Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
DANA M BRANTLEY-SIEDERS · VANDERBILT UNIVERSITY · 2021 · $617,228 — Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any gene of interest, but siRNA use in clinical oncology faces delivery barriers such as nuclease degradation, rapid renal cl…
Brianna Leilani Bourgeois · LSU HEALTH SCIENCES CENTER · 2021 · $37,889 — Abstract The primary purpose of this Ruth L. Kirschstein NRSA F30 application is to provide the groundwork that will prepare the applicant for an academic medical career. Much of the applicant’s career development will come from work in High Priority HIV/AIDS comorbidity-related research, and she wi…
Ryan Sowell · STRAND THERAPEUTICS INC · 2021 · $399,508 — PROJECT SUMMARY While major strides have been made in the development of therapies for melanoma, cases continue to rise, with more diagnoses occurring at an early stage where surgery is indicated for patients. However, even with standard of care anti-PD-1 adjuvant immunotherapy, patients still have …
Mats Ljungman · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2021 · $182,325 — ABSTRACT Chromosome rearrangements are common in cancers and typically occur early in carcinogenesis. They drive tumor development by altering the expression or function of oncogenes and tumor suppressor genes by copy number alterations, formation of oncogenic fusions or by alterations of DNA elemen…
Zhaoyang Liu · UNIVERSITY OF TEXAS AT AUSTIN · 2021 · $92,610 — Project Summary Osteoarthritis (OA) is the most common form of degenerative joint disease affecting millions of people worldwide and lead to a tremendous financial burden. Currently there are no disease modifying therapies available for OA, due to limited understanding of the genetic factors and pat…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2021 · $371,835 — Project Summary Scientists can create thousands of chemically distinct nanoparticles using a growing number of high throughput chemistries, but it is still difficult to test more than a few nanoparticles in vivo. The goal of this work is to substantially improve how lipid nanoparticles (LNPs) delive…
NIGEL W BUNNETT · NEW YORK UNIVERSITY · 2021 · $282,990 — PROJECT SUMMARY This proposal examines the mechanisms by which G protein-coupled receptors (GPCRs) signal pain. Chronic pain is a hallmark of disease, a side effect of therapy, and a major cause of suffering. Although GPCRs mediate all aspects of nociception and are major therapeutic targets, the me…
William H. Peranteau · CHILDREN'S HOSP OF PHILADELPHIA · 2021 · $737,588 — PROJECT SUMMARY Metabolic liver diseases are the second most common indication for a pediatric liver transplant. Hereditary tyrosinemia type I (HT1) is a metabolic liver disease that results from FAH gene mutations causing a deficiency in fumarylacetoacetate hydrolase (FAH), the last enzyme in the t…
THOMAS Elliott VAN DYKE · ADA FORSYTH INSTITUTE, INC. · 2021 · $463,125 — Project Summary Uncontrolled inflammation is a major impediment to tissue engineering, regeneration and reconstruction of both diseased and injured tissues resulting in further tissue injury, tissue scarring and fibrosis. Stem cell activity is disrupted by persistent signals promoting inflammation, …
Evan Alexander Scott · NORTHWESTERN UNIVERSITY · 2021 · $761,409 — PROJECT SUMMARY Subunit vaccines combine immunodominant protein or peptide antigens from pathogens with select adjuvants, aiming to provide a more scalable, reproducible, low cost and rapid alternative to attenuated vaccines that contain live pathogens. Unfortunately, current subunit vaccines lack …
Virender Kumar · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2021 · $105,638 — PROJECT SUMMARY This K01 application aims to promote the applicant's development to become a multi-disciplinarily trained and independent academic researcher. This application's collective strengths are defined in these 3 major areas: 1) Credentials: PI's application builds upon his productive trac…
Gregory J Dodge · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $34,281
Sangpil Yoon · UNIVERSITY OF NOTRE DAME · 2021 · $121,563 — Project Summary / Abstract Dr. Sangpil Yoon is a postdoctoral scholar at the Department of Biomedical Engineering at the University of Southern California (USC). He has developed an innovative technique for the intracellular delivery of macromolecules using high frequency ultrasound. Dr. Yoon is a p…
Ram I. Mahato · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2023 · $475,579 — PROJECT SUMMARY Medulloblastoma (MB) is the most common childhood brain tumor arising from the cerebellum. Many factors influence the proliferation, differentiation, and migration of cerebellar granular neuronal precursor (GNP). Among them, MDM2 is a major nexus between tumor suppressor TP53 and he…
WENKE FENG · TULANE UNIVERSITY OF LOUISIANA · 2023 · $519,780 — Numerous studies have reported the efficacy of probiotics for alcohol associated liver disease (ALD). This reflects a strong interest among the scientific and medical communities in identifying alternative or adjunctive approaches for ALD, for which there is no current effective or widely accepted t…
Fekadu Kassie · UNIVERSITY OF MINNESOTA · 2023 · $345,230 — PROJECT SUMMARY Lung cancer is the leading cause of cancer-related death in the United States. About 90% of lung cancer cases are associated with genetic/epigenetic changes induced by tobacco smoke (TS). Although all types of lung cells could be affected by TS, the effect on stem cells is particular…
Olga Gursky · BOSTON UNIVERSITY MEDICAL CAMPUS · 2023 · $441,646 — Abstract Aberrant lipoprotein metabolism is a hallmark of obesity that affects >40% of Americans. Obesity and its com- plications, including type-2 diabetes (T2D), cardiovascular, amyloid and severe viral diseases, are the leading causes of premature death. The ultimate goal of this research is to …
David E. Pleasure · UNIVERSITY OF CALIFORNIA AT DAVIS · 2023 · $423,939 — ABSTRACT Canavan disease is a rare genetic neurological disorder characterized by a vacuolar (spongiform) leukodystrophy caused by ASPA mutations that diminish brain aspartoacylase activity. Neonatal/infantile Canavan disease is the most common and most severe form of the condition. Affected infants…
Jyothi Unnikrishna Menon · UNIVERSITY OF RHODE ISLAND · 2023 · $287,372 — ABSTRACT Hepatocellular carcinoma (HCC), the fastest rising cause of cancer-related deaths worldwide with a 5-year survival of <20%, affects more than 41,000 individuals in the United States every year. Heavy alcohol consumption leading to fatty liver, hepatitis and cirrhosis has been identified as …
Rebecca Sara Cook · VANDERBILT UNIVERSITY · 2023 · $117,567 — Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any gene of interest, but siRNA use in clinical oncology faces delivery barriers such as nuclease degradation, rapid renal cl…