Pandemic-era NIH grants (FY2019-2024) covering coronavirus, gain-of-function research, mRNA vaccines, biosafety, and related funding flows. Metadata + abstracts from NIH RePORTER.
Get an AI answer drawn only from the NIH Pandemic-Era Grants documents indexed here — every claim cited back to the filing or proceeding it came from. It will tell you plainly when the record doesn't cover your question, rather than guessing.
Jay Reddy · UNIVERSITY OF NEBRASKA LINCOLN · 2020 · $183,198 — PROJECT SUMMARY/ABSTRACT An estimated 33% of American adults (85.6 million) have some form of cardiovascular disease, with a projected incidence of 43.9% by 2030. Despite heart disease's status as the leading cause of death in humans, there remains a significant gap in our knowledge of its pathogene…
William Olaf Hancock · PENNSYLVANIA STATE UNIVERSITY, THE · 2020 · $318,780 — PROJECT SUMMARY Intracellular cargo transport along microtubules is driven by kinesin and dynein motors that work antagonistically to precisely target cargo to specific cellular locations. Although the mechanisms underlying bidirectional transport have received considerable attention, a number of v…
Kerry S Campbell · THOMAS JEFFERSON UNIVERSITY · 2020 · $528,500 — Project Summary NK cells are capable of killing virus-infected and cancer cells and, therefore, play an important role in innate host defense. Unlike cytotoxic T lymphocytes (CTL), whose cytolytic activity is induced by productive TCR engagement with cognate pMHC ligands, activation of NK cells is r…
WILLIAM M ATKINS · UNIVERSITY OF WASHINGTON · 2020 · $299,338 — Project Summary P-glycoprotein (P-gp) is an ATP-dependent efflux transporter that plays a critical role in drug and xenobiotic distribution, drug-drug interactions, and drug-nutrient interactions. Efforts to modulate P-gp activity to control cellular drug resistance or to modulate the action of exis…
YUQING Eugene CHEN · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $706,887 — ABSTRACT Reverse cholesterol transport (RCT) is an important protective mechanism against atherosclerosis, in which plasma high-density lipoprotein cholesterol (HDL-c) interacts with macrophages in arterial wall and shuttles excess of cholesterol back to the liver. In macrophages, the cholesterol ef…
WILLIAM E. CARSON · OHIO STATE UNIVERSITY · 2020 · $506,986 — PROJECT SUMMARY RNA nanotechnology has progressed rapidly during the past several years. This nanotechnology includes the integration of multiple functional modules into one nanoparticle, of which the scaffolds, ligands, therapeutics, and regulators can be composed mainly or exclusively of RNA. We …
STACY W BLAIN · CONCARLO HOLDINGS, LLC · 2020 · $320,217 — Project Summary/Abstract The goal of this SBIR is to develop a novel drug, IpY, to improve advanced ER/PR+, Her2- breast cancer outcomes. Almost 250,000 US women will be diagnosed this year, and over 40,000 will die, suggesting that despite advances in treatments, breast cancer remains a significant…
ROBERT J LINHARDT · RENSSELAER POLYTECHNIC INSTITUTE · 2020 · $343,946 — Summary Title: Biacore T200 Surface Plasmon Resonance Spectroscopy Surface plasmon resonance (SPR) spectroscopy is a powerful instrument to measure biomolecular interactions in real-time and a label free environment. SPR has been applied to characterize the binding events with samples ranging from p…
Dana Ashley Hill · CHILDREN'S RESEARCH INSTITUTE · 2020 · $407,577 — DESCRIPTION (provided by applicant): Studies of inherited cancer syndromes have provided unique opportunities to uncover and explain important cellular pathways with broad relevance to both sporadic cancers and human development. This proposal studies the cancer predisposition syndrome original…
Aleksandra Elzbieta Sikora · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · 2020 · $252,429 — ABSTRACT Neisseria gonorrhoeae (Ng) is a human-specific pathogen and the etiological agent of gonorrhea, a sexually transmitted infection with a significant global health burden of ~78 million new cases annually. While often asymptomatic, untreated gonorrhea can lead to pelvic inflammatory disease, …
Hui-Kuan Lin · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $34,569 — The major goals of the newly formed Signaling and Biotechnology (SBT) Program are to understand the mechanisms underlying cancer pathogenesis and resistance to therapy and to use this knowledge to develop new technologies leading to more effective strategies for improved detection and treatment of c…
GABOR J TIGYI · UNIVERSITY OF MARYLAND BALTIMORE · 2020 · $317,625 — The US population at large, and particularly military personnel and first responders, are at risk of radiation exposure due to the explosion of a nuclear device, a nuclear reactor accident, and the threat of radiation terrorism. There is no radiation medical countermeasure (RCM) drug approved by th…
Haifa Shen · METHODIST HOSPITAL RESEARCH INSTITUTE · 2020 · $464,910 — The tumor vasculature is generally considered as leaky, and thus allows accumulation of big molecules and particles within a certain size range to penetrate and retain. Consequently, many cancer drugs have been packaged into simple nanoparticles or composite drug particles in order to improve accumu…
Marco Pravetoni · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2020 · $1,553,762 — Project Summary Opioid use disorders (OUD) are a national public health emergency with more than 115 fatal overdoses occurring each day in the USA. Annually, the economic burden of OUD is over US$78 billion. Several medications are available for treating OUD, but their access is limited and efficacy…
Mark Andrew Borden · UNIVERSITY OF COLORADO · 2020 · $352,275 — The development of new pharmaceuticals for the treatment of brain cancer and neurological disease has outpaced our ability to deliver them safely, largely due to the blood-brain barrier (BBB). Bypassing the BBB to access the brain parenchyma is often highly invasive, involving surgery to remove part…
Jae K Lee · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2020 · $481,767 — PROJECT SUMMARY/ABSTRACT After spinal cord injury (SCI), the injury site is filled with cellular debris, especially myelin debris that creates a very unique lipid-dense environment. Macrophages are the predominant phagocyte that are responsible for debris-clearance, but this process is not only inef…
Gaurav Sahay · OREGON STATE UNIVERSITY · 2020 · $238,145 — ABSTRACT Gene therapy strategies including augmentation, editing or knockdown, can lead to restoration of vision for patients suffering from inherited retinal degenerations (IRDs). Viral and non-viral vectors efficiently deliver genes through the subretinal route of administration, but this requires…
Andre Elias Nel · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $553,064 — The use of nano-enabled chemotherapy to trigger an immune response to pancreatic ductal adenocarcinoma (PDAC) introduces a novel approach for overcoming robust barriers to immunotherapy, including poor immunogenicity, low neoantigen burden, stromal interference (“T-cell exclusion”), overexpression o…
Efstathios Karathanasis · CASE WESTERN RESERVE UNIVERSITY · 2020 · $591,007 — PROJECT SUMMARY First-line chemotherapy is the standard of care for patients with triple-negative breast cancer (TNBC). While short-term response is achievable, most patients succumb to recurrence due to metastasis. Micrometastasis encompasses a small population of dormant disseminated tumor cells (…
Johannes Morstein · NEW YORK UNIVERSITY · 2020 · $32,407 — Project Summary Significant progress in human cancer therapy in the last decade has been driven by conceptionally new approaches to targeting cancer, including cancer immunotherapy, cancer nanotherapy, or new types of biologics and small molecules. Both my dissertation and postdoc research will be f…