Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Julia Elizabeth Winterrowd Price · NEMOURS CHILDREN'S HOSPITAL, DELAWARE · 2024 · $137,351 — PROJECT SUMMARY/ABSTRACT Type 1 diabetes (T1D) is one of the most prevalent pediatric chronic illnesses and requires a complex treatment regimen. Youth with T1D, particularly those from ethnic minority and lower income backgrounds, struggle to adhere to treatment demands; fewer than 30% achieve reco…
WILLIAM S TALBOT · STANFORD UNIVERSITY · 2024 · $531,319 — Glia are non-neuronal cells with diverse functions that range from forming the myelin sheath to defending the brain against infection. A major goal of our research is to use the powerful experimental advantages of zebrafish to discover new genes that are essential for the development and function of…
Vladimir R Muzykantov · UNIVERSITY OF PENNSYLVANIA · 2024 · $698,173 — Two pulmonary interfaces play the key role in respiratory infections, both bacterial and viral (e.g., COVID19). The invaders enter via external interface formed by airway and alveolar epithelial cells. The adjacent internal vascular interface formed by endothelial cells recruits and other host defen…
Sarki A. Abdulkadir · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $542,383 — ABSTRACT MYC oncoproteins (including c-MYC, L-MYC and N-MYC) play critical roles in the initiation, progression and recurrence of many human malignancies. Extensive studies indicate that MYC is required to maintain tumor cell survival and proliferation. We have recently used a novel approach that co…
ROBERT William SHAFER · STANFORD UNIVERSITY · 2024 · $713,086 — PROJECT SUMMARY HIV drug resistance (HIVDR) is a threat to the success of antiretroviral (ARV) therapy (ART) and a major barrier to the elimination of AIDS as a public health problem. Persons with HIV who develop virological failure (VF) during ART are at high risk of developing HIVDR and transmitti…
Lynn PULLIAM · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · 2024 · $559,096 — Cognitive impairment in chronic well-controlled HIV infection continues to affect from 30%-60% of individuals. Mechanisms are still unknown but probably associated with continued neuroinflammation. Biomarkers for cognitive impairment have been inconsistent although neuroimaging has emerged as a poss…
Dennis H Kim · BOSTON CHILDREN'S HOSPITAL · 2024 · $442,500 — Project Summary The long-term goals of our research program, which has been supported by NIGMS since 2007, has been to understand how host-microbe interactions influence the physiology and behavior of Caenorhabditis elegans, with the anticipation that studies of the simple animal host will provide i…
SHI-JIE CHEN · UNIVERSITY OF MISSOURI-COLUMBIA · 2024 · $496,674 — RNA molecules play fundamental roles in nearly all cellular processes at the level of gene expression and regulation. Not surprisingly, emerging biomedical advances such as precision medicine and synthetic biology all point to RNA as the central regulators and information carriers. Recently, realizi…
Brooks Casas · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2024 · $658,717 — PROJECT SUMMARY Much work in decision neuroscience has been predicated on the hypothesis that dopaminergic signaling plays a critical role in value representations and their updating, and recent work has linked abnormalities in such value representations to specific features of psychiatric illness (…
Tod Edward Kippin · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2024 · $595,697 — Summary. Our overarching goal is to render therapeutic drug monitoring as convenient and highly time resolved as the continuous glucose monitor has rendered the monitoring of blood sugar. The realization of this goal would transform many aspects of both biomedical research and clinical practice. It …
ANTONIETA LAVIN · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2024 · $127,086 — PROJECT SUMMARY/ABSTRACT This renewal application seeks support for our well-established research education program in substance use disorders to support undergraduate students pursuing short-term summer research experiences at the Medical University of South Carolina (MUSC). The goal is to develop …
Aaron F Straight · STANFORD UNIVERSITY · 2024 · $475,613 — PROJECT SUMMARY The goal of cancer immunotherapy is to awaken the body’s anti-tumoral immune response to fight against all cancers in all patients. Our lab recently identified a key mechanism by which cancer cells are detected by our innate immune system. We now know that cancer cells, with intrins…
Maggie Lam · UNIVERSITY OF COLORADO DENVER · 2024 · $388,750 — PROJECT SUMMARY Cardiac hypertrophy and failure involve a rewiring of gene expression through alternative splicing, but it remains unclear which splicing changes are relevant to disease development, and how splice variants affect protein function. Although many alternative transcript isoforms have b…
Jane Chung · VIRGINIA COMMONWEALTH UNIVERSITY · 2024 · $627,333 — PROJECT SUMMARY/ABSTRACT Markers of functional decline begin years before clinical symptoms of Alzheimer’s disease and related dementias (ADRD). It is essential to capture these functional changes as early as possible to intervene before symptoms arise to prevent further deterioration and loss of in…
Liangliang Hao · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $249,000 — Summary More than 90% of all cancer-related deaths are caused by metastasis, the spread of cancer from its origin. By the time most cancer metastases become clinically visible, the disease has progressed too far to benefit from early-stage interventions such as surgery or radiation. Thus, new appro…
TIMOTHY M FAN · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2024 · $484,753 — Project Summary This is a new MPI R01 proposal bringing together protein engineering for immunotherapy (Wittrup, MIT) with comparative oncology/veterinary medicine (Fan, UIUC) to test clinical strategies for combining radiotherapy with intratumoral cytokine administration/retention in pet dogs with …
Alan Gi-Lun Cheng · STANFORD UNIVERSITY · 2024 · $351,416 — Basic science, translational, and clinical research in Otolaryngology – Head and Neck Surgery is improving the way we diagnose and treat patients. A critical component of these research areas is the partnership among clinicians, clinician-scientists, and basic scientists. Herein, we propose to enhan…
Andrea Christine Chaikovsky · SLOAN-KETTERING INST CAN RESEARCH · 2024 · $101,390 — PROJECT SUMMARY As tumors progress, cancer cells acquire characteristics that allow them to adapt to various stresses. In fact, one of the best predictors of patient outcome is disease stage at the time of diagnosis, as advanced tumors are more aggressive and difficult to treat. However, the underly…
Julie Biteen · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $307,257 — Project Summary Molecular-scale interactions enable subcellular organization, but the current state-of-the-art does not include a generalizable method for measuring how molecules move and cooperate on the nanometer scale and in real time within the cell. This gap is particularly striking in bacteria…
Jack A DeHovitz · SUNY DOWNSTATE MEDICAL CENTER · 2024 · $298,309 — PROJECT SUMMARY/ABSTRACT The NYS International Training and Research Program (ITRP) of SUNY Downstate Health Sciences University (DHSU) proposes to renew its existing HIV Research Training Program in Kazakhstan (KZ) in collaboration with Asfendiyarov Kazakh National Medical University (KNMU) in Alma…