NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lara K Dhingra · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $546,217 — PROJECT SUMMARY More than 500,000 patients with end-stage kidney disease (ESKD) receive chronic hemodialysis (HD) in the U.S. each year. The prevalence of ESKD/HD is increasing, particularly among racial/ethnic minorities. There is a compelling need to address the many clinical concerns that ESKD/H…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Audrey Christine Brumback · UNIVERSITY OF TEXAS AT AUSTIN · 2024 · $778,590 — PROJECT SUMMARY The mediodorsal thalamus (MD) and its reciprocal connection with medial prefrontal cortex (mPFC) control important aspects of executive functioning and social behavior. Dysfunction of this neural circuit can cause developmental brain disorders and neuropsychiatric conditions. Underst…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CRAIG ALTIER · CORNELL UNIVERSITY · 2024 · $390,304 — PROJECT SUMMARY ABSTRACT Infections by Salmonella present a constant threat to human health in our country and throughout the world. Yet, our progress toward controlling salmonellosis has been largely fruitless; antibiotics are rarely warranted, and, when used, frequently fail due to resistant strai…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ANGELA L F GIBSON · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $280,617 — No changes Project Summary: Tissue necrosis is a form of cell death caused by a wide variety of diseases and injuries. Current methods of detecting tissue necrosis to guide surgical decision making are limited. In burn injury, clinical visualization of tissue necrosis is the standard of care; howeve…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Erie D Boorman · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $522,104 — Abstract Cognitive maps refer to internal representations of spatial and non-spatial relationships between entities (people or things) or events in the external world. There has been widespread excitement generated by recent discoveries that even continuous non-spatial task dimensions may be organiz…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Yajing Wang · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $359,006 — With continually improving reperfusion strategies, the overall mortality of AMI has been significantly reduced in non-diabetic patients. However, both the prevalence and severity of ischemic heart failure (IHF) continually escalate in patients with type 2 diabetes. Identifying risk factors, patholog…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Zhefeng Guo · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $188,632 — Project Summary/Abstract Aggregation of Aβ protein plays a central role in the pathogenesis of Alzheimer's disease. Aβ aggregation leads to the formation of soluble oligomers and insoluble fibrils. While amyloid fibrils are the main component of parenchymal plaques in Alzheimer's disease brains, th…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Karyn M Frick · UNIVERSITY OF WISCONSIN MILWAUKEE · 2024 · $399,300 — PROJECT SUMMARY The University of Wisconsin-Milwaukee Promoting Equity, Diversity, and Academic Success through Aging Research (UWM STAR) program is a training program aimed at increasing the participation of BIPOC (Black, Indigenous, People of Color) students in research focused on reducing health …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Davood Karimi · BOSTON CHILDREN'S HOSPITAL · 2024 · $376,745 — Project Summary The goal of this project is to enhance the capabilities of diffusion-weighted magnetic resonance imaging (dMRI)for neonatal and pediatric subjects. Currently, dMRI is the only viable non-invasive method for probing brain microstructure. The past two decades have witnessed development…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
ADITYA Devidas Mahadevan · UNIVERSITY OF FLORIDA · 2024 · $43,163 — PROJECT SUMMARY/ABSTRACT The primary goal of this proposal is to provide a framework of methodologically-diverse, and clinically-inclined, investigative training that will prepare the principal investigator for a successful career as a translational physician-scientist. In addition to MD/PhD-specifi…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JEFFREY D DVORIN · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $259,646 — Project Summary Malaria parasites quickly amplify their numbers in both the human host and mosquito vector, with a single parasite capable of creating dozens, hundreds, or thousands of daughter parasites. The formation of merozoites (asexual blood stage, liver stage) or sporozoites (mosquito stage) …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Amelia Kent Wesselink · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $392,063 — PROJECT SUMMARY Infertility is an important public health problem that affects up to 15% of reproductive-aged couples in the United States. Black women experience infertility at approximately two times the rate of white women, yet are less likely to seek medical care and have poorer fertility treatm…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Grant Anthony Challen · WASHINGTON UNIVERSITY · 2024 · $422,691 — ABSTRACT Blood diseases such as myelodysplastic syndromes (MDS) arise from hematopoietic stem cells (HSCs) that acquire genetic mutations which corrupt critical HSC functions. One of the most recurrently mutated genes in these neoplasms is the de novo DNA methyltransferase enzyme DNMT3A. However, D…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Daniel Kahne · HARVARD UNIVERSITY · 2024 · $726,665 — Project Summary/Abstract Infections due to Gram-negative bacteria and mycobacterium tuberculosis (Mtb) pose a serious threat to human health. These organisms produce especially complex cell envelopes consisting of a double layer of membranes that are essential for survival. This cell envelope also f…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Tiffany LaShaun Carson · H. LEE MOFFITT CANCER CTR & RES INST · 2024 · $596,832 — Black females have the highest prevalence of overweight and obesity than any other racial-gender group in the United States with 4 out of 5 adult black females being overweight or obese. Furthermore, adult black females tend to lose less weight than whites undergoing the same obesity intervention re…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Michele Insanally · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $489,915 — Project Summary Neurons throughout the auditory system are remarkably plastic, allowing auditory circuits to flexibly adapt to changing task demands and context. Flexible auditory behavior is the result of a dynamic interaction between several auditory regions including upstream and downstream areas…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Ryan Lynn Ashley · NEW MEXICO STATE UNIVERSITY LAS CRUCES · 2024 · $370,000 — Project Summary/Abstract Impaired placental function leads to dangerous pregnancy complications such as preeclampsia, intrauterine growth restriction, placental abruption, and stillbirth. Placental dysfunction is the leading cause of maternal, fetal, and neonatal morbidity and mortality worldwide an…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
CATHERINE L ELSINGER · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $362,261 — Project Summary Functional localization of eloquent brain areas for patients undergoing surgery for brain tumors, epilepsy, or other neurological diseases is crucial to prevent post-surgical deficits and reduce morbidity. Task-based (tb) functional MRI (fMRI), which detects blood oxygenation level–d…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Elizabeth Hesper Rego · YALE UNIVERSITY · 2024 · $415,555 — Abstract Tuberculosis (TB), a bacterial infection caused by Mycobacterium tuberculosis (Mtb), is now the leading cause of death by a single infectious agent. One reason for this is that subpopulations of Mtb cells can survive even lengthy chemotherapy, preventing cure of disease. These surviving cel…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Kimberly Patrice Hreha · DUKE UNIVERSITY · 2024 · $122,989 — PROJECT SUMMARY/ ABSTRACT This is an application for a K01 Mentored Research Scientific Development Award. The goal of the proposed project is to provide the candidate with the advanced skills needed to establish an independent research program examining the visual health needs of stroke survivors a…