Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jiandie D Lin · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $510,001 — Project Summary/Abstract The obesity epidemic has increased the prevalence of non-alcoholic fatty liver disease, which ranges from clinically benign hepatic steatosis to non-alcoholic steatohepatitis (NASH). The latter represents a more severe disease state featured by the presence of chronic liver …
Vanessa Anne Leone · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $145,218 — PROJECT SUMMARY Metabolic diseases are increasing worldwide in prevalence and severity. Globally, approximately 650 million people are obese or overweight, over half of whom are children. The healthcare burden of obesity is enormous and only growing. Circadian rhythms play a central role in healthy …
William W Brey · FLORIDA STATE UNIVERSITY · 2024 · $1,052,841 — Nuclear magnetic resonance (NMR) spectroscopy is a unique set of experimental tools for understanding the intricacies of biology, from macromolecular complexes to complex mixtures, from atomic resolution structure to dynamics on timescales of picoseconds to seconds, from chemistry to functional mech…
Jareen Meinzen-Derr · MAYO CLINIC ARIZONA · 2024 · $40,000 — Project Abstract This proposal requests support for the next five Society of Ear, Nose and Throat Advances in Children (SENTAC) annual scientific conferences, to enhance diversity, equity, and inclusion. The 51st SENTAC (2023; 1st year of support) will be held at the Medical University of South Caro…
Anice C Lowen · EMORY UNIVERSITY · 2024 · $189,353 — Summary The central role of the interferon (IFN) cytokines in innate antiviral responses has been recognized for decades and many of the mechanisms underlying their induction and the responses they trigger have been worked out in molecular detail. Much less well-understood, however, is the impact of…
Sarah Ann Thomas · EMMA PENDLETON BRADLEY HOSPITAL · 2024 · $196,776 — 7. PROJECT SUMMARY: Cannabis use (CU) initiated in adolescence is associated with substantial consequences, from cognitive decline to addiction. While CU may disrupt normal processes of adolescent brain development, relatively little is known about how adolescent CU disrupts circuits mediating cogni…
Joel Adam Butterwick · YALE UNIVERSITY · 2024 · $353,319 — PROJECT SUMMARY Animals desire sugars for their energy potential and for the pleasurable sensation of tasting sweetness. Despite the importance of sugar receptors in influencing nutrient sensing, metabolic responses, and taste perception, few studies have been performed to identify the molecular mec…
Scott K Heysell · UNIVERSITY OF VIRGINIA · 2024 · $785,512 — PROJECT SUMMARY/ABSTRACT Tuberculosis (TB) is a major cause of morbidity and mortality worldwide with most deaths occurring in individuals infected with highly treatable, drug sensitive stains. Individual pharmacokinetic variability is an important driver of TB treatment failure particularly among u…
Evangelos A Christou · UNIVERSITY OF FLORIDA · 2024 · $369,915 — PROJECT SUMMARY Essential voice tremor (EVT) affects over 40% of individuals with essential tremor (ET), one of the most common movement disorders. While ET is characterized primarily by upper limb tremor, EVT is a significant problem because it profoundly disturbs communication and quality of life.…
David J Friedman · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $540,299 — SUMMARY: Two ancestry-associated coding variants in APOL1 drive much of the racial disparity in rates of kidney disease. However, the presence of two risk alleles (a high-risk genotype) does not lead to kidney disease in all or even most individuals, indicating that other factors must also be import…
Robert John Wessells · WAYNE STATE UNIVERSITY · 2024 · $441,380 — Project Summary Endurance exercise is a highly effective intervention for ensuring healthy metabolism and maintaining healthy function during aging, but is unavailable to patients with illnesses or injuries that restrict their movement. Here, we follow up on previous discoveries from the fruit fly m…
Kanishka Thiran Jayasundera · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $695,936 — Abstract The distinct phenotypes making up inherited retinal degenerations (IRDs) affect all forms of functional vision, and therefore, provide an illustrative disease model for low vision and blindness. Usual care for individuals with IRDs consists of low vision rehabilitation (LVR). Patients exper…
Karen F Oegema · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $370,317 — PROJECT SUMMARY Centrosomes, the major microtubule organizing centers in animal cells, are duplicated precisely once per cell cycle to catalyze microtubule generation for rapid bipolar spindle assembly and ensure accurate chromosome segregation. Centrosome amplification and fragmentation are frequen…
Bettina Fries · NORTHPORT VA MEDICAL CENTER · 2024 — Optimization of therapeutic mAbs to carbapenem resistant Klebsiella clones Carbapenem resistant Klebsiella pneumoniae (CR-Kp) bacteria continue to be the most common gram- negative multidrug-resistant bacteria in US hospitals. CR-Kp cause predominantly pneumonia, sepsis, and urinary tract infections…
Sacoby Miguel Wilson · UNIV OF MARYLAND, COLLEGE PARK · 2024 · $693,384 — PROJECT SUMMARY. Across the state of Maryland, communities of color and low wealth populations are differentially burdened by environmental hazards and the cumulative impacts of chemical and non-chemical stressors and structural factors (including pathogenic infrastructure) that produce environmenta…
CRAIG P HERSH · JOHNS HOPKINS UNIVERSITY · 2024 · $675,739 — PROJECT SUMMARY Multiple lines of evidence point to the role of adaptive immunity as response to viral infections and/or as misdirected autoimmune response in subjects with COPD and emphysema. There is support for an association between adaptive immune responses and COPD progression, but a direct li…
Ali Pirasteh · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $683,258 — PROJECT SUMMARY/ABSTRACT The overall goal of this revised proposal is to address the important unmet need for noninvasive detection and assessment of liver fibrogenesis, the pathologic process resulting in liver scarring and fibrosis. Fibrosis is the cumulative end-result of all chronic liver disea…
ERIC M STICE · STANFORD UNIVERSITY · 2024 · $638,449 — ABSTRACT Obesity is the second leading cause of premature death. Consumption of ultra-processed foods is theorized to be a key cause of obesity. Ultra-processed foods are formulations of cheap industrial sources of dietary energy and nutrients plus additives such as fat, sugar, and flavors that enha…
Jacy Lee Wagnon · OHIO STATE UNIVERSITY · 2024 · $374,350 — PROJECT SUMMARY Developmental and epileptic encephalopathies (DEEs) are severe early-onset seizure disorders with treatment-resistant seizures, developmental delay/regression, and long-term cognitive and motor impairment. SCN8A DEE, caused by gain-of-function, missense variants in the voltage-gated …
Manmeet Ahluwalia · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $639,642 — ABSTRACT: Glioblastoma (GBM) has a complex infiltrating tumor microenvironment which extends well beyond the visible enhancing tumor margins and plays a substantial role in GBM recurrence and poor outcomes. Unfortunately, in the absence of a precise spatial map of tumor extent, it is often difficult…