Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
ALEXANDER D JOHNSON · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $727,285 — Project Summary/Abstract Candida albicans is one of the most prevalent fungal pathogen of humans and also a component of the human microbiome; it can cause superficial infections in normal humans and life-threatening systemic infections in immune compromised individuals. Our work seeks to understand…
CHARLES ROBERTS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2024 · $450,446 — Project Summary/Abstract: A role for SWI/SNF complexes in cancer was first suggested when SMARCB1 was identified as inactivated in virtually all malignant rhabdoid tumor (RT) cases, a highly aggressive pediatric cancer. It is now clear that mutations in genes encoding subunits of SWI/SNF (BAF) chro…
Joyce Jose · PENNSYLVANIA STATE UNIVERSITY, THE · 2024 · $794,303 — PROJECT SUMMARY Although primarily transmitted by mosquitoes, the Zika virus (ZIKV) has the unique ability among flaviviruses to be transmitted horizontally through sexual contact, or vertically from mother to fetus. The vertical mode of transmission has led to devastating pregnancy and fetal develo…
JOANNE C CONOVER · UNIVERSITY OF CONNECTICUT STORRS · 2024 · $341,623 — Abstract Infections, both bacterial and viral, have been linked to pediatric hydrocephalus and can impact the nascent brain’s developmental programs. In fetal development, stem cells line the ventricles and provide neurons and glia required for brain development; ventricle-contacting stem cells also…
Ami Aalok Shah · JOHNS HOPKINS UNIVERSITY · 2024 · $169,411 — PROJECT SUMMARY / ABSTRACT This is a proposal for a K24 Midcareer Investigator Award in Patient-Oriented Research for Ami A. Shah, MD, MHS of Johns Hopkins University School of Medicine. Dr. Shah is an Associate Professor of Medicine in the Division of Rheumatology, Deputy Director for the Rheumatol…
MIRJANA MALETIC-SAVATIC · BOSTON CHILDREN'S HOSPITAL · 2024 · $832,810 — Project Summary/Abstract Copy number variations (CNVs) of the human 16p11.2 genetic locus, containing 29 coding genes, are associated with a number of neurodevelopmental and psychiatric disorders. The deletion (16pdel) and duplication (16pdup) variants of this region have poorly understood pleiotrop…
Asher Jefferson Albertson · WASHINGTON UNIVERSITY · 2024 · $198,676 — The goal of this mentored career development award is to facilitate the candidate’s transition to independence as a physician-scientist studying the molecular and neuronal mechanisms of stroke recovery. The candidate is an MD/PhD neurologist with a background in synaptic physiology and cortical netw…
Jarett D Berry · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · 2024 · $114,873 — PROJECT SUMMARY (30 lines) Dr. Jarett Berry is a Professor of Medicine in the Division of Cardiology at UT Southwestern Medical Center. Over the last 13+ years, he has led a successful program of research that has been supported through sustained funding from the NIH and/or the American Heart Assoca…
THOMAS A. RANDO · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2024 · $442,931 — PROJECT SUMMARY Current ideas that systemic factors regulate the aging of cells and tissues, in terms of both promoting and reversing the aging process, have emerged from studies of heterochronic parabiosis (HP) and heterochronic blood exchange (HBE) protocols. Our lab performed the first HP studie…
Nidhi Bhutani · STANFORD UNIVERSITY · 2024 · $516,747 — Abstract Although multiple pathways and targets have been proposed for OA treatment, the rate of drug failure in clinical trials has been astoundingly high. The reasons for the limited success include the late detection of the disease and a lack of understanding of the molecular heterogeneity betwee…
Marie Camerota · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · 2024 · $189,464 — PROJECT SUMMARY/ABSTRACT This K01 proposal will prepare the candidate for an independent research career studying environmental and biological contributors to child neurodevelopmental trajectories in typically-developing and high-risk populations, with specific expertise in human developmental behav…
MARIA JALBRZIKOWSKI · BOSTON CHILDREN'S HOSPITAL · 2024 · $773,425 — Project Summary/Abstract Converging lines of evidence support the hypothesis that deviations from typical brain structure development take place prior to psychosis onset, while ‘big data’ neuroimaging studies of adults with psychosis find subtle, widespread gray matter disruptions in the brain. In t…
Katja Gabriele Weinacht · STANFORD UNIVERSITY · 2024 · $573,075 — PROJECT SUMMARY/ABSTRACT Cellular ATP demand and mitochondrial ATP synthesis are tightly linked. ATP synthesis, in turn, depends on (1) NADH generation in the TCA cycle and (2) recycling of the adenine nucleotide pool. When ATP is depleted and AMP rises, the cell increases energy generation and curt…
Pascal Simon Kaeser · HARVARD MEDICAL SCHOOL · 2024 · $581,175 — Summary Many central neurons release neuromodulatory transmitters, for example monoamines, neuropeptides, and neurotrophins, from their somata and dendrites. Release of these transmitters is followed by G-protein coupled receptor activation, and these neuromodulator pathways are essential for brain …
FREDERICK D QUINN · UNIVERSITY OF GEORGIA · 2024 · $461,920 — Summary Bacterial and viral respiratory pathogens interact closely with mucosal surfaces. Specialized innate and adaptive mucosal immune systems protect these surfaces and are the first line of defense for the body. One of the more important reasons for the development of mucosal vaccines is the inc…
Eric A Galburt · WASHINGTON UNIVERSITY · 2024 · $466,500 — PROJECT SUMMARY/ABSTRACT This application describes our research into essential molecular pathways of the human pathogen, Mycobacterium tuberculosis (Mtb), including studies of transcription regulation and DNA repair. Infection with Mtb results in over 10 million new cases of tuberculosis and 1.5 m…
Andrew J Putnam · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $494,906 — Vascularization is of critical importance to the treatment of numerous pathologies and the success of tissue engineering. Many cell-based strategies to promote therapeutic vascularization have been explored in both pre-clinical models and clinical trials. However, approaches involving delivery of a …
Diana Montserrat Sheehan · FLORIDA INTERNATIONAL UNIVERSITY · 2024 · $544,510 — PROJECT SUMMARY Approximately 40% of Latino MSM with HIV do not achieve viral suppression—an estimate that has likely worsened due to COVID-19 Pandemic stressors such as unemployment, loss of health insurance, homelessness, and exacerbated mental health and substance use disorders caused by the COVI…
Gerard Arino Estrada · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $639,809 — Summary Time-of-flight positron emission tomography is a very effective nuclear imaging modality for the diagnosis and staging of a range of pathologies such as cancer, cardiovascular diseases, or musculoskeletal disorders. Commercial TOF-PET scanners currently employ lutetium-(yttrium)-oxyorthosili…
Sarah Ashley Helseth · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $188,705 — PROJECT SUMMARY/ABSTRACT Through the research and training described in this K23 proposal, the PI (Dr. Helseth) will acquire the necessary skills to become an independent clinical researcher focused on designing and evaluating early, substance use (SU) interventions for youth on risky developmental…