancers, single-agent checkpoint immunotherapy has been largely ineffective in PDAC. This la…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
DAVID WEINSHENKER · EMORY UNIVERSITY · 2024 · $463,811 — Project Summary The opioid epidemic has been declared a national public health emergency. Current treatments have abuse liability, target acute overdose only, and/or are ineffective for many people suffering from opioid addiction, and new therapies are desperately needed. One promising target is the…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Alida M Bouris · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $603,857 — Project Summary Among people living with HIV (PLWH), positive affect is uniquely associated with lower levels of depression, slower disease progression, better adherence to medication, and higher likelihood of achieving suppressed viral load, independent of negative affect. In two randomized control…