Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
CRYSTAL WILEY CENE · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $342,360 — ABSTRACT/SUMMARY There is a well-known gap between what we know can optimize health and healthcare and what happens in everyday practice. Implementation science (ImS) holds promise for generating new knowledge to close this gap. ImS is especially important for addressing health inequities which resu…
Anne Kristina Bozack · STANFORD UNIVERSITY · 2024 · $125,847 — SUMMARY In the United States, Native American communities face the greatest burden of chronic diseases among all ethnic groups and high rates of cardiovascular disease (CVD) incidence and mortality. Elevated disease risk may be in part attributed to arsenic in drinking water, which is a key environm…
Michael John Palladino · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $526,383 — Abstract/Project summary: TPI Df is a devastating untreatable childhood metabolic disease resulting in anemia, paralysis, irreversible brain damage and premature death. Numerous single amino acid substitutions in Triosephosphate Isomerase (TPI) are pathogenic and result in rapidly progressing multis…
Graeme L Conn · EMORY UNIVERSITY · 2024 · $267,847 — The challenge of drug-resistant microbes requires that a new generation of basic scientists be broadly trained and educated in a triad of equally important sub-disciplines of anti-infective research: i.) mechanisms of antimicrobial resistance (AMR); ii.) antimicrobial discovery and development; and …
Timothy Tun Hla · BOSTON CHILDREN'S HOSPITAL · 2024 · $475,344 — PROJECT SUMMARY Retinal vascular dysfunction leads to visual impairment and loss of vision, a phenomenon that occurs in retinopathy of prematurity (ROP), diabetic retinopathy (DR) and neovascular age-related macular degeneration (AMD). Injury of the retinal endothelial cell (REC) initiates a series …
Xiaoyong Bao · UNIVERSITY OF TEXAS MED BR GALVESTON · 2024 · $799,998 — PROJECT SUMMARY/ABSTRACT tRNA-derived RNA Fragments (tRFs), a newly discovered family of non-coding RNAs (ncRNAs), are emerging as essential disease biomarkers and regulators. Our recent publication demonstrated that tRFs are the most impacted small ncRNAs (sncRNAs) by Alzheimer's disease (AD) in th…
Troy Adam Roepke · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $409,883 — Project Summary Chronic exposure to stressful experiences can result in maladaptive affective states that yield behavioral disturbances in rodents and stress-related mood disorders in humans. Over the last decade, the neural circuits underlying these maladaptive effects of stress have become better …
Fernando E Boada · STANFORD UNIVERSITY · 2024 · $557,250 — PROJECT SUMMARY: This proposal is devoted to the development, clinical implementation and evaluation of a novel, methodology for generating brain sodium images of unparalleled resolution and signal-to-noise-ratio. This methodology is a result or recent developments in Bayesian image reconstruction a…
VINCENT M. ROTELLO · UNIVERSITY OF MASSACHUSETTS AMHERST · 2024 · $337,548 — Project Summary/Abstract Targeting of Bioorthogonal Chemotherapeutic Nanozymes to Tumor-Associated Macrophages In our proposed research we will use bioorthogonal chemistry to target tumor-associated macrophages (TAMs) in breast cancer, using bioorthogonal chemistry to turn them into ‘drug factory’ …
Deepika Mohan · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $594,828 — PROJECT ABSTRACT Injury is the leading cause of loss of independence among those over the age 65, resulting in over 3 million Emergency Department (ED) visits, 800,000 hospitalizations, and greater than $50 billion in costs each year. Guideline-concordant triage of trauma patients – rapid identifica…
SANG EUN LEE · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · 2024 · $310,000 — Project Summary Environmental pollutants and anti-cancer chemicals induce DNA–protein crosslinks (DPCs, also known as protein adducts) of topoisomerases and other proteins that obstruct almost every chromatin transaction and lead to mutations, genome instability and cell death if not removed quickly…
Robert Christopher Pierce · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $531,579 — Project Summary The focus of this research program, which has been NIH-funded since 2012, is the influence of paternal psychostimulant self-administration on the physiology and behavior of subsequent generations (i.e. offspring and grand-offspring) using rat models. Our work previously demonstrated …
Amir Kheradmand · JOHNS HOPKINS UNIVERSITY · 2024 · $149,880 — Spatial perception is based on various sensory inputs processed within a widely-distributed cerebral network. Cur- rently it is not known how these multisensory mechanisms and their contributions to spatial orientation are affected by aging. Clinical histories in elderly frequently entail experience…
Lucie Kalousova · VANDERBILT UNIVERSITY · 2024 · $122,850 — Project Summary Women are more likely to develop Alzheimer's disease and related dementias (ADRD) later in life. The gender disparity can be partially explained by sex-related biological differences and women's longer life expectancy. The remaining portion is ascribed to structural inequalities. Bui…
Rebecca DeBoer · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $269,653 — PROJECT SUMMARY/ABSTRACT The burden of cancer is rising in Africa and mortality rates are high. A majority (70-80%) of patients present at advanced stages, and cancer care incurs substantial financial costs for families and healthcare systems. Even for potentially curable patients, effective treatme…
Andrea L. Roberts · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $547,791 — Project Summary Children of women exposed to childhood abuse exhibit increased risk for a wide array of neurodevelopmental deficits, including elevated risk of anxiety, depression, and social problems. Our studies have found that these children had a more than three-fold higher risk of autism and 70…
JOHN P BILEZIKIAN · EMORY UNIVERSITY · 2024 · $537,126 — SUMMARY Primary hyperparathyroidism (PHPT) is a condition caused by the excessive secretion of parathyroid hormone (PTH) that can lead to aggressive bone loss, osteoporosis and increased risk of fractures. Intriguingly, PHPT is a heterogeneous disease where some patients go on to develop bone loss w…
Robert M Stroud · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $562,812 — This project seeks to determine how voltage sensing domains control ion channel gating, a process fundamental to all neuronal transmission, to control of endolysosomal delivery into cells, and recycling of membrane proteins out to the plasma membrane. The aim is to determine the motion that is broug…
Qing Nie · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $541,385 — RESEARCH SUMMARY Embryonic development involves the formation of functional organs comprised of many different cell types, which often originate from different locations. Thus cell migration and differentiation must be tightly coordinated, but are typically studied as independent processes. Here we …
Chelsea Thorsheim · UNIVERSITY OF PENNSYLVANIA · 2024 · $51,974 — Abstract Non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging public health risk. Approximately 35% of Americans have NAFLD, and if left untreated, NAFLD can progress to non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Although obesity and Type II diabetes ha…