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9873 documents

COVID-19 Clinical Support and Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Adrian McDermott · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $4,108,341 — In March 2020 the VIP began working in collaboration with VRC laboratories on the trial readouts for the Phase 1 DIMID 20-003 trial. The VIPs original focus was on the standard ELISA automated assay developing the readout for the SARS COV-2 S2P, RBD and N proteins. Pseudovirus neutralization was inc…

Project 1 Viral Genomics: surveillance, epidemiology, host response, and viral immunogenicity

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Pardis Christine Sabeti · BROAD INSTITUTE, INC. · 2020 · $349,995 — This proposal is intended to develop novel clinical diagnostics for, and increase our understanding of, the diversity, evolution, and spread of the newly emerged SARS-related coronavirus 2 (SARS-CoV-2) and other respiratory disease-causing pathogens in the United States. Coronavirus Disease 2019 (CO…

ConProject-001

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Mitchel A Rosen · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $11,163 — Abstract The New Jersey / New York Hazardous Materials Worker Training Center will provide training for essential works to respond and work safely when faced with exposure to COVID-19. The Center will provide train-the-trainer course via distance web conferencing to expand the knowledge of trainers …

Molecular Allergy

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Geoffrey Mueller · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $666,036 — I. Origins of Allergic Disease Over 100 million people worldwide suffer from birch pollen allergy. However, identification of molecular determinants driving the allergic responses to Bet v 1, the major birch pollen allergen, remains elusive. In collaboration with a group in Salzburg, Austria, we ex…

NIEHS Cryo-EM Core Facility

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Mario Borgnia · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $2,904,674 — During FY2020, the Cryo-EM Core continued to collaborate with regional researchers through the Molecular Microscopy Consortium. The high productivity of the past year is reflected in the number of publications that resulted from over two dozen collaborations. This year we had our first Regional Symp…

Immunoengineering

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Kaitlyn Sadtler · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2020 · $917,000 — Utilization of High-Color Flow Cytometry for Interrogation of Immune Activation and Polarization in Medical Device Development and Infectious Disease We have implemented the use of high-color flow cytometry on human samples and are currently designing antibody panels for mouse samples. Most antibod…

Program in Clinical Research, Clinical Support Services and Clinical Training

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Janet Hall · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $5,137,369 — The NIEHS Clinical Research Branch has continued to expand its scope of support for clinical and translational studies. The NIEHS Clinical Research Unit (CRU) has recorded over 11,000 patient encounters with over 95% patient satisfaction. Additional staff have been hired to support CRU functions. …

Mass Spectrometry Identification

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Jason Williams · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2020 · $720,964 — A variety of service and collaborative projects in protein identification have been or are being carried out within the Mass Spectrometry Research and Support Group with approximately 3000 samples analyzed from 31 scientists representing 23 principal investigators or core heads from 7 laboratory bra…

Target-based Assays and Screening Strategies for Chemical Probe and Therapeutic Lead Discovery

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

James Inglese · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · 2020 · $420,568 — This project includes the development of biochemical and target-focused assays based on specific protein or nucleic acid targets implicated in disease. The assay designs are considered in the context of analysis and progression strategies for evaluation of a wide range of compound classes using hi…

Host factors contributing to susceptibility to COVID-19 disease

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Helen Chun-Hui Su · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $5,003,232 — These studies have been organized as part of a broader effort among multiple principal investigators in the Intramural Research Programs of NIAID, NIDCR, NCI, and NIAMS, as well as a research collaborative agreement with investigators at the American Genome Center/Uniformed Services University of th…

Asthma and Allergic Diseases Group

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Samuel Arbes · RHO FEDERAL SYSTEMS DIVISION, INC. · 2020 · $10,601,507 — PROJECT SUMMARY / ABSTRACT COVID-19, the infectious disease caused by SARS-CoV-2, is rapidly affecting humans around the globe. While initial epidemiological data have focused on cases that resulted in severe respiratory disease seen predominantly in adults, little information regarding the infecti…

HDPTP

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

DAVID TURCOTTE · UNIVERSITY OF MASSACHUSETTS LOWELL · 2020 · $45,259 — Program Summary/Abstract This is a supplemental proposal for a coronavirus and infectious disease response training program to be implemented by The New England Consortium-Civil Service Employees Association (TNEC-CSEA), a partnership between the University of Massachusetts Lowell (UML), four New En…

Hazmat Disaster Preparedness Training Program

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Mitchel A Rosen · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $33,051 — Abstract The New Jersey / New York Hazardous Materials Worker Training Center will provide training for essential works to respond and work safely when faced with exposure to COVID-19. The Center will provide train-the-trainer course via distance web conferencing to expand the knowledge of trainers …

Microfabrication for Biomedical Research

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

Nicole Y Morgan · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · 2020 · $1,100,263 — The use of microfabricated and microfluidic structures in biomedical research has been rapidly expanding in recent years, but many research applications of these devices require customization, and new applications typically require several design iterations for troubleshooting. In an effort to bring…

Administrative Core

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

David J Erle · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $99,855 — PROJECT SUMMARY/ABSTRACT COVID-19, the pandemic illness caused by the novel virus SARS-CoV-2, is a serious respiratory illness that has high infectivity and a mortality rate that varies from <1% to up to 20% depending on underlying risk factors. Indeed, disease severity varies markedly based on reco…

Endotypes: Mechanisms and Consequences for Airway Epithelium and Mucus

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

David J Erle · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $4,237,614 — PROJECT SUMMARY/ABSTRACT COVID-19, the pandemic illness caused by the novel virus SARS-CoV-2, is a serious respiratory illness that has high infectivity and a mortality rate that varies from <1% to up to 20% depending on underlying risk factors. Indeed, disease severity varies markedly based on reco…

STRUCTURAL GENOMICS CENTERS FOR INFECTIOUS DISEASES - SARS-CoV-2 RESEARCH

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

PETER MYLER · SEATTLE CHILDREN'S HOSPITAL · 2020 · $580,155 — The goal of the Structural Genomics Centers for Infectious Diseases is to apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins on the NIAID Category A-C priority pathogens list and organisms…

BPCA-PTN COVID-19 STUDIES

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

KANECIA ZIMMERMAN, MD · DUKE UNIVERSITY · 2020 · $5,000,000 — For the last 25 years the scientific community, including academia, the National Institutes of Health (NIH), the Food and Drug Administration (FDA) and the pharmaceutical industry have worked to improve the knowledge of medications used in children. The responsibility for the implementation and o…

MICROBIOLOGY AND INFECTIOUS DISEASES BIOLOGICAL RESEARCH REPOSITORY (MID BRR) - SARS-CoV-2

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

TIMOTHY STEDMAN · AMERICAN TYPE CULTURE COLLECTION · 2020 · $4,101,590 — This contract provides unique and quality-assured infectious reagents and resources to the scientific community for use in basic research and product development. The scope of this contract includes the acquisition, authentication, production, preservation, storage, and distribution of research and …

NONHUMAN PRIMATE CORE HUMORAL IMMUNOLOGY LABORATORY FOR AIDS VACCINE RESEARCH AND DEVELOPMENT (COVID-19)

NIH Pandemic-Era Grants · Pandemic Era Grants / 2020

ROB CAUDLE · DUKE UNIVERSITY · 2020 · $996,432 — The mission of the Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID) is to ensure an end to the human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) epidemic by supporting research that can lead to the development of therapies, vaccines, an…