Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
WILLIAM J LEHMAN · BOSTON UNIVERSITY MEDICAL CAMPUS · 2024 · $412,500 — Thin filament-linked actin-binding proteins, troponin and tropomyosin, control actomyosin-based muscle contraction in cardiac and skeletal muscles. To elucidate mechanisms of muscle thin filament function at a fundamental molecular level, it is crucial to determine the changing structural interactio…
Murali Mohan Yallapu · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2024 · $363,250 — The current SC01 application is aimed to develop a program that increase the research competitiveness of Dr. Yallapu at the University of Texas Rio Grande Valley (UTRGV). The UTRGV has historical mission and track record of training and graduating students from backgrounds underrepresented in biomed…
Paige Turner Johnson · UNIVERSITY OF ALABAMA IN TUSCALOOSA · 2024 · $256,878 — Project Summary/Abstract This innovative project will replicate the successful Health Sciences & Technology Academy from West Virginia, with important adaptations for our purposes, in rural Alabama (AL). This adaption will be called Health Sciences & Technology Academy-Alabama (HSTA-AL). The long-te…
LENORE M. MCWEY · FLORIDA STATE UNIVERSITY · 2024 · $154,000 — Project Summary/Abstract Child maltreatment is a serious problem in the U.S. and worldwide. An estimated 1 in 7 children are maltreated each year, and most recent annual U.S. data suggest that over 618,000 child maltreatment cases were substantiated. Approximately 30% of substantiated child and prot…
Sinem Beyhan · J. CRAIG VENTER INSTITUTE, INC. · 2024 · $97,500 — Project Summary Histoplasma capsulatum causes pulmonary and systemic infections in both healthy and immunocompromised individuals, and is the most common cause of fungal respiratory infections in healthy hosts. It is a dimorphic fungal pathogen that can sense and respond to human body temperature by…
WENYI FENG · UPSTATE MEDICAL UNIVERSITY · 2024 · $448,250 — PROJECT SUMMARY/ABSTRACT Common fragile sites (CFSs) are recurrent “wounds” in every person's genome that predispose the chromosomes to DNA double strand breaks (DSBs) and rearrangements. Known features associated with CFSs include late replication timing, which is further enhanced upon replication…
Gianna Elena Hammer · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $231,000 — ABSTRACT Mechanisms driving inflammation, and the possibilities for therapeutic intervention, have expanded dramatically since the discovery that the intestine is linked to inflammatory diseases involving non-intestinal organs. The processes and cell types underpinning this inter-organ link are poor…
ZHAOYANG YOU · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $230,240 — A Novel Vaccine Adjuvant KOR-selective Small Molecule Agonist ABSTRACT Discovering safe and effective adjuvants that are crucial for vaccine efficacy is a key challenge. The skin is an ideal accessible target for vaccination. Identifying clinical small molecules with potent adjuvant properties to en…
Karsten Bartels · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2024 · $330,829 — Abstract Alcohol consumption adversely affects up to 28% of hospitalized patients and contributes to a loss of 133 million disability-adjusted life years and 5.3% of worldwide deaths each year. As alcohol use has substantial health and economic impact, much attention has been directed toward the num…
Francis Young-In Lee · YALE UNIVERSITY · 2024 · $507,749 — Project Summary:This A1 proposal focuses on impaired pathological fracture healing in the presence of breast cancer cells, not on the entire complex sequence of cancer spread from the breast to bone. Metastatic cancer cells can settle in anywhere in the bone including bone marrow, cortical bone, or …
Wendy G. Lichtenthal · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $434,596 — PROJECT SUMMARY/ABSTRACT The pain of loss figures prominently for millions of Americans, and while the emotional toll of bereavement is well-recognized, resulting disruptions to social connection often go unnoticed and unaddressed. The proposed study examines ruptures to social connection following …
Victoria Baranov · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $245,421 — ABSTRACT Depressive and anxiety disorders are among the leading contributors to the global disease burden and are more common in women compared to men. Among women in low-resource contexts, such as low- and middle- income countries (LMICs), exposure to adversities (e.g., poverty, intimate partner vi…
Shahid Karim · UNIVERSITY OF SOUTHERN MISSISSIPPI · 2024 · $222,000 — Summary Tick-borne diseases, including Spotted Fever Group Rickettsiosis, are rising due to climatic changes and are predicted to increase. The increase in rickettsiosis is a significant threat to public health in the absence of preventive measures. Tick hemocytes (immune cells) are mammalian leukoc…
HARRY K.W. KIM · UT SOUTHWESTERN MEDICAL CENTER · 2024 · $551,739 — Project Summary Legg-Calvé-Perthes disease is a childhood ischemic osteonecrosis of the femoral head (ONFH) that affects 1 in 1200 children between the ages of 2 to 14. It is one of the most serious conditions affecting the pediatric hip as 50% of patients will develop debilitating osteoarthritis, s…
William Raymond Lagor · BAYLOR COLLEGE OF MEDICINE · 2024 · $547,307 — This is a competing renewal R01 application that seeks to develop new gene editing approaches to treat Familial Hypercholesterolemia (FH). FH is an autosomal dominant disease most often caused by loss-of-function mutations in the low density lipoprotein receptor (LDLR), the protein responsible for u…
Ole A Andreassen · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $429,207 — Project Summary Now in its 13th year, the Psychiatric Genomics Consortium is perhaps the most innovative and productive experiment in the history of psychiatry. The PGC unified the field and attracted a cadre of outstanding scientists (802 investigators from 157 institutions in 41 countries). PGC wo…
Kristen Kraemer · BETH ISRAEL DEACONESS MEDICAL CENTER · 2024 · $162,680 — PROJECT SUMMARY This K23 award will support the candidate’s training and development for an independent clinical research career focused on understanding mechanisms of mind-body exercise interventions to optimize them for health behavior promotion in medical populations. BACKGROUND. Rates of physica…
Alexandre Y. Dombrovski · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2024 · $773,606 — This competing continuation proposal extends and deepens a productive program of longitudinal research on suicidal behavior in a cohort of 303 people with borderline personality disorder (BPD) with a prospectively ascertained high risk for serious suicide attempts. Our studies in 2017-22 focused on …
Mark M Walton · UNIVERSITY OF WASHINGTON · 2024 · $748,230 — ABSTRACT For more than 100 years much of oculomotor research in primates has been guided by Hering's law, which states that any eye movement generated by the brain will be sent equally to the two eyes so that they move as a yoked pair. Refixations between targets in different directions involve sac…
Adam C Miller · UNIVERSITY OF OREGON · 2024 · $587,222 — PROJECT SUMMARY All of brain function, from sensory perception to behavior, is derived from the pattern and properties of the synaptic connections among billions (in humans) of individual neurons. The long-term goal of this project is to understand molecular pathways that regulate electrical synapse…