Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
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JOSEPH M FOX · UNIVERSITY OF DELAWARE · 2023 · $2,399,995 — Project Summary The goal of this Center of Biomedical Research Excellence is to continue our efforts to develop molecular approaches for probing biology, to discover and apply new chemical biology tools for the study of biological pathways associated with disease, and to develop computational approa…
Paul Stephen Keim · NORTHERN ARIZONA UNIVERSITY · 2023 · $1,542,693 — OVERALL Section Title: Early in vivo expressed antigens and their role in virulence, immune response, and vaccines for coccidioidomycosis. SUMMARY Coccidioidomycosis, also known as Valley Fever (VF), is an important fungal disease caused by two different Coccidioides species that results in regional…
Laura Lynn Newcomb · CALIFORNIA STATE UNIV SAN BERNARDINO · 2023 · $110,250 — Influenza virus remains an unmet health issue. Although the virus is controlled with annual vaccines, these exhibit variable efficacy, and slow vaccine production means vaccines are not available during an emerging pandemic. Antivirals can stunt an influenza pandemic, but antivirals become ineffecti…
ROBERT A SEDER · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,056,433 — Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide. Intradermal (ID) vaccination with BCG has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission. We showed that the route and dose of BCG vaccination alters circ…
NANCY J SULLIVAN · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $18,581 — Structure-based design and protein engineering principles were applied to stabilize the fusion (F) protein in its prefusion trimeric conformation (pre-F) to improve expression and increase immunogenicity. We covalently linked the stabilized pre-F through trimerization domains at the C-terminus to th…
Rosemarie Mason · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $929,036 — For this study we developed and optimized a robust, high-throughput (384-well format) ELISA binding assay to quantify Nipah virus (NiV) pre-fusion (pre-F)- and glycoprotein (G)-specific serum antibody binding responses. We also developed and optimized a highly reproducible NiV lentivirus vector-base…
Jean M Peccoud · COLORADO STATE UNIVERSITY · 2023 · $207,716 — Project Summary The unprecedented speed of COVID-19 vaccine development has demonstrated the value of vaccine platforms. In particular, mRNA vaccines proved surprisingly successful at eliciting a strong immune response while having a remarkable safety profile considering the novelty of this system. …
Ken A Halvorsen · STATE UNIVERSITY OF NEW YORK AT ALBANY · 2023 · $430,375 — Project Summary Our vision is to develop, apply, and advance new technologies in the broad thematic program of the manipulation of nucleic acids. The research largely focuses on RNA-based applications, which is both driven and enhanced by our unique environment at The RNA Institute, enabling easy co…
TERRY L. SHEPPARD · KEYSTONE SYMPOSIA · 2023 · $7,500 — ABSTRACT Support is requested for a Keystone Symposia conference entitled RNA Modifications in Health and Disease, organized by Drs. Eric Miska, Ramesh S. Pillai and Eva Maria Novoa Pardo. The conference will be held in Banff, Canada from December 12-15, 2023. Chemical modifications of RNA nucleotid…
Roger Sciammas · UNIVERSITY OF CALIFORNIA-IRVINE · 2023 · $66,200 — Project summary: The vast majority of mammalian genes produce alternatively processed mRNAs through alternative splicing and alternative polyadenylation (APA). Different mRNA isoforms produced from the same gene can encode distinct proteins and/or they may be differentially regulated. Recent studies…
Roger L Shapiro · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2023 · $1,202,581 — Overall Project Summary/Abstract Antiretroviral treatment (ART) options for pregnant women and children living with HIV have fallen behind those for adults, reflecting the substantial research gap for modern ART regimens in these groups. Safety and efficacy studies of specific ART regimens in pregna…
Jarrod Mousa · FLORIDA STATE UNIVERSITY · 2023 · $629,209 — The goal of this research project is to further the development of a pan-Pneumovirus vaccine and to test our hypothesis that a chimeric Pneumovirus fusion (F) protein vaccine displaying immunodominant epitopes of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) will induce broad pr…
Heinrich Feldmann · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $2,115,203 — During FY23 the focus of DMTs work was on filoviruses and orthonairoviruses. Filoviruses: Infections with ebolaviruses and marburgviruses, family Filoviridae, cause Ebola (EVD) and Marburg virus disease (MVD), respectively, with high case fatality rates. In addition, there are other filovirus gene…
BARBARA K FELBER · DIVISION OF BASIC SCIENCES - NCI · 2023 · $851,991 — We have been studying the immune response of COVID-19 cohorts longitudinally to characterize the nature and longevity of immune response (Rosati M, Am J Hematol: 97:E3, 2022; Rosati Frontiers Immunol 12: 793953, 2021; Thomopoulos, Viruses 1:1844; 2021; Terpos, Eur J Intern Med, 89:87,2021; Pappa, Mi…
Boris Dominik Juelg · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2023 · $796,711 — Project 2: Summary While traditionally regarded as a generalized tolerogenic state, emerging data suggest that pregnancy is far from a simple anti-inflammatory shift but is characterized by dramatic shifts from inflammation to tolerance over the course of pregnancy, to accommodate changes in the …
Jinwei Zhang · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2023 · $2,136,574 — We have made significant progresses in all three branches of the project: (a) T-box riboswitches, (b) tRNA-like structures in lncRNAs, and (c) Nucleic acid recognition by antibodies. (a) To gain insights into the T-box structural dynamics before and during tRNA binding, we carried out SAXS, fluores…
James L. Gulley · DIVISION OF BASIC SCIENCES - NCI · 2023 · $124,779 — Four CCR projects are currently supported by this Cancer Moonshot Bench to Beside and Back award: 1. TME informed NK cell therapy for pediatric sarcomas, led by Rosandra Kaplan (CCR) and Timothy Cripe (Nationwide Children's Hospital). The overall goal of this project is to develop natural killer (NK…
Maureen Goodenow · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2023 · $1,400,080 — Over the past year, our research in MHHIS, NIAID has made progress in the following three projects: Project 1. HIV exposed uninfected (HEU) infants have pro-inflammatory bioprofiles that correlate with maternal bioprofiles and persist for at least six months. HEU infants have a higher rate of mor…
Richard Thomas Wyatt · SCRIPPS RESEARCH INSTITUTE, THE · 2023 · $503,260 — Summary Circulating (tier 2) HIV-1 variants are highly resistant to antibody-mediated neutralization, making broadly effective vaccine design a major challenge. Encouragingly, work in our previous HIVRAD program demonstrated that Ab responses capable of cross-neutralizing multiple heterologous ti…
Steven M Lipkin · WEILL MEDICAL COLL OF CORNELL UNIV · 2023 · $360,907 — Project 1: Project Summary/Abstract Lynch syndrome (LS) affects ~1.2 million Americans and predisposes them to colorectal cancer (CRC) and other malignancies. LS normal cells acquire somatic second mutations and become DNA mismatch repair deficient (MMRD). MMRD tumors have exceptionally high numb…