Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Maolin Lu · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · 2024 · $372,500 — Research Abstract: The spike/fusion glycoproteins residing on the surface of human enveloped viruses are targets of immune response and are the focus of researchers developing vaccines and antiviral treatments. The conformational dynamics of spike proteins drive the entry of enveloped viruses into c…
KAREN G. ANTHONY · L2 DIAGNOSTICS, LLC · 2024 · $299,878 — ABSTRACT Malaria remains one of the deadliest infectious diseases. Although much progress has been made in the fight against malaria, a highly effective and durable vaccine is not available. New vaccine candidates and improved delivery strategies are urgently needed. We recently demonstrated that a …
Yicheng Tu · UNIVERSITY OF SOUTH FLORIDA · 2024 · $287,142 — Project Summary We will design and develop a molecular simulation data management system, we call P2DMS, to analyze large dis- tributed molecular dynamics (MD) simulation data. The salient features of the system include: (1) a push-based local query engine design that handles data in a batch process…
Jieqing Zhu · VERSITI BLOOD HEALTH, INC. · 2024 · $718,854 — SUMMARY – Integrins interact with their ligands to induce intracellular signals that mediate cellular activities such as cell adhesion, spreading, and migration, which are the essential cellular activities for the function of blood and endothelial cells. These signaling events are typically mediated…
Barton F. Haynes · DUKE UNIVERSITY · 2024 · $5,303,216 — Request to DAIDS to Manufacture a protein encoding CAP256.wk34.c80 OPT4 envelope for induction of V2 Apex bnAbs Induction of an effective HIV-1 vaccine is a global priority; yet, no HIV-1 vaccine regimen reproducibly elicits broadly neutralizing antibodies (bnAbs) in humans. The complex immunology u…
Joyce Sooyeon Kim · JOHNS HOPKINS UNIVERSITY · 2024 · $76,756 — PROJECT SUMMARY Activation of sensory nerves, in particular nociceptive C-fibers, is a feature of most respiratory viruses. Evidence of such activation is found in the classical consequences of C-fiber activation including sneezing, sore throat, coughing, and reflex secretions. As well as causing th…
Anne Moscona · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $714,282 — No vaccines or treatments for SARS-CoV-2 are yet available. A simple prophylactic antiviral strategy would protect naïve individuals from infection now. In the future, when vaccines should be available, a prophylactic antiviral will be essential for individuals who do not mount a suitable immune res…
Ernesto Guccione · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $350,358 — SUMMARY Long-term protection from viral infections is mediated by both the humoral and cellular immune pathways. Multiple Myeloma (MM) is the second most common hematological malignancy in the US and is characterized by clonal plasma cell production, resulting in immune suppression and recurrent ba…
Michael Schotsaert · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $264,250 — Abstract Respiratory viruses spread from host to host as they are shed from mucosal surfaces and can transmit through the air or via surface contact. Therefore, it is believed that the induction of a strong mucosal immune defense cannot only prevent from infection at the port of virus entry, but als…
Michael William Grunst · YALE UNIVERSITY · 2024 · $48,974 — PROJECT SUMMARY Variants of SARS-CoV-2 continue to emerge with mutations in Spike that cause increased resistance to monoclonal antibodies and vaccines. These variants underscore the need for more universal antiviral approaches, such as targeting conserved regions in Spike and utilizing more broadly…
FREDERICK R BLATTNER · DNASTAR, INC. · 2024 · $1,020,000 — Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicit cellular responses that treat or cure disease. Discovering therapeutic antibodies traditionally requires costly and labor- intensive, laboratory-based screening experiments. Computational approaches …
Dirk P Dittmer · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $233,250 — ABSTRACT Clinical virology is predicated on the workflow of analyzing small sample volumes (to minimize patient discomfort, storage, and fit legacy infrastructure) for a single analyte, i.e., virus, with utmost precision. The human virome project (HVP) does not share these restrictions. The HVP prio…
RAJENDAR K DEORA · OHIO STATE UNIVERSITY · 2024 · $769,833 — With the emergence of SARS-CoV-2 variants with mutations in the Spike protein, there remains an urgent need for vaccines that are both effective against variants and that generate long-lived mucosal immunity. Generation of durable cell-mediated and humoral immunity is critical for optimal naturally …
Irina Budunova · NORTHWESTERN UNIVERSITY AT CHICAGO · 2024 · $206,917 — COVID-19 continues to be a global catastrophe despite development of anti-SARS-CoV-2 vaccines. This is due to the worldwide limited vaccine availability, vaccination hesitancy, and the emergence of new variants of SARS- CoV-2. Moreover, there is a lack of complete knowledge about SARS-CoV-2 biology,…
Ali Hassan Ellebedy · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2024 · $2,494,973 — The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-last…
Paolo Cravedi · PALO ALTO VETERANS INSTIT FOR RESEARCH · 2024 · $197,333 — PROJECT SUMMARY / ABSTRACT Solid organ transplant recipients have increased morbidity and mortality in response to infection with SARS- CoV-2, the virus responsible for COVID19. While the general population has greatly benefited from the rapid development of several vaccines that are protective agai…
Nan-ping Peter Weng · NATIONAL INSTITUTE ON AGING · 2024 · $444,588 — A vast array of T cell receptors (TCRs) is generated during T cell development in the thymus through V(D)J recombination, which involves the rearrangement of multiple V, D, and J genes and the pairing of and chains. These diverse TCRs provide protection to the human body against a multitude of forei…
JOSHUA ZIMMERBERG · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2024 · $1,356,672 — The first project in this report focuses on PIP2, a minor component of the PM in mammalian cells (~1% of total lipid) yet as the most abundant polyphosphoinositide it plays an outsized role in cell function. PIP2 mediates many intracellular processes, such as endo- and exocytosis, actin cytoskeleton…
Barbara Rehermann · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2024 · $1,814,404 — Chronic HBV infection progresses through distinct phases often with flares in disease severity. Flares cannot be predicted, and their pathogenesis is unknown. Pregnancy represents an excellent model to study the role of immune responses in disease flares because flares occur predominantly in the thi…
Clare Michal Waterman · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2024 · $545,678 — Project: CDK-1-mediated phase dissolution of Tensin1 condensates contributes to focal adhesion disassembly at mitosis to relieve an integrin inactivation G2-M checkpoint. Personnel: Ana Pasapera, Hrishika Gogeni Goal: Test the hypothesis that mitotic cell rounding is mediated by reducing cell-ECM a…