Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Thomas Miller Gallagher · UNIVERSITY OF IOWA · 2020 · $266,291 — PROJECT SUMMARY The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic virus that can cause fatal disease in patients with underlying comorbidities. Further recognition of this respiratory syndrome and prevention strategies will require a small animal infection model as well as an…
JOHN ALTMAN · EMORY UNIVERSITY · 2020 · $333,849 — The NIH Tetramer Core Facility (TCF) distributes high quality reagents for detection of innate T cell and classical CD4 and CD8 T cell populations. This Facility also conducts R&D to produce new reagents and improve existing tetramer technologies. The TCF is producing MHC class I and class II tet…
NIKOLAI PETROVSKY · VAXINE PTY LTD · 2020 · $500,000 — The contractor will formulate a recombinant or nucleic-acid based SARS-CoV2 vaccine with their lead adjuvant, Advax-CpG and test the vaccine in multiple animal species for immunogenicity and efficacy, in preparation for a clinical trial scheduled to start in July 2020. In addition, the contractor wi…
Hana Golding · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · 2020 · $160,000 — The emergence of the Coronavirus (SARS-CoV-2) initiated efforts to rapidly develop effective medical countermeasures including vaccines and therapeutics against this severe disease. However, there is limited knowledge on polyclonal antibody responses generated following vaccination or SARS-CoV-2 inf…
Pamela J Bjorkman · CALIFORNIA INSTITUTE OF TECHNOLOGY · 2020 · $410,750 — Summary The rapid mutation rate of HIV-1 results in many thousands of viral strains, thus thwarting current vaccine efforts. Although HIV-1 infection can be controlled by anti-retroviral therapy (ART), the virus rebounds within weeks of ART cessation because complete elimination of HIV-1 is prevente…
Nour Al-muhtasib · YALE UNIVERSITY · 2020 · $65,310 — The overall goal of this proposal is to investigate the role of endocannabinoid (ECB) signaling in regulating distinct cortical inhibitory synapses. Physiological brain development and function are dependent on a fine-tuned balance of synaptic excitation and inhibition. As such, dysregulation of inh…
Bryce C Chackerian · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $483,855 — Project Summary / Abstract This proposal describes the framework of an R01 grant by Dr. Daniel Lingwood, an Assistant Professor at Harvard Medical School and faculty member of the Ragon Institute of MGH, MIT and Harvard, and Dr. Bryce Chackerian, an Associate Professor in the Department of Molecular…
DWAYNE W GODWIN · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $438,824 — PROJECT SUMMARY Alcohol withdrawal (WD) produces a range of dangerous clinical symptoms, including intense seizures. Hyperexcitability underlying seizures is produced by an array of intrinsic membrane properties that are disrupted by ethanol (EtOH). Prior work has demonstrated that chronic EtOH expo…
LUKAS K TAMM · UNIVERSITY OF VIRGINIA · 2020 · $562,219 — PROJECT SUMMARY Membrane fusion, mediated by viral spike glycoproteins, is a key process in the infection cycle of all enveloped human and animal viruses. The overall goal of this project is to understand the molecular mechanisms of Ebola and human immunodeficiency virus entry by membrane fusion, by…
ANDRE ANTONIO FENTON · NEW YORK UNIVERSITY · 2020 · $343,384 — ABSTRACT Full mutation of the FMR1 gene causes loss of the fragile X mental retardation protein (FMRP) and fragile X syndrome (FXS) characterized by intellectual disability with devastating cognitive consequences and features of autism. Study of Fmr1 knockout (KO) mouse models of the FXS genetic def…
Jixin Zhong · CASE WESTERN RESERVE UNIVERSITY · 2020 · $77,000 — ABSTRACT DPP4 inhibitors (DPP4i) are a novel class of oral anti-diabetic drugs that modulate blood glucose by suppressing DPP4-mediated enzymatic degradation of insulinotropic incretin hormones. However, the non- enzymatic function of DPP4 in diabetes is not well understood. Recent data by us and ot…
Graham Thomas Dempsey · Q-STATE BIOSCIENCES, INC. · 2020 · $771,167 — Project Summary: Synaptic dysfunction has been implicated in many neurological diseases including epilepsy, Alzheimer’s, Parkinson’s, autism spectrum disorder (ASD), schizophrenia, depression, ADHD and Huntington’s. Despite the prevalence and severity of these disorders, the development of new thera…
David Veesler · UNIVERSITY OF WASHINGTON · 2020 · $294,397 — Enveloped viruses use specialized proteins present at the virus surface to translocate their genetic material across the host cell membrane during infection. For coronaviruses, homotrimers of the spike glycoprotein promote host cell attachment and fusion of the viral and host membranes. Although cor…
Jason Scott McLellan · UNIVERSITY OF TEXAS AT AUSTIN · 2020 · $613,032 — Coronaviruses have the largest genomes among known RNA viruses and are phylogenetically divided into four genera. Some betacoronaviruses, such as HKU1, circulate annually in humans and cause mild yet prevalent respiratory disease whereas others, such as SARS-CoV and the recently emerged MERS-CoV, ha…
Bradley Joel Undem · JOHNS HOPKINS UNIVERSITY · 2020 · $528,619 — Asthma, COPD, and chronic cough, as with other visceral inflammatory diseases, are characterized by an over-excited sensory nervous system. When airway sensory nerves are dysregulated by inflammation it can lead to excessive coughing, dyspnea, changes in breathing pattern, and reflex bronchospasm an…
Mikhail G Kolonin · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2020 · $368,900 — White adipose tissue (WAT) is the main lipid reservoir that becomes dysfunctional in obesity. It is important to understand how breached lipid homeostasis leads to metabolic disease. Efficient long chain fatty acid (FA) and cholesterol trafficking depends on a transmembrane transporter protein CD36.…
MARCUS AARON HORWITZ · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $549,664 — Project Summary/Abstract Francisella tularensis is a bacterium that causes tularemia, a disease which, when in its pneumonic form, can be fatal even with appropriate treatment. Due to its low infectious dose, ease of spread by aerosol, and high virulence, F. tularensis is classified as a Tier 1 Sele…
Dennis R. Burton · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $816,869 — Coronaviruses (CoVs) are enveloped, positive-sense, single-stranded RNA viruses and are divided into Alphaand Beta-coronaviruses. CoVs infect mammals and birds and typically result in lower and/or upper respiratory tract disease. The spectrum of illness in humans caused by CoVs range from common co…
DAVID E CLEMENTS · HAWAII BIOTECH, INC. · 2020 · $389,739 — 7. Project Summary/Abstract Coronaviruses have been identified in several avian hosts, as well as in various mammals, including camels, bats, palm civets, mice, dogs, and cats. Among the coronaviruses that are pathogenic to humans, most are associated with mild clinical symptoms. However, In the la…
Kevin Esvelt · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2020 · $399,346 — PROJECT SUMMARY The rapid spread of the highly-pathogenic, novel SARS-coronavirus 2 (SARS-CoV-2) has caused a global health emergency. Thus, there is a desperate need for effective antiviral therapeutics to counteract this virus. The SARS-CoV-2 virus enters cells using the ACE2 receptor1 which binds…