NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Catharine Fairbairn · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · 2024 · $525,929 — Alcohol’s ability to improve mood in the face of stress is among its most prized reinforcing properties, long held by researchers to be of critical importance for the understanding of the etiology of alcohol use disorder (AUD). Drinkers overwhelmingly report that the mood-enhancement they gain from …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
STAVROULA KOUSTENI · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $500,000 — Project Summary/Abstract In the last decade, significant efforts have been made to understand the development and complexity of Myelodysplastic syndromes (MDS), leading to the identification of recurrently mutated genes with well-defined clinical, prognostic, and therapeutic implications. However, t…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Deborah Hall Bennett · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $1,109,470 — Beginning in fall, 2016, the UC Davis pediatric cohort, ReCHARGE, was funded with the new Environmental Influences on Child Health Outcomes (ECHO) Consortium that encompassed close to 80 sites. Now in year 7 of ECHO Phase 1, UC Davis has enrolled ~900 children into ECHO from three neurodevelopmental…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
David Scott Auerbach · UPSTATE MEDICAL UNIVERSITY · 2024 · $208,340 — Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of death in epilepsy. Many SUDEP cases had genetic variants linked to cardiac arrhythmias, particularly Long QT Syndrome (LQTS). Our lab and others showed that LQT2 patients are at a >2-fold higher risk of epilepsy, compared to genotyp…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Terry Roemer · PROKARYOTICS, INC. · 2024 · $295,592 — Widespread azole resistance among Candida and Aspergillus spp. along with emerging echinocandin resistance in C. glabrata and C. auris raises the specter of untreatable multidrug resistant fungal infections, even as advances in medicine (cancer chemotherapy, organ transplant, premature infants, HIV/…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Shusheng Wang · TULANE UNIVERSITY OF LOUISIANA · 2024 · $435,204 — PROJECT SUMMARY Subretinal fibrosis underlies the end-stage pathogenesis of several retinal diseases including age- related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR). Fibrosis results from neovascularization or injuries and is part of the wound healing response characteriz…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Stacie McEntyre · COUPLET CARE, LLC · 2024 · $649,496 — Abstract - Couplet Care, LLC is developing the Couplet Care BassinetTM, a novel infant clinical bassinet designed to support safe implementation of skin-to-skin contact and rooming-in on postnatal units. Until recently, the standard of hospital care for healthy term newborns was to be observed and c…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PHILLIP L PALMBOS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2024 · $429,017 — Over 17,000 will die from bladder cancer in the U.S. this year. While most patients with noninvasive tumors are cured, most patients with muscle-invasive disease will develop metastases and die. Therefore, understanding and targeting the molecular driver(s) which facilitate this invasive switch is e…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Felicia Gomez · WASHINGTON UNIVERSITY · 2024 · $194,367 — Hodgkin lymphoma (HL) accounts for ten percent of all lymphomas in the western world and remains a substantial clinical problem. Relapsed and refractory (R/R) HL presents a particularly critical unmet clinical need because approximately 25% of HL patients will be refractory to the standard of care o…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
PAUL R SCHWOEBEL · UNIVERSITY OF NEW MEXICO · 2024 · $372,741 — PROJECT SUMMARY/ABSTRACT This grant application proposes to use the unique stationary Multi-X-ray-source Array (MXA) technology developed and applied to digital breast tomosynthesis (DBT) under our current R01 to: 1) significantly improve DBT image quality by extending the MXA technology to produce …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Neeta L Vora · UNIV OF NORTH CAROLINA CHAPEL HILL · 2024 · $633,886 — ABSTRACT Fetal brain abnormalities (FBA) are one of the most common prenatal sonographic abnormality detected and account for ~20% of birth defects posing a substantial burden on the health care system. FBA can be isolated or syndromic and have vast phenotypic heterogeneity. The paired approach of p…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Xingyun Qi · RUTGERS THE STATE UNIV OF NJ CAMDEN · 2024 · $391,354 — Abstract Cells in a multicellular organism constantly communicate by ligand-receptor-mediated signaling to coordinate their growth, development, and adaptation to the environment. The peptide ligands-triggered signaling is the most abundant in this network in humans, dysregulation of which contribu…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Laura Bracaglia · VILLANOVA UNIVERSITY · 2024 · $245,275 — Abstract Ischemia reperfusion injury (IRI) causes endothelial inflammation and microvascular rarefaction that leads to adverse kidney graft outcomes in organ transplant. Direct treatment of endothelial cells (EC) can reduce the impact of IRI on the health of the graft, but there is a lack of EC targ…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JOHN GREENLAND · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $602,118 — The major barrier to long term survival following lung transplantation is a progressive loss of lung function, termed chronic lung allograft dysfunction (CLAD), for which constrictive fibrosis in small airways is a pathologic hallmark. CLAD affects over half of lung transplant recipients by 4 years …
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Lisa M Barroilhet · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $1,552,933 — ABSTRACT The need to provide safe and cost-effective measures to prevent Cancer is self-explanatory. The University of Wisconsin (UWISC) as the Lead Academic Organization (LAO) together with our collaborating institutions (Affiliated Organizations/AOs) propose to continue performing early phase canc…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
LEO BELETSKY · JOHNS HOPKINS UNIVERSITY · 2024 · $900,881 — The overall goal of this two-phase (R61/R33) study is to build capacity in the behavioral health workforce, consisting primarily of medications for opioid use disorder (MOUD) staff, by training them to deliver an evidence-based police education program to reduce HIV risk among people who use drugs (…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
TALAT Alp IKIZLER · VETERANS HEALTH ADMINISTRATION · 2024 — There are more than 420,000 patients receiving maintenance hemodialysis therapy in the United States, which is estimated to rise to over 500,000 patients by 2020. There are an estimated 45,500 veterans receiving hemodialysis, of which over 3,000 enrolled veterans were receiving dialysis at VA facili…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Manhattan E Charurat · UNIVERSITY OF MARYLAND BALTIMORE · 2024 · $699,789 — PROJECT ABSTRACT Tobacco use is highly prevalent among people living with HIV/AIDS (PLWH) especially in southern Africa where HIV is most heavily concentrated. Among PLWH, tobacco use impacts HIV-related co-morbidities and is the leading cause of premature mortality from non-HIV related malignancies…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
Bastiaan Driehuys · DUKE UNIVERSITY · 2024 · $736,853 — ABSTRACT The diagnosis and follow-up of patients with pulmonary arterial hypertension (PAH) continues to be challenging, with a lack of unambiguous biomarkers that reflect the course of the disease. PAH is characterized by pulmonary vascular remodeling with abnormal cellular proliferation and fibros…
NIH Pandemic-Era Grants
· Pandemic Era Grants
/ 2024
JARED M. RADBEL · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · 2024 · $222,505 — Project Summary/Abstract Acute respiratory distress syndrome (ARDS) develops in some individuals as a sequela to indirect stress on the lung from systemic infection (sepsis/endotoxemia). However, it is unclear why only some patients with sepsis develop ARDS. One possible risk factor leading to ARDS…