Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Tingting Yang · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $411,250 — Project Summary/Abstract The bestrophin proteins are a family of Ca2+-activated anion channels widely distributed from bacteria to mammals, with representatives in most metazoans including four in humans (Best1-4). They open in response to increases of intracellular Ca2+ to mediate the passive flow…
Yutong Zhao · OHIO STATE UNIVERSITY · 2024 · $523,559 — Abstract Excessive lung microvascular endothelial inflammation is a pathological hallmark of acute respiratory distress syndrome (ARDS). Upon inflammatory stimuli, lung endothelial cells (ECs) increase chemokine and adhesion molecule expression, such as IL-6, and intercellular adhesion molecule 1, …
Jianfeng Cai · UNIVERSITY OF SOUTH FLORIDA · 2024 · $373,750 — Antibiotic resistance has recently been identified as one of the three greatest threats facing mankind in the 21st century by World Health Organization. One promising approach to combat antibiotic resistance is to reinvesti- gate known antibiotics and design their derivatives, in the hope of identif…
Elizabeth Goldfarb · YALE UNIVERSITY · 2024 · $167,088 — PROJECT SUMMARY Excessive alcohol use presents a serious public health problem and increases risk for many preventable chronic diseases. The cognitive and neural mechanisms that promote this problematic drinking behavior, especially through alcohol-related memories, are not well understood. What peo…
REGINA Marie SULLIVAN · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2024 · $461,238 — DESCRIPTION (provided by applicant): Development is a period of neurobehavioral changes requiring immature organisms to exhibit behavioral flexibility to adapt to the world. A traditional view of development sees existing brain circuits becoming more complex to accommodate behavioral change. Wh…
JEFF J. SEKELSKY · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $544,786 — ABSTRACT Recombination is both a means to avoid genome instability and to process that generates genome instability. In meiosis, DNA double-strand breaks are repaired into crossovers that are essential for accurate segregation of homologous chromosomes; defects in this process result in sterility or…
MAI T DANG · WASHINGTON UNIVERSITY · 2024 · $238,140 — The goal of the proposed 5-year training program is to facilitate Dr. Mai Dang’s full transition to an independent physician scientist. Her work is focused on identifying novel ways to modulate the brain tumor immune microenvironment to improve treatment strategies for pediatric patients. She was re…
Yun Wei · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $178,200 — PROJECT SUMMARY / ABSTRACT Rhabdomyosarcomas (RMS) are the most common childhood soft-tissue sarcomas affecting hundreds of patients in the United States annually. Current standard treatments for rhabdomyosarcoma (RMS) patients include chemotherapy, surgery, and /or radiation. However, even with the…
Michael-Christopher Keogh · EPICYPHER, INC. · 2024 · $1,032,776 — PROJECT SUMMARY Gene expression is regulated by the complex molecular cross-talk between DNA methylation (DNAme) and other chromatin features: e.g. histone post-translational modifications (PTMs) and chromatin associated proteins (ChAPs; transcription factors and chromatin remodelers). Significantl…
Isaac Jonathan Krauss · BRANDEIS UNIVERSITY · 2024 · $203,125 — Project Summary/Abstract HIV broadly neutralizing antibodies (bnAbs) most commonly target the High Mannose Patch (HMP), a mannose-rich region of HIV Env in the vicinity of the V3 loop and the N332 glycan. HMP bnAbs (e.g., 2G12, PGT128, BG18) tend to recognize non-reducing-terminal Man1α-2Man moietie…
Meng Yin · MAYO CLINIC ROCHESTER · 2024 · $331,603 — Chronic liver disease (CLD) is a highly common cause of death due to the development of cirrhosis and consequential life-threatening portal hypertension (PHTN). Hepatic venous pressure gradient (HVPG) measurement is the gold standard to evaluate PHTN but not readily available in routine clinical set…
Debajyoti Ghosh · UNIVERSITY OF CINCINNATI · 2024 · $216,766 — Abstract The prevalence of atopic diseases such as atopic dermatitis (AD) and asthma are increasing at high rates that can't be explained by purely genetic etiology, indicating the roles of environmental exposures in increasing disease risk. Environmental exposures that alter the risk of allergic di…
Claudio Luis Ferre · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2024 · $330,000 — PROJECT SUMMARY Cerebral palsy is the most common pediatric movement disorder and is caused by damage to brain areas during development. Children with unilateral cerebral palsy (UCP), the most common form of cerebral palsy, have unilateral impairments that cause muscle weakness, poor coordination, a…
Kushang Patel · UNIVERSITY OF WASHINGTON · 2024 · $137,990 — ABSTRACT Injury and violence are leading causes of pediaric death and disability, contribute to health inequities, and minority groups are disproportionately affected. The Pediatric Injury and Violence Prevention Student Internship Training (INSIGHT) course is an innovative, interdisciplinary, and i…
April Jorge · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $174,960 — Candidate: April Jorge, MD is an Instructor in Medicine at Harvard Medical School (HMS) and an Assistant in Medicine in the Rheumatology Unit at Massachusetts General Hospital (MGH). After graduating from the University of Maryland magna cum laude, she received her MD from Georgetown University, and…
Or P. Gozani · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2024 · $612,325 — ABSTRACT Our overarching goal is to elucidate the mode of action of and evaluate the therapeutic potential of the epigenetic regulatory factor NSD3 in the regulation of lung squamous cell carcinoma (LUSC) pathogenesis. Lung cancer is the most common cause of cancer-related mortality in the United S…
John S. Luque · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · 2024 · $150,316 — Project Summary African Americans continue to experience disparities for colorectal cancer (CRC) incidence and deaths compared to other racial/ethnic groups in the US and adherence with evidence-based CRC screening recommendations can reduce these disparities. Advantages of stool-based CRC screening…
BRIAN P. CERESA · UNIVERSITY OF LOUISVILLE · 2024 · $50,012 — Project Summary/Abstract This is a renewal application for a T35 summer medical student training program in vision research with two Specific Aims: 1) To provide hands-on training in basic and clinical vision research to medical students in a structured mentored environment and 2) To provide an inte…
Ajay Gupta · WEILL MEDICAL COLL OF CORNELL UNIV · 2024 · $661,408 — Our main objective is to use quantitative susceptibility mapping (QSM) in establishing reliable noninvasive MRI for identification and risk stratification of unstable carotid atherosclerotic plaques. Currently, decisions about carotid revascularization to prevent stroke, such as carotid endarterecto…
Rebecca Kathryn McHugh · MCLEAN HOSPITAL · 2024 · $350,550 — Project Summary/Abstract The misuse of opioids has reached an epidemic level in the United States, with approximately 2 million people suffering from opioid use disorder and over 46,800 opioid overdose fatalities in 2019. Medication-based treatment for opioid use disorder—such as buprenorphine maint…