Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2022 · $330,629 — The primary function of OMICS Core is to provide members of the University of Louisville Alcohol Research Center (ULARC) with the expertise, resources, and facilities needed for metabolomic, proteomic, and bioinformatic analyses of biological samples collected to study nutrition, gut flora/intestina…
Huan Xie · TEXAS SOUTHERN UNIVERSITY · 2022 · $225,689 — PROJECT SUMMARY Prostate cancer (PCa) is the second leading cause of cancer death in the United States among men and it is more common in African American males. Despite initial good responses to androgen deprivation or anti- androgen drugs, tumors invariably recur and develop into lethal castration…
Yuchao Chen · WELLSIM BIOMEDICAL TECHNOLOGIES, INC. · 2022 · $749,646 — PROJECT SUMMARY / ABSTRACT Extracellular vesicles (EVs) are small lipid bilayer particles secreted by most cell types, which encapsulates biomolecules including lipids, proteins, and nucleic acids from cells of origin. Profiling of EV-derived biomarkers provides a promising approach for diagnosis of…
Yizhou Dong · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2022 · $223,497 — Project Summary Cell-specific drug delivery represents one of the most important research areas in the field of drug delivery. Particularly, there are formidable challenges for in vivo mRNA delivery. For example, therapeutic window for current delivery systems is relatively narrow. A large number o…
Bulent Ozpolat · METHODIST HOSPITAL RESEARCH INSTITUTE · 2022 · $377,538 — Project Summary Triple negative breast cancer (TNBC) has the worst prognosis and survival in all breast cancer subtypes with currently available standard therapies, representing an unmet therapeutic challenge. Significant heterogeneity (with six genetically defined subgroups) and a lack of FDA-appro…
Zheng-Yi Chen · MASSACHUSETTS EYE AND EAR INFIRMARY · 2022 · $1,639,716 — Project Summary and Relevance Application of genome editing based therapy requires efficient delivery of editing agents into disease-relevant tissues and cells. Identification of novel delivery materials targeting somatic cells will greatly facilitate the advance of editing based therapy strategies …
James F. Collins · UNIVERSITY OF FLORIDA · 2022 · $100,000 — Project Summary Iron is an essential nutrient for rats, mice, and humans, yet iron in excess is toxic. Iron deficiency (ID) and iron overload (IO) thus result in severe homeostatic perturbations. Since iron excretion is inefficient and unregulated, intestinal iron absorption dictates overall body ir…
Teri Wang Odom · NORTHWESTERN UNIVERSITY · 2022 · $197,282 — PROJECT SUMMARY This proposal aims to develop live-cell, multi-channel imaging tools that can visualize—continuously, and in real time—nanoparticle interactions with cellular components. We will focus on several different time windows, where early time periods will monitor nanoparticle-cell membran…
CRAIG J. MCCLAIN · UNIVERSITY OF LOUISVILLE · 2022 · $1,467,472 — The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to perform interdisciplinary collaborative research on the role of nutrition as a cofactor in alcohol induced organ injury and as a possible therapeutic intervention to prevent/treat thi…
Kathleen R Chirco · OREGON HEALTH & SCIENCE UNIVERSITY · 2022 · $89,524 — PROJECT SUMMARY/ABSTRACT As the leading cause of inherited retinal degeneration, retinitis pigmentosa (RP) affects about 1.5 million people worldwide. Bardet-Biedl syndrome (BBS) is the second most common causes of syndromic RP, and is characterized as an autosomal recessive ciliopathy with severe p…
Forrest M Kievit · UNIVERSITY OF NEBRASKA LINCOLN · 2022 · $437,232 — PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI) is the leading cause of disability and death in people under 45 with approximately 10 million new cases each year worldwide. The effects of TBI can be severe, including neurocognitive, physical, and psychosocial impairment. There remains a signi…
JAKE JINKUN CHEN · TUFTS UNIVERSITY BOSTON · 2022 · $621,496 — Patients with type 2 diabetes (T2D) have substantially higher incidence of bone disorders, including as much as a 64% greater risk of fracture as compared to those without T2D. High blood glucose levels adversely alter bone cell functions, causing decreased bone formation and delayed wound healing w…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2022 · $648,444 — ABSTRACT Inherited retinal dystrophies (IRDs) are a heterogenous group of orphan diseases, inherited in an autosomal dominant, recessive or X-linked pattern in addition to mitochondrial transmission, all leading to the loss of functional vision and often progressing to blindness. As a group, IRDs ar…
Elliot Chaikof · BETH ISRAEL DEACONESS MEDICAL CENTER · 2022 · $1,385,636 — Project Summary New in vivo delivery technologies are urgently needed that enable selective genome editing of somatic cells without the limitations of existing viral delivery systems or lipid nanoparticles. We propose to develop two complementary strategies. First, by tethering Cas9 and base editor…
VALERIE B GOUON-EVANS · BOSTON MEDICAL CENTER · 2022 · $536,021 — PROJECT SUMMARY Liver transplantation is currently the only treatment for acute and chronic liver failure. Given the shortage of donor livers, hepatocyte transplantation is considered a potential treatment for liver diseases and a bridge for patients awaiting liver transplantation, but its applicati…
Emre H. Brookes · UNIVERSITY OF MONTANA · 2022 · $293,074 — Project Summary/Abstract We propose to continue development and support for the UltraScan-III (US3) software suite and develop new code and methods to address challenging biomedical research questions that can be solved with the latest instruments available for analytical ultracentrifugation and at …
Ram I. Mahato · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2022 · $488,954 — PROJECT SUMMARY Medulloblastoma (MB) is the most common childhood brain tumor arising from the cerebellum. Many factors influence the proliferation, differentiation, and migration of cerebellar granular neuronal precursor (GNP). Among them, MDM2 is a major nexus between tumor suppressor TP53 and he…
Jacob Daggett Ramsey · UNIV OF NORTH CAROLINA CHAPEL HILL · 2022 · $39,772 — Abstract/Project Summary Polymeric micelles are powerful drug delivery vehicles with a promising future. There are currently no US Food and Drug Administration approved polymeric micelle formulations, but some have been approved by the European Medicines Agency and other international regulatory bod…
GREGORY W FARIS · NUMENTUS TECHNOLOGIES INC. · 2022 · $226,273 — PROJECT SUMMARY There is increasing recognition that extracellular vesicles (EVs)¾micrometer- or nanometer-sized lipid particles containing protein and nucleic acid cargoes (information)¾are highly promising for new diagnostics/prognostics and even have therapeutic value. There is, however, an unme…
Rebecca Sara Cook · VANDERBILT UNIVERSITY · 2022 · $553,948 — Cancer nano-formulations for delivery of small molecule drugs are limited by the ability to target only ~10% of the genome. RNAi molecules can, in theory, be designed against any gene of interest, but siRNA use in clinical oncology faces delivery barriers such as nuclease degradation, rapid renal cl…