Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Donna L. Farber · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $916,382 — Project Summary/Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), has exploded into a global pandemic causing significant loss of life, pronounced economic impact and significant long-term medical impacts which are still being char…
Beatrice H Hahn · UNIVERSITY OF PENNSYLVANIA · 2022 · $855,061 — PROJECT SUMMARY A central goal in HIV/AIDS vaccine research is the elicitation of broadly neutralizing antibodies (bNAbs). Here, we propose to leverage three recent discoveries from our groups to generate novel envelope (Env) immunogens that target the V1V2 region of the trimer…
EDWARD CHU · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2022 · $334,913 — Abstract It is now well-established that COVID-19 in patients with cancer carries a higher morbidity and mortality, especially in amongst patients with hematologic malignancies1, 2. Effective vaccines have been developed and authorized by the FDA to combat this pandemic3-5. However, emerging data su…
Genevieve Giny Fouda Amou ou · WEILL MEDICAL COLL OF CORNELL UNIV · 2022 · $762,710 — Abstract As of March 2021, SARS-CoV-2 has caused more than 50 million infections and 2 million deaths, constituting an unprecedented pandemic in the modern world. While infected individuals rapidly develop IgG responses against the viral Spike after infection, some studies have indicated that indivi…
carolina barillas-mury · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $1,907,206 — Innate Immune Memory in Mosquitoes A previous infection primes the Anopheles gambiae immune response and enhances the defense response to subsequent Plasmodium infections and reducing malaria transmission. Immune priming is mediated by the systemic release of a hemocyte differentiation factor (HDF)…
William Elkins · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $28,533 — IDPS continues to support ongoing the Vaccine Research Centers (VRC) COVID-19 studies in the establishment and continued advancement of pre-exposure and post-exposure treatment modality (i.e. vaccine) studies using the rhesus macaque animal model. As a result, IDPS personnel were co-authors on 7 dif…
RICHARD CHILDS · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · 2022 · $3,264,185 — Approximately 20 years ago, we initiated the first ever clinical trail investigating allogeneic stem cell transplantation in patients with treatment refractory metastatic renal cell carcinoma (RCC). Definitive evidence for an allogeneic graft-versus-RCC effect has been demonstrated with complete reg…
JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2022 · $2,359,432 — Project Summary The goal of this Center of Biomedical Research Excellence is to continue our efforts to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approa…
NANCY J SULLIVAN · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $824,638 — Structure-based design and protein engineering principles were applied to stabilize the fusion (F) protein in its prefusion trimeric conformation (pre-F) to improve expression and increase immunogenicity. We covalently linked the stabilized pre-F through trimerization domains at the C-terminus to th…
JOSHUA ZIMMERBERG · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2022 · $1,745,170 — We demonstrated, using four independent techniquesnegative stain TEM, flow cytometry, NTA, and cryo-EMthat PVs bearing the Delta variant spike or the closely related Delta sublineage Delta AY.4.2 spike aggregate, whereas PVs bearing other spike variants and Bald PVs do not aggregate. Since the PVs w…
Roger Keith Reeves · HARVARD UNIVERSITY · 2022 · $341,018 — PROJECT SUMMARY/ABSTRACT Advanced Lab Technologies Core (Core I) One of the greatest added values of the Harvard University (HU) CFAR has been accelerated member access to new and emerging technologies. Science is accelerated by changes in technology, and the evolution of flow cytometric, imaging an…
Masaru Kanekiyo · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $31,820,000 — Improvements in vaccines against influenza that increase potency, breadth and durability of protection would improve worldwide ability to combat seasonal influenza as well as emergence of new pandemic influenza virus. This study aims to develop new platforms and vaccination strategies against ever-c…
James L. Gulley · DIVISION OF BASIC SCIENCES - NCI · 2022 · $70,148 — Four CCR projects are currently supported by this Cancer Moonshot Bench to Beside and Back award: 1. TME informed NK cell therapy for pediatric sarcomas, led by Rosandra Kaplan (CCR) and Timothy Cripe (Nationwide Children's Hospital). The overall goal of this project is to develop natural killer (NK…
Ursula Buchholz · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $1,356,084 — We previously performed codon-pair deoptimization (CPD) of various open reading frames (ORFs) of RSV. This is done by rearranging codons of RSV open reading frames using computer algorithms and de novo gene synthesis to increase the content of normally underrepresented codon-pairs without changing a…
Jesus Valenzuela · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $2,287,790 — The accomplishments of the section are: 1. We demonstrated an association between humoral and cellular immune response to the sand fly salivary protein rLinB-13 and disease severity of tegumentary leishmaniasis. We have previously shown that seropositivity to rLinB-13, a salivary protein from Lutz…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2022 · $5,627,958 — Mammarenaviruses Introduction: Lassa virus (LASV) is an enveloped, bisegmented, ambisense RNA virus and the cause of Lassa fever (LF) in humans. The natural reservoir of LASV is a small peri-domestic rodent, Mastomys natalensis. LASV is found across sub-Saharan West Africa with Guinea, Sierra Leone,…
DEBORAH M HINTON · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2022 · $291,528 — Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. When BvgS is active, BvgA is phosphorylated (BvgAP), and virulence activated genes are expressed (the Bvg(+) mode). When B…
Gunilla Karlsson Hedestam · SCRIPPS RESEARCH INSTITUTE, THE · 2022 · $368,066 — Summary Circulating (tier 2) HIV-1 variants are highly resistant to antibody-mediated neutralization, making broadly effective vaccine design a major challenge. Encouragingly, work in our previous HIVRAD program demonstrated that Ab responses capable of cross-neutralizing multiple heterologous tier …
Barton F. Haynes · DUKE UNIVERSITY · 2022 · $495,441 — The Administrative Core will coordinate the scientific and administrative activities of this IPCAVD Program, ensuring that the Projects and Cores function well together. In particular, it will be responsible for managing the program's financial management, program management, and coordinating Projec…
Jordan L Meier · DIVISION OF BASIC SCIENCES - NCI · 2022 · $1,784,658 — The overarching goal of this project is to define how environmental cues that impact protein and nucleic acid-based signaling, including but not limited to the epigenetic regulation of gene expression, contribute to cancer development and progression. To facilitate these studies we ar…