Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Andrew B Adams · UNIVERSITY OF MINNESOTA · 2024 · $3,635,295 — While short-term outcomes following organ transplant have greatly improved with the development of more effective immunosuppression, long-term outcomes remain problematic with a significant number of patients developing diabetes, accelerated heart disease as well as increased rates of cancers and in…
RICHARD LEIGH · JOHNS HOPKINS UNIVERSITY · 2024 · $621,691 — Project Summary/Abstract This study is focused on expanding our understanding of post-stroke cognitive impairment and dementia (PSCID). Studies have found that patients who suffer a stroke are at increased risk for developing subsequent cognitive decline. While this has been demonstrated epidemiolog…
CHARLES Michael COTTEN · DUKE UNIVERSITY · 2024 · $352,458 — Abstract The Duke University Division of Neonatology enthusiastically submits this renewal application for participation in the Eunice Kennedy Shriver NICHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). Duke is submitting the application in collaboration with the University of N…
Gordon Joseph Berman · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $518,289 — Project Summary Physiological processes such as aging must arise from activities and events spanning multiple time scales. Although important, the dynamics of these processes are difficult to measure and study. In multicellular model organisms for aging, the freely living nematode C. elegans is amo…
Ke Zhang · NORTHEASTERN UNIVERSITY · 2024 · $473,599 — Project Summary/Abstract Oligonucleotides face several biopharmaceutical difficulties, including stability and delivery issues as well as non-hybridization activities such as coagulopathy and unwanted activation of the immune system. We have developed a unique oligonucleotide delivery system, termed…
Hayley Beth Gershengorn · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $324,861 — ABSTRACT Healthcare quality is impacted by structure and organization. Approximately 6 million Americans are admitted to an intensive care unit (ICU) yearly and many require mechanical ventilation for acute respiratory failure. Understanding optimal ICU organization is essential to ensure high quali…
Yu-Hua Tseng · JOSLIN DIABETES CENTER · 2024 · $526,732 — Project Summary/Abstract Obesity is growing at epidemic rates worldwide and leads to a broad spectrum of other disorders, which collectively form metabolic syndrome. Central to these pathologies is the adipose tissue. In mammals, there are two functionally distinct types of fat: white adipose tissu…
Myra Helen Wyckoff · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $349,633 — PROJECT SUMMARY This proposal is a reapplication from the University of Texas Southwestern (UTSW) Medical Center to participate as a clinical center in the Eunice Kennedy Shriver NICHD Neonatal Research Network (NRN). Myra Wyckoff, MD became Principal Investigator (PI) in September 2013 and will rem…
Jian-Dong Li · GEORGIA STATE UNIVERSITY · 2024 · $460,120 — Mucin, a major protein component in mucus, plays a critical role in mucosal innate defense by providing a physical barrier and trapping pathogens for mucociliary clearance. If uncontrolled, excessive mucin production overwhelms mucociliary clearance and causes conductive hearing loss in otitis media…
Yijie Wang · MICHIGAN STATE UNIVERSITY · 2024 · $417,388 — Modified Abstract Section Perceived negative treatment based on one’s social characteristics is a key factor contributing to mental and physical health disparities. Yet, the impact of perceived negative treatment on behavioral health outcomes such as substance use (SU) is less clear, particularly i…
Danielle N. Gray-Singh · CLARK ATLANTA UNIVERSITY · 2024 · $357,082 — PROJECT SUMMARY The U-RISE Program at Clark Atlanta University (CAU) is designed to transition academically promising undergraduates spread across the breadth of STEM disciplines into doctoral programs in biomedical sciences. We recognize that millennial scientists will be expected to keep pace with…
Ning Quan · FLORIDA ATLANTIC UNIVERSITY · 2024 · $331,903 — Project Summary Neuroinflammation is a significant contributor to most CNS disorders including neurodegenerative diseases and psychological disorders. A hallmark of neuroinflammation is the increased expression of the proinflammatory cytokine interleukin-1 (IL-1) in the brain. How IL-1 causes neuro-…
Ravi Mangal Patel · EMORY UNIVERSITY · 2024 · $344,300 — ABSTRACT In this renewal application, we highlight the ability, commitment and strengths of Emory University to continue its more than 3 decades of participation in the Eunice Kennedy Shriver NICHD Multicenter Neonatal Research Network (NRN). As the largest metropolitan city in the US with a single …
John Kisiel · MAYO CLINIC ROCHESTER · 2024 · $383,325 — PROJECT SUMMARY/ABSTRACT: Gastrointestinal (GI) malignancies lead cancer deaths worldwide, killing ~3 million annually. In the U.S., only colorectal cancers (CRC) are screened. Other GI cancers are not screened due to lack of accurate tests or because prevalence is deemed too low for cost-effective …
Susan Schembre · GEORGETOWN UNIVERSITY · 2024 · $616,731 — ABSTRACT The excessive intake of saturated fat and added sugars has been identified as a leading cause of premature mortality among adults in the U.S. contributing to approximately 700,000 deaths each year. The 2015-2020 Dietary Guidelines for Americans recommend limiting these nutrients to <10% tot…
RANDY L BUCKNER · HARVARD UNIVERSITY · 2024 · $558,231 — PROJECT ABSTRACT/SUMMARY Alzheimer's disease and other forms of dementia affect over five million Americans. Alzheimer's disease begins with changes in the brain more than a decade before the disease can be diagnosed from memory and cognitive impairment in a clinic. The goal of this work is to prov…
KATHRIN M BERNT · CHILDREN'S HOSP OF PHILADELPHIA · 2024 · $416,556 — PROJECT SUMMARY High expression of the transcriptional co-activator Meningioma-1 (MN1) is common in AML, and associated with a poor prognosis. Forced expression of MN1 in murine hematopoietic progenitors induces an aggressive leukemia. We recently discovered that the primary interaction partner of M…
SIMON K WARFIELD · BOSTON CHILDREN'S HOSPITAL · 2024 · $369,580 — Machine learning (ML) is poised to enable faster and more accurate interpretation of medical images by augmenting the capabilities of experts. The cost and difficulty of generating expert quality labelled image data is the primary limitation preventing faster progress and deployment in more domains.…
ANDREW K. GODWIN · UNIVERSITY OF KANSAS MEDICAL CENTER · 2024 · $298,484 — PROJECT SUMMARY Ovarian cancer is a silent killer that strikes with few, if any, symptoms. By the time a woman knows she has it, the cancer is often advanced and the outlook grim. However, if epithelial ovarian cancer is caught early the prognosis for the patient is excellent. Developing non-invasiv…
Sydney Montesi · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $177,348 — Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Within IPF, however, there exists marked disease heterogeneity as some patients experience a rapidly progressive course while others experience prolonged periods of stability or stepwise declines triggered by disease …