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Principal Investigator: Chanita A. Hughes-Halbert
Organization: UNIVERSITY OF FLORIDA
Fiscal Year: 2024
Award: $1,002,053
Funding agency: National Cancer Institute
SUMMARY – OVERALL COMPONENT
The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by
the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris
Comprehensive Cancer Center (USC-NCCC) to eliminate cancer health disparities in Florida, California and
nationally. The long term goals of the CaRE2 center are to reduce cancer disparities in Blacks and Latinos, to
train and increase the pool of underrepresented Black and Latino scientists conducting health disparity research,
to increase research capacity at FAMU, and to increase cancer disparity research at UF and USC-NCCC. The
bi-coastal location offers access to uniquely diverse populations of Blacks and Latinos, facilitating in an
unprecedented way, the study of cancer disparities in these incredibly heterogeneous populations. Specifically,
the center will focus on studying relevant issues and serving the needs of: (1) Black subpopulations, including
American-born, African-born and Caribbean-born Blacks; and (2) Latino subpopulations including Mexican-
Americans, Caribbean Latinos, Central and South Americans. This triad brings together investigators and
institutions in the two US states that currently have the highest cancer incidence and mortality. The main scientific
focus of the center is translational disparities research among heterogeneous minority populations focusing on
cancers known for high mortality. We propose to coalesce expertise, infrastructure and share resources in
support of 6 innovative translational research projects focused on understanding the biological basis of
disparities in Black and Latino populations, capturing the wide heterogeneity within these two groups, with two
foundational projects focusing on pancreas cancer (one full, one pilot) and one full project focusing on prostate
cancer (Aim 1). Under the leadership of the Research Education Core, we propose to train 100 Black and Latino
investigators, including students and early stage investigators (ESI), in translational cancer health disparity
research (Aim 2). Existing community partnerships in the Outreach Core will be leveraged to disseminate findings
in the Black and Latino community, educate about pancreas and prostate cancer, and improve participation in
biomedical research (Aim 3). Finally, the Planning and Evaluation Core will implement a systematic planning and
evaluation plan to improve Center effectiveness using innovative strategies (Aim 4). All research projects will be
facilitated and enriched by resources and approaches provided by the Tissue Modeling Core and Bioinformatics,
Statistical and Methodological Core. All CaRE2 Center’s activities will be centralized and overseen by the
Administrative Core. The FAMU-UF-USC partnership is ideally suited to achieve these aims. Both UF and FAMU
have worked closely together addressing cancer disparities in Florida Blacks for the last 4 years. USC-NCCC
provides complementary and synergistic expertise in cancer disparities research, research training for the Latino
population, and expertise in developing culturally-sensitive tools to reduce cancer disparities among Latinos.
Terms: <Address><Advocate><African><African American><Afro American><Afroamerican><American><Award><Back><Benchmarking><Best Practice Analysis><Bio-Informatics><Bioinformatics><Biologic Models><Biological><Biological Models><Biomedical Research><Black><Black American><Black Populations><Black group><Black individual><Black people><Black race><Blacks><California><Cancer Center><Cancer Control><Cancer Control Science><Cancer Model><Cancer Patient><CancerModel><Cancers><Caribbean><Caribbean Sea Region><Caribbean region><Caring><Catchment Area><Censuses><Central American><Chicanas><Chicanos><Communities><Community Outreach><Complex><Comprehensive Cancer Center><Cultural Diversity><Decrease disparity><Development><Disparities><Disparity><Doctor of Philosophy><Dorsum><EXTMR><Education><Education and Training><Educational Materials><Educational aspects><Effectiveness><Evaluation><Extramural><Extramural Activities><Florida><Fostering><Funding><Goals><Grant><Health><Health Disparities Research><Health disparities related research><Heterogeneity><Hispanic><Incidence><Individual><Individuals from minority><Individuals of minority><Infrastructure><Institution><Investigators><Latine><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Latinx><Latinx group><Latinx individual><Latinx people><Latinx population><Leadership><Location><Lower disparity><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Lung><Malignant Tumor of the Prostate><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Malignant neoplasm of prostate><Malignant prostatic tumor><Mentors><Methodology><Methods><Mexican Americans><Minority><Minority Groups><Minority People><Minority Population><Minority individual><Model System><Multiculturalism><Outcome><Pancreas Cancer><Pancreatic Cancer><Ph.D.><PhD><Pilot Projects><Population><Population Heterogeneity><Postbaccalaureate><Postdoc><Postdoctoral Fellow><Process><Prostate CA><Prostate Cancer><Prostate malignancy><Prostatic Cancer><Publications><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Associate><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Specimen><Research Training><Researchers><Resource Sharing><Resources><Scientific Publication><Scientist><Series><South American><Specimen><Students><Tissue Model><Training><Training and Education><Translational Research><Translational Science><US State><USC/Norris Comprehensive Cancer Center><Underrepresented Ethnic Minority><Underrepresented Minority><Underrepresented Students><Underserved Population><United States><Universities><University of Southern California Norris Cancer Center><Use Effectiveness><West Indies Region><Work><anti-cancer research><benchmark><biologic><cancer disparity><cancer health disparity><cancer prevention><cancer research><cancer-related health disparity><career development><community partnership><depository><developmental><disparity in cancer><disparity reduction><diverse populations><drug development><education research><effectiveness using><genetic make-up><genetic makeup><genome resource><genomic data resource><genomic resource><genomic sequencing resource><health disparities science><health disparity community><health disparity group><health disparity populations><health equity><heterogeneous population><improved><improved outcome><innovate><innovation><innovative><innovative technologies><lung cancer><malignancy><meeting><meetings><member><minority communities><minority patient><minority trainee><mitigate disparity><mortality><neoplasm/cancer><new anti-cancer agent><new anticancer agent><new anticancer drug><new antineoplastic><new cancer drug><novel anti-cancer agent><novel anti-cancer drug><novel anticancer agent><novel anticancer drug><novel antineoplastic><novel cancer drug><outreach><pancreatic malignancy><patient population><patients from minority><patients of minority><pilot study><podcast><population diversity><post-doc><post-doctoral><post-doctoral trainee><postbac><postbacc><programs><reduce disparity><reduction in disparity><repository><research associates><social determinants><sociodeterminant><success><tool><translation research><translational cancer research><translational investigation><under served group><under served individual><under served people><under served population><under-representation of minorities><under-represented minority><underrepresentation of minorities><underserved group><underserved individual><underserved people><understudied cancer>