Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
SARAH A. WILLIAMS-BLANGERO · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · 2024 · $2,011,449 — PROJECT SUMMARY The University of Texas Rio Grande Valley seeks to establish a Diversity Center for Genome Research that will build UTRGV’s genomics research capacity by 1) expanding genomic research capabilities and discoveries in two innovative research projects; and 2) enhancing the size and qual…
Victor G. Davila-Roman · WASHINGTON UNIVERSITY · 2024 · $955,765 — Project Summary/Abstract The foundation for cardiovascular health (CVH) is laid in early life by intergenerational interactions, passed from parent to child, that have long-lasting biological and behavioral consequences. Lifestyle interventions can promote CVH among mothers and their children over t…
Jayhun Lee · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2024 · $36,218 — PROJECT SUMMARY/ABSTRACT Despite the hostile environment of the bloodstream where the host immune system is highly active, schistosomes, parasitic flatworms that cause schistosomiasis that affects over 200 million individuals globally, have a remarkable ability to thrive inside the vasculature for o…
KELLIE L. K. TAMASHIRO · JOHNS HOPKINS UNIVERSITY · 2024 · $96,351 — Obesity continues to rise worldwide. Maternal obesity and consumption of high calorie diets continue to be public health concerns. The intrauterine and early postnatal environment provides support that is critical to the proper development and health of offspring. Maternal high fat (HF) diet consump…
Andres J Garcia · GEORGIA INSTITUTE OF TECHNOLOGY · 2024 · $82,702 — PROJECT SUMMARY Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β-cells of the pancreas are destroyed. T1D affects 3 million children and adults in the US with healthcare costs exceeding $15 billion. Standard therapy with exogenous insulin is burdensome, associated wit…
John Michael Stafford · VANDERBILT UNIVERSITY MEDICAL CENTER · 2024 · $83,238 — Obesity impairs glucose and lipid metabolism and increases the risk of coronary heart disease (CHD). Women with obesity have ~1/2 the risk of CHD as obese men. The risk of CHD goes up with menopause, but by mechanisms distinct from obese men. The protection conferred by estrogen signaling in females…
Samuel Klein · WASHINGTON UNIVERSITY · 2024 · $59,881 — Obesity is associated with an increased risk of serious metabolic abnormalities, such as type 2 diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Data obtained from studies conducted in humans and rodents have suggested that “metabolic inflexibility” is critically involved …
Masayuki Nigo · METHODIST HOSPITAL RESEARCH INSTITUTE · 2024 · $470,454 — Abstract: (30 lines) Vancomycin is one of the most commonly used antimicrobial drugs in inpatient settings. National guidelines recommend Bayesian models to monitor the therapeutic drug concentration of vancomycin, especially for methicillin-resistant Staphylococcus aureus (MRSA), to minimize drug t…
Rajan P. Kulkarni · OREGON HEALTH & SCIENCE UNIVERSITY · 2024 · $705,441 — Immune related adverse events (irAEs) secondary to checkpoint blockade inhibition (CBI) or other immune modulatory therapy for cancer, including head and neck cancers, are a significant problem given the increasing use of CBI and other immunomodulatory agents. It is therefore of critical importance …
Daniel C Link · WASHINGTON UNIVERSITY · 2024 · $2,109,864 — ABSTRACT The Washington University SPORE in Leukemia is a highly dynamic translational cancer research program that focuses specifically on leukemias and myelodysplastic syndromes (MDS). We have assembled an outstanding group of investigators with complementary expertise in basic and clinical leukem…
Abigail Benkert · DUKE UNIVERSITY · 2024 · $83,392 — Project Summary/Abstract Disruption of mitochondrial oxidative phosphorylation (OXPHOS) is associated with the development of biochemical alterations that typically affect tissues with a high energy demand, particularly skeletal and cardiac muscle. An inherited autosomal recessive skeletal myopathy …
Jagpreet Chhatwal · BAYLOR COLLEGE OF MEDICINE · 2024 · $433,960 — The Translational Research Center (TRC) includes a diverse team of clinical and translational researchers with a strong track record of working together to reduce hepatocellular cancer (HCC). The TRC uses data from a unique group of patients with cirrhosis who are being recruited from eight differen…
Chanita A. Hughes-Halbert · UNIVERSITY OF FLORIDA · 2024 · $1,002,053 — SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer he…
Effie W Petersdorf · FRED HUTCHINSON CANCER CENTER · 2024 · $421,457 — Project Summary The HLA system encoded on chr6p defines the hematopoietic-cell transplantation barrier. Complete and precise HLA allele matching of the transplant donor and patient is performed to mitigate the risks of graft rejection and graft-versus-host disease. These efforts have lowered transpl…
Gina Lynn Razidlo · MAYO CLINIC ROCHESTER · 2024 · $350,743 — Metastasis is the primary cause of cancer death, yet therapeutic strategies to inhibit metastatic invasion do not exist. The long-term goal of our research program is to define the molecular mechanisms driving metastatic invasion, with the goal of identifying novel therapeutic targets and strategies…
Joshua Alfaro · PHARMAIN CORPORATION · 2024 · $995,099 — Osteosarcoma (OSA) is the most common primary malignancy of bone in children and adolescents, accounting for approximately 5% of all childhood tumors (www.cancer.gov). Osteosarcoma occurs primarily in the long bones of the limbs, including most commonly the femur, tibia, and humerus1. The current st…
M. CELESTE SIMON · UNIVERSITY OF PENNSYLVANIA · 2024 · $921,582 — Project Summary Renal cell carcinoma is among the ten most prevalent malignances in the United States, exhibiting an increased incidence in both men and women since 2001. The most common kidney cancer subtype is “clear cell” renal cell carcinoma (ccRCC), which accounts for ~75% of all cases. For ear…
Jonathan J Miner · UNIVERSITY OF PENNSYLVANIA · 2024 · $795,004 — Project Abstract The goal of this proposal is to define the mechanisms of retinal vasculopathy with cerebral leukoencephalopathy (RVCL), an adult-onset vascular dementia associated with brain atrophy, blindness, and premature death, usually within 5-10 years of disease onset. RVCL is an autosomal do…
Lisa Ann Lewis · PLANET BIOTECHNOLOGY, INC. · 2024 · $300,000 — ABSTRACT Gonorrhea affects over 87 million people annually globally. In 2021, over 700,000 cases of gonorrhea were reported to the CDC, a 118% increase since the historic low in the US in 2009. However, the true incidence of cases annually in the US is estimated to be ~1.5 million. The spread of ant…
JONATHAN C HORTON · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $209,893 — Project Summary Approximately 2% of children in the United States have strabismus, a condition in which the eyes are not aligned properly. As a consequence, stereovision may be lost and the deviated eye is at risk for reduced vision from amblyopia. There are many other potential consequences, inclu…