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Principal Investigator: Elena Myasoedova
Organization: MAYO CLINIC ROCHESTER
Fiscal Year: 2024
Award: $190,142
Funding agency: National Institute on Aging
PROJECT SUMMARY/ABSTRACT
This K24 application seeks to provide protected time for Dr. Elena Myasoedova to mentor trainees in patient-
oriented research (POR) aiming at defining the long-term temporal relationship between systemic inflammation,
cardiovascular risk factors and cardiovascular events on the risk of Alzheimer’s Disease and other related
dementias (ADRD), using rheumatoid arthritis (RA) as a prototype. This award will enable the applicant to solidify
and advance her current NIA-funded R01 research program in new directions and to expand her mentoring
opportunities and mentoring experience. Dr. Myasoedova is a tenure-track Associate Professor at Mayo Clinic.
She has a strong and ongoing record of high-quality POR, publication, and mentoring in research directly related
to the proposed studies. The applicant has shown significant abilities in mentoring trainees at all career stages
and will continue to benefit from the rich and robust resources, unique research infrastructure and a large pool
of patients and mentees at Mayo Clinic. During the funding period, further development of the applicant will
include: 1) Improvement in mentorship skills in POR; 2) Enhancement of knowledge in biostatistics for POR; 3)
Development of a collaborative niche for POR in aging and ADRD in rheumatic diseases; and 4) Maintaining
uninterrupted extramural funding. These goals will be achieved through a combination of seminars, meetings,
courses, and collaboration with the Division of Epidemiology, the Kogod Center on Aging, the Rochester
Epidemiology Project and the Mayo Clinic Study on Aging. Dr. Myasoedova will further integrate and advance
these skills through continued mentorship of trainees within currently funded POR and through expansion of her
ADRD research through the K24 mechanism. Research aims of the proposal include: 1) Examining the temporal
association between cardiovascular risk factors, systemic inflammation and ADRD in RA; 2) Evaluating direct
and cardiovascular-mediated effects of chronic inflammation on ADRD in RA; and 3) Defining the population
attributable risk (PAR) of RA characteristics on incident mild cognitive impairment and ADRD, overall and by
sex. The proposed studies will inform risk stratification of ADRD in a chronic inflammatory setting of RA overall
and by sex as a key step for advancing the understanding of ADRD risk and developing prevention strategies in
patients with RA and beyond. These aims are well-aligned with NIA’s Goal D to improve our understanding of
the aging brain and ADRD, specifically defining the impact of inflammatory processes on the development of
AD, and whether systemic risk factors such as obesity, diabetes, hypertension, and heart disease during midlife
are associated with accelerated age-related cognitive decline and with increased risk for AD. Successful
completion of this award will facilitate the development of the next generation of patient-oriented researchers in
ADRD and will expand Dr. Myasoedova’s POR program to ensure continued mentoring opportunities into the
future, aligning with the NIA’s mission to “Foster the development of research and clinician scientists in aging’.
Terms: <AD dementia><AD prevention><AD related dementia><ADRD><Accounting><Active Follow-up><Address><Age><Age-associated cognitive decline><Age-associated memory impairment><Age-related cognitive decline><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease biological marker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Alzheimer’s biological marker><Alzheimer’s disease biomarker><Amentia><Anti-Rheumatic Agents><Anti-Rheumatic Drugs><Atrophic Arthritis><Autoimmune><Autoimmune Status><Autoimmunity><Award><Benign senescent forgetfulness><Biological Agent><Biological Products><Biometrics><Biometry><Biostatistics><C-reactive protein><Cardiac Diseases><Cardiac Disorders><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Characteristics><Chronic><Clinic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Data><Dementia><Development><Development and Research><Diabetes Mellitus><Disease><Disorder><Disturbance in cognition><EXTMR><Ensure><Epidemiology><Erythrocyte Sedimentation Rate><Event><Evolution><Extramural><Extramural Activities><Female><Fostering><Funding><Future><Goals><Heart Diseases><Heart Vascular><Hyperlipemia><Hyperlipidemia><Hypertension><Immune system><Immunomodulation><Impaired cognition><Incidence><Inflammation><Inflammatory><Infrastructure><Intervention><Intervention Strategies><Investigators><K24 Award><K24 Mechanism><K24 Program><Knowledge><Leadership><Lipids><Longitudinal Studies><Mediating><Mentors><Mentorship><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Mission><Musculoskeletal Pain Disorder><NIH><National Institutes of Health><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurological Damage><Neurological Injury><Neurological trauma><Obesity><Older Population><Patients><Phenotype><Population Attributable Risks><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Prevention><Primary Senile Degenerative Dementia><Process><Proteins, specific or class, C-reactive><Public Health><Publications><Publishing><R & D><R&D><Research><Research Infrastructure><Research Personnel><Research Resources><Research Support><Researchers><Resources><Rheumatic Diseases><Rheumatism><Rheumatoid Arthritis><Rheumatologic Diseases><Rheumatologic Disorder><Risk><Risk Factors><Role><Scientific Publication><Scientist><Time><United States National Institutes of Health><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Woman><accelerated aging><accelerated biological age><accelerated biological aging><active followup><adiposity><age acceleration><age associated><age associated memory decline><age correlated><age dependent><age linked><age related><age related cognitive deficit><age related cognitive impairment><age related memory dysfunction><age specific><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging brain><alzheimer risk><associate faculty><associate professor><attributable fraction><biologics><biopharmaceutical><biotherapeutic agent><cardiac disease induced cognitive impairment><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular risk><cardiovascular risk factor><career><chronic inflammatory disease><circulatory system><co-morbid><co-morbidity><cognitive dysfunction><cognitive loss><cognitive performance><cohort><comorbidity><corpulence><dementia risk><developmental><diabetes><disease model><disorder model><epidemiologic><epidemiological><experience><follow up><follow-up><followed up><followup><heart disorder><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><indexing><inflammation marker><inflammatory marker><innovate><innovation><innovative><interventional strategy><late life><long-term study><longitudinal outcome studies><longterm study><meeting><meetings><men><metabolic profile><mid life><mid-career faculty><mid-life><midcareer faculty><middle age><middle aged><midlife><mild cognitive disorder><mild cognitive impairment><neuroimaging biomarker><neuroimaging marker><neurotrauma><next generation><novel><older groups><older individuals><older person><patient centered><patient oriented><patient oriented research><patient oriented study><population based><prevent><preventing><primary degenerative dementia><programs><prototype><research and development><rheumatic arthritis><risk factor for dementia><risk for dementia><risk stratification><senile dementia of the Alzheimer type><sex><skills><social role><socio-demographics><sociodemographics><stratify risk><systemic inflammation><systemic inflammatory response><tenure process><tenure track><therapeutic target><vascular cognitive impairment and dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive impairment and dementia>