Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Marco E Zamora · DREXEL UNIVERSITY · 2020 · $45,520 — Proposal Summary/Abstract Acute respiratory distress syndrome (ARDS) is an acute inflammation of the lungs. It represents 10% of all intensive care unit (ICU) admissions in the United States. Despite decades of research and numerous large clinical trials, there are few treatments for ARDS. This lack…
Thomas William Geisbert · UNIVERSITY OF TEXAS MED BR GALVESTON · 2020 · $714,651 — PROJECT SUMMARY - Research Project 3 Members of the filovirus genera Ebolavirus and Marburgvirus are HHS Tier 1 Category A priority pathogens that cause severe and often fatal hemorrhagic fever (HF) in humans and nonhuman primates (NHPs). There are presently no approved therapeutics for ebolavirus o…
DONALD R GERECKE · RBHS-SCHOOL OF PUBLIC HEALTH · 2020 · $846,767 — Research Project 1. Vesicant-induced Skin Injury Key personnel: Donald Gerecke, Ph.D., Associate Professor, Rutgers University School of Pharmacy Jeffrey D. Laskin, Ph.D., Professor, Rutgers University School of Public Health Project Summary/Abstract Sulfur mustard (bis-2-chloroethyl sulfide, SM) an…
Bruce Shapiro · DIVISION OF BASIC SCIENCES - NCI · 2020 · $1,074,314 — Recently we developed a new type of RNA nanostructure that forms a truncated tetrahedron in collaboration with Luc Jaeger, UC Santa Barbara. The structure was built from our hexameric ring where 4 sides of the tetrahedral structure each contain the hexmeric ring, but each ring contains 3 H-shaped cr…
Xiang Zhang · UNIVERSITY OF LOUISVILLE · 2020 · $459,749 — Abstract: The primary function of Omics Core is to provide members of the ULARC with the expertise, resources and facilities needed for metabolomic, proteomic and bioinformatic analyses of biological samples collected to study liver injury, nutrition, gut:liver interactions, and liver:environment…
Fekadu Kassie · UNIVERSITY OF MINNESOTA · 2020 · $352,275 — PROJECT SUMMARY Lung cancer is the leading cause of cancer-related death in the United States. About 90% of lung cancer cases are associated with genetic/epigenetic changes induced by tobacco smoke (TS). Although all types of lung cells could be affected by TS, the effect on stem cells is particular…
CYRUS R SAFINYA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · 2020 · $295,627 — Project Summary/Abstract The current level of research activity involving gene therapy with either synthetic vectors (carriers) or engineered viruses is unprecedented. Liposomes are the most widely studied nonviral carriers worldwide for nucleic acid (NA) and drug delivery applications. Cationic lip…
MICHAEL P CZECH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $582,900 — Abstract The overarching long term goal of our laboratory is to understand and exploit how adipose tissues exert powerful control over whole body glucose tolerance and insulin sensitivity. Small amounts of mouse brown (BAT) or human “Beige” adipocytes transplanted into recipient mice can improve glu…
GEORGE K. GITTES · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $374,150 — PROJECT SUMMARY AND RELEVANCE An ideal solution to the treatment or cure of diabetes mellitus would be the formation of new functioning β-cells from the patient’s own tissues, thereby avoiding the need for transplant immunosuppression. Abundant recent data has suggested that α-cells are a likely sou…
Steven Michael Romanelli · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $36,743 — PROJECT SUMMARY The prevalence of obesity has reached pandemic levels with nearly 2 billion people worldwide considered overweight and one-third of that obese. Obesity is associated with an increased risk for type II diabetes, heart disease, and certain types of cancer which severely debilitates qua…
THOMAS Elliott VAN DYKE · ADA FORSYTH INSTITUTE, INC. · 2020 · $463,125 — Project Summary Uncontrolled inflammation is a major impediment to tissue engineering, regeneration and reconstruction of both diseased and injured tissues resulting in further tissue injury, tissue scarring and fibrosis. Stem cell activity is disrupted by persistent signals promoting inflammation, …
Emre H. Brookes · UNIVERSITY OF MONTANA · 2020 · $293,074 — Project Summary/Abstract We propose to continue development and support for the UltraScan-III (US3) software suite and develop new code and methods to address challenging biomedical research questions that can be solved with the latest instruments available for analytical ultracentrifugation and at …
Admire Dube · STELLENBOSCH UNIVERSITY · 2020 · $345,569 — SUMMARY Tuberculosis remains a major global public health threat. Although relatively effective drug regimens are available, treatment failure remains a major roadblock to tuberculosis control. This is in part due to a high incidence of drug-resistant Mycobacterium tuberculosis (Mtb) strains, as wel…
Ta Yuan CHANG · DARTMOUTH COLLEGE · 2020 · $408,373 — ABSTRACT of the administrative supplement proposal for the parent grant “Alleviating lysosomal lipid defects in ADRD by blocking cholesterol storage” The long-term goal of this laboratory is to produce cholesterol metabolism-based therapeutics to treat AD and ADRDs. Vascular dementia (VaD), an ADRD,…
James Dahlman · GEORGIA INSTITUTE OF TECHNOLOGY · 2020 · $748,942 — Summary. Hemoglobinopathies such as β-thalassemia and sickle cell disease are genetic disorders caused by mutations in the HBB gene that codes for the β-globin component of hemoglobin. Currently, the only gene therapy available for these prevalent hereditary diseases is based on transplantation of g…
Weiping Qin · BRONX VETERANS MEDICAL RESEARCH FDN · 2020 · $359,365 — Spinal cord injury (SCI) is a serious medical problem that causes loss of sensory, motor and autonomic function due to the damage of central nerve cells. There are no fully restorative therapies for SCI so far, but there is one FDA approved agent methylprednisolone (MP) that is being used clinically…
Marco Brotto · UNIVERSITY OF SOUTH FLORIDA · 2020 · $409,106 — Project Summary Diabetes is a leading cause of death in the US and worldwide with deleterious consequences to the musculoskeletal system. Regardless of glycemic control, diabetes in skeletal muscle manifests with altered metabolism leading to progressive skeletal muscle loss, functional decline, fas…
Maria Lambros · DORICPHARMA LLC · 2020 · $299,559 — PROJECT SUMMARY/ABSTRACT Pancreatic cancer continues to be a devastating disease with less than 10% 5-year survival. Pancreatic cancer is aggressive and there are no good tools for early detection. By the time of diagnosis, the tumor is often surgically unresectable. At this stage, patients are ofte…
Xiaowei Dong · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · 2020 · $361,504 — Project Summary/Abstract Bioavailability enhancement technologies for insoluble drugs represent incremental progress, but no breakthrough oral drug technologies have been identified in the past three decades. Lipid-based drug delivery systems (LBDDS) are considered as a well-established, very import…
Forrest M Kievit · PROTRANSIT NANOTHERAPY, LLC · 2020 · $259,938 — ABSTRACT Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide and comes with a significant economic burden associated with emergency room visits and hospitalizations. Oxidative stress- mediated secondary injury post-TBI is a considerable risk factor for mortali…