Document text
Principal Investigator: Kimberly Patrice Hreha
Organization: DUKE UNIVERSITY
Fiscal Year: 2024
Award: $122,989
Funding agency: Eunice Kennedy Shriver National Institute of Child Health and Human Development
PROJECT SUMMARY/ ABSTRACT
This is an application for a K01 Mentored Research Scientific Development Award. The goal of the proposed
project is to provide the candidate with the advanced skills needed to establish an independent research program
examining the visual health needs of stroke survivors also living with dementia. To facilitate this long-term goal,
the candidate proposes a comprehensive training plan, combining formal coursework and meetings overseen
by her mentors, participation in applied training experiences and involvement in seminars and workshops.
Specific training goals include: (1) gain advanced knowledge in the epidemiology and mechanisms of post-stroke
dementia, (2) learn neuropsychological and clinical assessment of dementia, (3) acquire skills and training in
clinical research methodology and statistical analysis, using both cross sectional and longitudinal data and (4)
productively participate in career advancement and leadership development activities. The training plan will be
executed in coordination with the set of research activities mentioned above, which are based on preliminary
data collected by the applicant. The preliminary data show a lack of research on whether the presence of specific
types of vision impairment and ocular deficits increase the risk of post-stroke dementia.
The candidate will expand on these findings by using data from the Atherosclerosis Risk in Communities stroke
cohort to complete the following aims: (1) characterize the prevalence and outcomes associated with vision
impairment(s) among stroke survivors with and without dementia; (2) determine how pre-existing vision
impairments impact the development of dementia, among those with stroke; and (3) determine the effect and
downstream consequences of post-stroke vision impairment in persons without pre-existing vision impairment.
The primary hypotheses include that: (1) the odds of developing dementia are higher for stroke survivors with
pre-existing vision impairment, compared to stroke survivors with normal vision; (2) stroke survivors with vision
impairment preceding the stroke are more likely to develop dementia earlier, compared to stroke survivors with
normal vision; and (3) the impact of post-stroke vision impairment on dementia development is stronger for those
with functional impairment, compared to those without functional impairment. The expected findings will provide
critical insight into the types of vision impairment and ocular deficits experienced by people with post-stroke
dementia, including more information on the significance of distinguishing between pre- and post-stroke visual
impairments and the expected differential impact on dementia. Results from this research will be used to develop
a subsequent R01 research proposal that will facilitate the candidate’s transition into an independent researcher
focused on analysis of existent data and prospective enrollment to optimize the independence and community
participation of stroke survivors with vision impairments and dementia.
Terms: <Address><Advanced Development><Age><Age related macular degeneration><Age-Related Maculopathy><Amentia><Apoplexy><Atherosclerosis Risk in Communities><Award><Brain Vascular Accident><Career Mobility><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Characteristics><Clinic><Clinical><Clinical Research><Clinical Study><Clinical assessments><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Community Participation><Complex><Data><Data Set><Dementia><Development><Diminished Vision><Disease><Disorder><Disturbance in cognition><Early Diagnosis><Educational workshop><Emotional Depression><Enrollment><Epidemiology><Eye diseases><Functional impairment><Funding><Future><Goals><Health><Health Services Evaluation><Health Services Research><Impaired cognition><Individuals from minority><Individuals of minority><Individuals with physical disabilities><Intervention><Intervention Strategies><Investigators><Knowledge><Learning><Low Vision><Mediating><Medical Care Research><Medical center><Mental Depression><Mental Health><Mental Hygiene><Mentors><Mentorship><Methods><Minority Groups><Minority People><Minority Population><Minority individual><Neurologic><Neurological><Neuropsychologies><Neuropsychology><Occupational Therapist><Outcome><Partial Sight><Persons><Persons with Physical Disabilities><Population><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Productivity><Psychological Health><Reduced Vision><Research><Research Activity><Research Methodology><Research Methods><Research Personnel><Research Proposals><Researchers><Risk><Services><Sight><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stroke><Subnormal Vision><Survey Instrument><Surveys><Testing><Training><Training Activity><Vision><Visual><Visual impairment><Vulnerable Populations><Work><Workshop><after stroke><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><ages><analyzing longitudinal><brain attack><career advancement><career development><career transition><cerebral vascular accident><cerebrovascular accident><cognitive dysfunction><cognitive loss><cohort><dementia after stroke><dementia risk><depression><depression symptom><depressive><depressive symptoms><developmental><direct application><early detection><enroll><epidemiologic><epidemiological><experience><eye disorder><functional independence><functional status><improved><innovate><innovation><innovative><insight><interventional strategy><leadership development><longitudinal analysis><meeting><meetings><neuropsychologic><novel><ocular disease><ocular disorder><ophthalmopathy><post stroke><post stroke dementia><poststroke><poststroke dementia><programs><prospective><psychologic><psychological><rehab research><rehabilitation research><research and methods><risk factor for dementia><risk for dementia><senile macular disease><services research><skill acquisition><skill development><skills><statistical analysis><stroke survivor><stroked><strokes><symptomatology><training module><vision impairment><visual function><visually impaired><vulnerable group><vulnerable individual><vulnerable people>