Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Shanmugasundaram Nallasamy · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $436,511 — Project Summary Early pregnancy loss is the most prevalent early pregnancy complication, and its incidence is estimated to be ~75%. Thus, delineating the mechanisms of peri and post-implantation processes will help reduce this adverse pregnancy outcome. Decidualization, a process of stromal cell pro…
MARIA LUISA GORNO TEMPINI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $5,446,505 — PROJECT SUMMARY—Frontotemporal Dementia (FTD): Genes, Images, and Emotions Frontotemporal dementia (FTD) research is entering a new era of therapeutic discovery, spurred in part by contributions from this program project grant (PPG), entitled “Frontotemporal Dementia: Genes, Images, and Emotions,” w…
GERALD MCGWIN · UNIVERSITY OF MINNESOTA · 2024 · $1,144,582 — Project Summary Lower urinary tract symptoms (LUTS) encompass a variety of bothersome storage and emptying symptoms, including urgency and stress urinary incontinence, frequent and/or urgent urination, nocturnal enuresis (i.e., bed-wetting), difficulty urinating, dribbling after urination, and bladd…
Mikaela Elizabeth Simon · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $37,752 — PROJECT SUMMARY/ABSTRACT During pregnancy, maternal and extraembryonic cells interact at the uterine-placental interface, facilitating adaptations that promote fetal growth. Trophoblast stem (TS) cells differentiate and invade into the uterus during pregnancy. When invasive trophoblast cells fail to…
Scott Evans · GEORGE WASHINGTON UNIVERSITY · 2024 · $450,604 — PROJECT SUMMARY ABSTRACT The goal of the Exercise and Nutrition Interventions to Improve Cancer Treatment-related Outcomes (ENICTO) Consortium is to support and enhance exercise and/or medical nutrition intervention research designed to evaluate interventions that may improve cancer treatment-relate…
ANA CRISTINA TERRA DE SOUZA LINDSAY · UNIVERSITY OF MASSACHUSETTS BOSTON · 2024 · $190,625 — PROJECT SUMMARY Human papillomavirus (HPV) is the most common sexually transmitted virus in the United States (U.S.). HPV infection is linked to cancers of the cervix, vulva, vagina, penis, anus, and oropharynx, thus representing a significant public health concern. The HPV vaccine is the most effic…
Amaia Lujambio · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $367,259 — PROJECT SUMMARY (from parent application) Hepatocellular carcinoma (HCC) represents a major health problem, causing more than 700,000 deaths annually worldwide. Although HCC treatment has greatly improved over the last decades, most HCC patients diagnosed at advanced stages are ineligible for curati…
Jonathan Allen Webster · JOHNS HOPKINS UNIVERSITY · 2024 · $237,049 — Project Summary Dr. Jonathan Webster is an Assistant Professor of Oncology in the Division of Hematologic Malignancies at The Johns Hopkins University School of Medicine. He is a member of the Leukemia Group and has completed the Science of Clinical Investigation curriculum at the Johns Hopkins Bloo…
Elizabeth Anne Grice · UNIVERSITY OF PENNSYLVANIA · 2024 · $812,364 — PROJECT SUMMARY The Penn Skin Biology and Diseases Resource-based Center (Penn SBDRC) will continue to support and accelerate skin disease research and its translation by providing critical infrastructure, resources, and expertise to skin investigators. The overall goals of the Penn SBDRC are to pro…
Jixin Dong · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $556,553 — Abstract Text Many antitubulin agents, such as paclitaxel (Taxol), have been used extensively for treatment of several types of cancer, including ovarian, lung, pancreatic, and breast cancers. Despite their wide use in cancer treatment, however, patient response is highly variable and drug resistanc…
Marnie Skinner · JOHNS HOPKINS UNIVERSITY · 2024 · $48,974 — Infertility effects around 15% of couples that are of reproductive age worldwide. Issues relating to infertility often arise due to errors in the process of meiosis, the specialized cell division where a single diploid cell gives rise to four haploid gametes. The general sequence of events in meiosi…
Adrian Erlebacher · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $1,633,501 — In the U.S., about 12% of women have impaired fecundity and 7% of couples have infertility, with 1/3 attributable to female factors. Underlying mechanisms remain largely unknown, however, even when more proximal pathologies are identified, thus precluding the development of accurate diagnostics and …
Mary Kay Lobo · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $525,941 — Project Summary: Drug abuse is a debilitating relapsing disease characterized by compulsive drug seeking and use despite negative personal consequences. Repeated exposure to drugs of abuse is accompanied by persistent alterations in molecular processes, including alterations in transcription factor…
KATYA RAVID · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $412,500 — ABSTRACT Platelet counts are tightly regulated in order to prevent thrombotic or hemorrhagic complications associated with thrombocytosis or thrombocytopenia, respectively. While strides have been made in our understanding of proplatelet formation (PPF), there is still limited knowledge regarding th…
Stephan Sanders · UNIVERSITY OF OXFORD · 2024 · $439,038 — ABSTRACT Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal and early postnatal development and across brain regions. Disruptions of these developmentally dynamic processes have been…
Melanie Maria Ott · J. DAVID GLADSTONE INSTITUTES · 2024 · $915,998 — PROJECT SUMMARY Recent data suggest that a substantial fraction of the HIV reservoir persisting in the face of antiretroviral therapy (ART) is transcriptionally active and may contribute to the chronic inflammation observed in people with HIV (PWH). This is particularly pertinent in elderly PWH, wh…
Stephen T Higgins · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · 2024 · $1,113,044 — PROJECT SUMMARY Overall Plan The overarching goal of this application for a Phase 3 Center of Biomedical Research Excellence (COBRE) award is to firmly establish the Vermont Center on Behavior and Health (VCBH) at the University of Vermont (UVM) as a sustainable center of research excellence. This m…
DANA H. BOVBJERG · DUKE UNIVERSITY · 2024 · $590,996 — Abstract Persistent pain following breast cancer surgery is increasingly recognized as an important clinical and public health issue due to the large number of women affected, the powerful negative impact that persistent pain has on emotional and physical functioning and its financial costs. Most of…
Samuel Eallonardo · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $21,501 — Abstract Pregnant women are more likely to be infected with the intracellular pathogen Listeria monocytogenes (Lm) than the general population, and the bacterium can be vertically transmitted leading to fetal infection and pregnancy loss. Despite its public/health/relevance, the determinants of mat…
Natalie Lynn Andras · OHIO STATE UNIVERSITY · 2024 · $54,774 — Project Summary In the United States, 47% of adults 30 years or older are affected by periodontal disease, and this rate increases with age to 70% in adults 65 years or older. The periodontal complex, consisting of alveolar bone, cementum, gingiva, and the periodontal ligament (PDL), works to ensure…