Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Hideki Aihara · UNIVERSITY OF MINNESOTA · 2024 · $170,789 — Project summary Viruses are a major threat to human health. Our laboratory uses various structural biology techniques to dissect molecular mechanisms of how viruses replicate and invade the host cell or its genome. One area of our major interest is retroviral integration, a critical step in the life…
GARY B RUVKUN · MASSACHUSETTS GENERAL HOSPITAL · 2024 · $431,960 — Project Summary/Abstract: Our discovery that the NGLY1/PNG-1 deglycosylation enzyme mediates the protein editing of N- glycosylated asparagines to aspartic acid of the SKN-1A transcription factor to increase proteasomal capacity is highly relevant to protein aggregation diseases, such as Alzheimer’s…
Nicholas Stephanopoulos · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $290,947 — Project Summary Protein-protein interactions (PPIs) drive countless processes in biology. The ability to block these interactions with high specificity is crucial for probing the basic science of these processes, as well as for developing imaging agents or novel therapeutics. However, most tradition…
MARGARET A TITUS · UNIVERSITY OF MINNESOTA · 2024 · $83,758 — Administrative Supplement for Equipment - GM122917 Margaret A. Titus, PI Project Summary Cells migrating in tissues, including cancer cells, use filopodia to guide them through the 3D environment and increased formation of filopodia correlates strongly with the metastatic potential and invasiveness…
William E. Van Nostrand · UNIVERSITY OF RHODE ISLAND · 2024 · $196,875 — Although the pandemic phase of SARS-CoV-2 infections has diminished the disease remains highly endemic in the US population with current weekly hospitalizations from infection remaining in the thousands and significant morbidity. Further, there is always the risk that new SARS-CoV-2 variants may ari…
Chandan Guha · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2024 · $141,834 — Abstract Radiation-Induced Immune Dysfunction (RIID) is a critical component of both acute and delayed effects of radiation exposure, which causes a multi-organ failure (MOF) syndrome, operationally divided based upon timing of clinical manifestations, as acute radiation syndrome (ARS) and delayed e…
John YJ Shyy · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2024 · $652,773 — Project Summary Vascular endothelial cell (EC) metabolism is essential for functional endothelium, and maladapted energy use severely affects EC health. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy status and homeostatic function. Our preliminary studies showed that ener…
JEAN S BAUM · RUTGERS, THE STATE UNIV OF N.J. · 2024 · $33,060 — Abstract The overarching goal in this proposal is to understand how molecular motions and biophysical properties modulate protein interactions to promote normal homeostasis or pathological disease states. We investigate the relationship between protein dynamics and interactions in three contexts: 1)…
Ashley Abel · YALE UNIVERSITY · 2024 · $48,974 — Abstract: Nearly 60% of human conceptions are miscarried surrounding the window of implantation. During this stage within a week after fertilization, the pluripotent epiblast tissue of the embryo transforms into a polarized epithelium with a central lumen. The causes of significant pregnancy loss at…
Luis J Sigal · THOMAS JEFFERSON UNIVERSITY · 2024 · $708,737 — Summary CD8 T-cells recognize and kill virus-infected cells displaying at the cell surface short viral peptides bound to major histocompatibility (MHC) class I molecules (MHC-I). CD8 T-cells contribute to the clearance of many viral infections. After an infection subsides, an expanded population of…
Philip A Mudd · WASHINGTON UNIVERSITY · 2024 · $597,818 — ABSTRACT Neutralizing antibodies are critical for protection from infectious diseases. The lymph node (LN) germinal center (GC) is the site where B cells undergo antibody affinity maturation and develop into long-lived plasma cells – key events that are required for the development of highly effecti…
Sanja Arandjelovic · UNIVERSITY OF VIRGINIA · 2024 · $570,668 — UNDERSTANDING A MOLECULAR CASCADE THAT DRIVES NEUTROPHIL MEDIATED PATHOLOGY IN ARTHRITIS Rheumatoid arthritis (RA) is a frequent chronic disease of the synovial joints characterized by painful loss of mobility due to unrestrained inflammation and progressive bone erosion. Disease etiology is poorly…
Renren Wen · VERSITI BLOOD HEALTH, INC. · 2024 · $646,675 — Abstract COVID-19 severity/lethality is associated with a dysfunctional inflammatory immune response and a hyper- engagement of pathways driving hemostasis and thrombosis, but the link between the two manifestations is not understood. Compared to patients with mild symptoms, severe COVID-19 patients…
David Huw Davies · UNIVERSITY OF CALIFORNIA-IRVINE · 2024 · $576,184 — PROJECT SUMMARY/ABSTRACT In this proposal we will define molecular and cellular mechanisms of different combinations of known adjuvant components MPLA (a TL4 agonist), CpG (a TLR9 agonist), agonists of cGAS-STING and NOD1/2 pathways, and a squalene-in-water emulsion (AddaVAX™). Our overall Aim is to…
Naly Torres · COLORADO STATE UNIVERSITY · 2024 · $41,282 — PROJECT SUMMARY This proposal outlines a training program for independent scientist with a focus on mRNA localization using genetics and molecular biology. The research outlined in this proposal will develop a platform to evaluate local translation, a process of whose disruption results in many neur…
Jonathan W Yewdell · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $634,568 — We have generated Sleeping Beauty transposase vectors that drive expression of the SARS-CoV-2 receptor ACE2 and or protease TMPRSS2 in host cells and use these vectors to create permanent transfected lines of A549, 293FT, and BHK-21 cells. We have generated a recombinant vesicular stomatitis virus t…
Doreen Matthies · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $3,299,641 — (1) Structure and function of magnesium channel Mrs2 Mrs2 is the eukaryotic homolog of bacterial magnesium channel CorA. CorA forms a homo-pentameric channel which forms a symmetric closed state at normal to high concentrations of magnesium with magnesium binding sites between protomers as well as n…
JOHN H KEHRL · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $147,159 — Beta-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Our recent studies have focused on two SARS-CoV-2 encoded proteins, open reading frame (ORF) 3a and 8. Previous studies of SARS-CoV-1 identified O…
William Copeland · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · 2024 · $470,939 — During this fiscal year we continued to devote major effort to work aimed at applications of molecular dynamics and quantum mechanics/molecular mechanics simulations required to help support the computational chemistry and molecular modeling needs of NIEHS scientists. Some projects involved creatio…
ROBERT A SEDER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2024 · $845,146 — Over the past year we have focused on how mucosal vaccination influences immunity and protection against Omicron variants of concerned compared to conventional mRNA boosting. For these studies, NHP are immunized with mRNA 1273 as the standard primary vaccine and then boosted several months later wit…