Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Eric P Skaar · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $498,638 — SUMMARY Staphylococcus aureus and Bacillus anthracis are pathogenic members of the order Bacillales that each represent a considerable threat to global public health. The rise of S. aureus strains resistant to all known antimicrobials has the potential to eliminate available treatment options wherea…
FANG-TSYR LIN · BAYLOR COLLEGE OF MEDICINE · 2024 · $347,701 — Project Summary/Abstract The objective of this project is to characterize a new therapeutic target in order to improve breast cancer therapy by preventing breast cancer from spreading and restoring the effectiveness of hormone therapy. While estrogen receptor (ER) is the most successful therapeutic …
Devan Marc Gomez · VANDERBILT UNIVERSITY · 2024 · $84,969 — DESCRIPTION (provided by applicant): Opioid abuse remains a costly epidemic in the US, prompting research into new and effective interventions to curb addiction-like behavior. Amongst the therapeutic characteristics of opioids, their associated withdrawal effects are substantial and recognized to…
Summer S Han · STANFORD UNIVERSITY · 2024 · $621,799 — Lung cancer (LC) is the leading cause of cancer deaths in the U.S. The widespread adoption of low dose computed tomography (LDCT) screening enables the early detection of LC and is expected to increase the number of long-term LC survivors. While recent studies show that LC survivors have a high risk…
Andrew C White · CORNELL UNIVERSITY · 2024 · $320,034 — PROJECT SUMMARY / ABSTRACT Melanocyte stem cells (McSCs) of the hair follicle can serve as a reservoir for melanocyte replenishment to the epidermal layer of the skin. This property has been demonstrated in patients with the depigmentation disease vitiligo, in which new pigmentation is found in a p…
Alexandra Freeman · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $423,120 — PROJECT SUMMARY/ABSTRACT Chronic suppurative respiratory disease is characterized by persistent and recurrent otitis media, sinusitis, bronchitis as well as bronchiectasis. Genetic etiologies include inborn errors of immunity (IEI) with defective cellular and antibody-mediated responses and disorder…
Alexander John Knights · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $103,080 — Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease that arises after injury and affects millions worldwide. There are currently no disease-modifying treatments. PTOA is a complex, multi-tissue joint disease characterized by pain, cartilage degradation, synovial inflammation and fib…
KIMBERLY D NARAIN · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $177,444 — Project Summary/Abstract This career development award will establish Dr. Kimberly Narain, MD, PhD, MPH, as an independent investigator focused on evaluating the health, aging and healthcare costs implications of social, economic and health policies/programs, among adults with low socioeconomic stat…
Ryohei Yasuda · MAX PLANCK FLORIDA CORPORATION · 2024 · $1,123,260 — Abstract Dendritic spines are mushroom-shaped postsynaptic compartments that host intracellular signaling cascades important for synaptic plasticity and, thereby, learning and memory. Signaling events in spines involve a network composed of hundreds of proteins interacting with each other extensivel…
Rana Rais · JOHNS HOPKINS UNIVERSITY · 2024 · $471,402 — The number of people suffering from Alzheimer's disease (AD) is steadily rising and current treatments only provide minor symptom amelioration. Results from recent clinical trials targeting amyloid-β (Aβ) production or clearance were disappointing, prompting a reexamination of approaches to AD treat…
William James Sheehan · CHILDREN'S RESEARCH INSTITUTE · 2024 · $432,791 — Leveraging our institution’s diverse and experienced investigator base, our success in leading collaborative and single-site randomized clinical trials (RCTs) and mechanistic and observational studies, and our access to a large population of urban, disadvantaged, and largely minority youth with asth…
OLIVER J RANDO · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2024 · $508,917 — Project Summary/Abstract Over the past century, a marked demographic shift in the United States and other wealthy countries has lead to childbearing occurring later and later in life. In addition to the decrease in fecundity that accompanies aging, there is accumulating evidence that paternal age ca…
Hongkuan Fan · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $377,539 — Project Summary: Sepsis affects more than 19 million people each year. With improved treatment strategies, more and more patients survive sepsis. The majority of these survivors develop cognitive impairment and mental health problems. However, the mechanisms that promote sepsis-associated encephalo…
Goutham Narla · UNIVERSITY OF IOWA · 2024 · $503,559 — Project Summary / Abstract Neuroendocrine tumors (NETs) are incurable, clinically challenging malignancies that are rising in incidence. Although tumors grow slowly, they progress relentlessly and lack effective therapies once they become metastatic. Many patients with advanced NETs will die from th…
Kayarat Saidas Nair · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $417,936 — ABSTRACT Glaucoma, a major cause of blindness worldwide, is a significant public health concern. In the U.S., it affects over 2.7 million people and its prevalence will rise to 7.3 million by 2050. Targeted therapies are needed to prevent glaucoma or slow its progression. A major risk factor is high…
William Adam Grobman · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $698,088 — ABSTRACT A growing number of studies has implicated maternal stress as an explanation for the higher burden of adverse pregnancy outcomes (APOs) seen among non-Hispanic Black women compared with their non-Hispanic White counterparts. Most studies that have explored the relationship between stress an…
Yangyang Wang · BRANDEIS UNIVERSITY · 2024 · $357,884 — PROJECT SUMMARY (See instructions): Overview: The preBotzinger Complex (preBotC) is the neuronal network that drives inspiratory rhythmogenesis whose activity is orchestrated in response to changes in homeostasis and is critical for maintaining and adapting breathing to the demands of the organism. …
Fengtian Xue · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $183,469 — PROJECT SUMMARY Alcohol use disorders (AUDs) represent a leading health issue that causes an enormous number of deaths and disabilities globally, highlighting the critical medical need for the development of novel therapeutic strategies. The Gao Lab recently showed that hepatocyte-specific Aldh2-def…
Erika Garcia · UNIVERSITY OF SOUTHERN CALIFORNIA · 2024 · $436,859 — PROJECT SUMMARY/ABSTRACT Electrification of the transportation sector in the United States, crucial for climate change mitigation, is projected to have considerable co-benefits for public health through reductions in tailpipe-related emission. Numerous studies have estimated impacts on air quality a…
Xin Ge · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $390,000 — PROJECT SUMMARY As important signaling molecules, proteases precisely control a wide variety of physiological processes both in health and in diseases, and thus represent one of the largest families of pharmaceutical targets. Despite decades of intensive efforts, conventional drug discovery strategi…