Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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TERRY L. SHEPPARD · KEYSTONE SYMPOSIA · 2024 · $12,000 — ABSTRACT Support is requested for a Keystone Symposia conference entitled Epigenetic Mechanisms and the Treatment of Cancer, organized by Drs. Tony Kouzarides, Rab Prinjha and Marisa Bartolomei. The conference will be held in Santa Fe, New Mexico from February 4 - 7, 2024. This Keystone Symposia Epi…
LISA M MONTEGGIA · VANDERBILT UNIVERSITY · 2024 · $532,105 — Project Summary In the previous funding period we investigated the mechanism of rapid antidepressant activity of ketamine, an ionotropic glutamatergic n-methyl-d-aspartate (NMDA) receptor antagonist. We demonstrated that Brain- derived neurotrophic factor (BDNF), and its high affinity receptor TrkB,…
ANITA H. CORBETT · EMORY UNIVERSITY · 2024 · $369,822 — Project Summary Post-transcriptional control of mRNAs plays a key role in regulating important developmental events via RNA binding proteins (RBPs) that modulate key aspects of RNA fate, including splicing, stability, and translation. Developmental roles of RBPs are particularly evident in the nervo…
Kurt C. Marsden · NORTH CAROLINA STATE UNIVERSITY RALEIGH · 2024 · $361,883 — Project Summary. A fundamental function of the nervous system is to distinguish between threatening and non- threatening stimuli. For example, a sudden intense sound that indicates danger should trigger an acoustic startle response, but an innocuous sound should not. This type of behavioral threshol…
Alice M Graham · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $20,000 — Neurodevelopmental disorders, including psychiatric symptoms and learning disabilities, and substance use, remain public health concerns as they can lead to suboptimal educational and occupational outcomes in adolescence and adulthood. Human brain development is a complex process that begins in the …
James B Konopka · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $528,804 — Project Summary The human fungal pathogen Candida albicans is a leading cause of hospital-acquired bloodstream infections and can disseminate to become lethal. There is an urgent need to improve the therapeutic management of C. albicans infections, since current antifungal drugs have limited effect…
Mario Feldman · WASHINGTON UNIVERSITY · 2024 · $681,308 — PROJECT SUMMARY/ABSTRACT Multidrug resistant (MDR) infections caused by the bacterial pathogen Acinetobacter baumannii are increasing at alarming rates. Currently, over 60 % of global A. baumannii clinical isolates are MDR, leading the Centers for Disease Control and Prevention and the World Health …
Trever G Bivona · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $636,702 — PROJECT ABSTRACT. Lung cancer is the leading cause of cancer mortality worldwide, with non-small cell lung cancer (NSCLC) the predominant histologic subtype of lung cancer and lung adenocarcinoma the major subset of NSCLC. ALK gene rearrangements (e.g., EML4-ALK fusions) are validated targets in NSC…
Waranuch Pitiphat · KHON KAEN UNIVERSITY · 2024 · $148,522 — ABSTRACT Oral diseases pose a major health challenge globally and affect people throughout their lifetime. These diseases share common risk factors with other major Chronic Non-communicable Diseases and Disorders (NCDs). The well-established oral-systemic health connections also indicate that preven…
Elaine I Tuomanen · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $455,000 — Antibiotic resistance and tolerance are a major increasing threat to treating infectious diseases. Streptococcus pneumoniae, the leading cause of pneumonia, sepsis, and meningitis worldwide, is a model organism for understanding antibiotic-induced autolysis and failure of therapy due to antibiotic t…
Tammy Chang · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $612,742 — ABSTRACT Excess weight gain during pregnancy among low income pregnant youth is associated with serious multi- generational morbidity for both the mother and infant. Healthy diet and limiting sugar sweetened beverages during pregnancy promotes healthy weight gain during pregnancy and impacts permane…
Yufei Huang · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $547,795 — Project Summary N6-methyl-adenosine (m6A) is the most abundant mRNA methylation in mammalian cells. Emerging evidence has linked m6A with cancer phenotypes in many cancers, spurring a surge of research in studying m6A and cancer biology. However, dysregulation of m6A effector writers, erasers, and r…
Hongkuan Fan · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $620,701 — PROJECT SUMMARY/ABSTRACT Vascular dysfunction, such as decreases in cerebral blood flow (CBF) and disruption of the blood brain barrier (BBB) are early symptoms of Alzheimer’s disease (AD) and could contribute to AD onset and progression. In the brain, specialized cells called pericytes are integra…
Dexter Pratt · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $820,585 — THE NETWORK DATA EXCHANGE – A NETWORK COMMONS FOR BIOLOGISTS PROJECT SUMMARY Knowledge of biological networks has been critical to the analysis of big biomedical datasets, including interpretation of the molecular heterogeneity seen within and across tumors. NDEx, the Network Data Exchange (ndexbio.…
Elena Myasoedova · MAYO CLINIC ROCHESTER · 2024 · $190,142 — PROJECT SUMMARY/ABSTRACT This K24 application seeks to provide protected time for Dr. Elena Myasoedova to mentor trainees in patient- oriented research (POR) aiming at defining the long-term temporal relationship between systemic inflammation, cardiovascular risk factors and cardiovascular events on…
Tatiana T. Marquez-Lago · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2024 · $336,295 — Despite decades-long research and multiple trials, there is no licensed vaccine against Cytomegalovirus (CMV) yet, urging efforts to better understand its transmission dynamics. CMV is a frequent cause of tissue-invasive disease in infants and immunocompromised individuals, and transmission happens …
Andrei Ivanovich Ivanov · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $604,875 — ABSTRACT Over their disease course more than half of Crohn’s disease (CD) patients develop fibrosis-induced intestinal obstruction and ultimately require surgery. No specific anti-fibrotic therapies are available. Despite advances of anti-inflammatory therapies the incidence of strictures remains hi…
Serap AKSOY · BIOTECHNOLOGY RESEARCH INSTITUTE-KALRO · 2024 · $248,357 — Vector-borne and neglected tropical diseases (VBDs and NTDs, respectively) are endemic and emerging threats in sub-Saharan Africa (sSA). In this renewal application, scientists from Kenya Agricultural and Livestock Research Organization, Biotechnology Research Institute (BioRI-KALRO), and Yale Schoo…
Margaret Kathryn Tamburro · UNIVERSITY OF PENNSYLVANIA · 2024 · $48,974 — Project Abstract Tendons can withstand large forces due to a highly aligned, dense collagen matrix. However, their low cellularity and relative inability to recruit reparative cells post-injury, as well as susceptibility to excessive scarring, results in loss of tendon structure and mechanical funct…
Gracie Vargas · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $244,865 — PROJECT SUMMARY The UTMB ‘PREPing for SUCCESS’ PREP program is designed to provide promising post-baccalaureate trainees from groups underrepresented in the sciences (underrepresented minorities, persons with disabilities, socioeconomically disadvantaged students) demonstrating an aptitude for resea…